nach oben

European Child & Adolescent Psychiatry

Erschienen in:

01.02.2016 | Original Contribution

Chronotherapeutic treatments for depression in youth

verfasst von: Stephanie Gest, Martin Holtmann, Sarah Bogen, Carina Schulz, Benjamin Pniewski, Tanja Legenbauer

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 2/2016

Einloggen, um Zugang zu erhalten

Abstract

Chronotherapeutics such as wake therapy and bright light therapy are well-established methods in treating adults with depressive disorders and are additionally beneficent for sleep regulation. Few studies concerning chronotherapeutics in juvenile depression exist, though the established treatments are insufficient and sleep disorders often co-occur. In this study, we investigate the impact of two types of chronotherapeutics on depressive symptoms and sleep behavior in a juvenile setting. Juvenile inpatients (n = 62) with moderate to severe depressive symptoms took part in either a combined setting consisting of one night wake therapy followed by 2 weeks bright light therapy or in a setting of bright light therapy alone. Depressive symptoms, general psychopathology, clinical impression and sleep behavior were measured before (T1), directly after (T2) and 2 weeks after intervention (T3). Depressive symptoms decreased while sleep quality increased in both groups. The bright light therapy alone group showed further improvement at T3 in regards to depressive symptoms. Correlation analyses indicated significant negative correlations between sleep quality and awaking after restorative sleep with the depressive symptoms. However, only awaking after restorative sleep had a predictive impact on treatment outcome. The present study provides first evidence for a positive impact of chronotherapeutic interventions on treatment outcome in depressed juvenile inpatients. Bright light therapy seems to stabilize and further enhance reduction of depressive symptoms during follow-up, whereas one night wake therapy does not have an additional long-lasting impact on depressive symptoms and sleep parameters.

Nur mit Berechtigung zugänglich

Dewald JF, Meijer AM, Oort FJ, Kerkhof GA, Bögels SM (2010) The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: a meta-analytic review. Sleep Med Rev 14(3):179–189CrossRefPubMed

Brand S, Kirov R (2011) Sleep and its importance in adolescence and in common adolescent somatic and psychiatric conditions. Int J Gen Med 4:425–442PubMedCentralCrossRefPubMed

Gangwisch JE, Babiss LA, Malaspina D, Turner JB, Zammit GK et al (2010) Earlier parental set bedtimes as a protective factor against depression and suicidal ideation. Sleep J Sleep Sleep Disord Res 33(1):97–106

Gregory AM, Sadeh A (2012) Sleep, emotional and behavioral difficulties in children and adolescents. Sleep Med Rev 16(2):129–136CrossRefPubMed

Ivanenko A, Barnes M, Crabtree V, Gozal D (2004) Psychatric symptoms in children with insomnia referred to a pediatric sleep medicine centre. Sleep Med 5(3):253–259CrossRefPubMed

Vandeputte M, de Weerd A (2003) Sleep disorders and depressive feelings: a global survey with the Beck depression scale. Sleep Med 4(4):343–345CrossRefPubMed

Riemann D, Voderholzer U (2003) Primary insomnia: a risk factor to develop depression? J Affect Disord 76(1–3):255–259CrossRefPubMed

Ivanenko A, Johnson K (2008) Sleep disturbances in children with psychiatric disorders. Semin Pediatr Neurol 15(2):70–78CrossRefPubMed

Sunderajan P, Gaynes BN, Wisniewski SR, Miyahara S, Fava M et al (2010) Insomnia in patients with depression: a STAR*D report. CNS Spetrum 15:394–404

10.

O’Brien EM, Chelminski I, Young D, Dalrymple K, Hrabosky J, Zimmerman M (2011) Severe insomnia is associated with more severe presentation and greater functional deficits in depression. J Psychiatr Res 45(8):1101–1105CrossRefPubMed

11.

Kaufman J, Martin A, King RA, Charney D (2001) Are child-, adolescent-, and adult-onset depression one and the same disorder? Biol Psychiatry 49(12):980–1001CrossRefPubMed

12.

Lewinsohn PM, Pettit JW, Joiner TE, Seeley JR (2003) The symptomatic expression of major depressive disorder in adolescents and young adults. J Abnorm Psychol 112(2):244–252CrossRefPubMed

13.

Emslie GJ (2012) The psychopharmacology of adolescent depression. J Child Adolesc Psychopharmacol 22(1):2–4CrossRefPubMed

14.

Costello EJ, Erkanli A, Angold A (2006) Is there an epidemic of child or adolescent depression? J Child Psychol Psychiatry 47(12):1263–1271

15.

Angold A, Costello EJ, Worthman CM (1998) Puberty and depression: the roles of age, pubertal status and pubertal timing. Psychol Med 28(1):51–61CrossRefPubMed

16.

Emslie GJ, Rush AJ, Weinberg WA, Kowatch RA, Hughes CW et al (1997) A double-blind, randomized, placebo- controlled trial of fluoxetine in children and adolescents with depression. Arch Gen Psychiatry 54(11):1031–1047CrossRefPubMed

17.

Kennard BD, Silva S, Vitiello B, Kratochvil C, Simons A et al (2006) Remission and residual symptoms after short-term treatment in the treatment of adolescents with depression study (TADS). J Am Acad Child Adolescent Psychiatry 45(12):1404–1411CrossRef

18.

Kennard BD, Silva SG, Tonev E, Hughes JL, Vitiello B et al (2009) Remission and recovery in the treatment for adolescents with depression study (TADS): acute and long-term outcomes. J Am Acad Child Adolesc Psychiatry 48(2):186–195PubMedCentralCrossRefPubMed

19.

Curry J, Silva S, Rohde P, Ginsburg G, Kratochvil C et al (2011) Recovery and recurrence following treatment for adolescent major depression. Arch Gen Psychiatry 68(3):263–270PubMedCentralCrossRefPubMed

20.

Birmaher B, Brent D, Bernet W, Bukstein O, Walter H et al (2007) Practice parameter for the assessment and treatment of children and adolescents with depressive disorders. J Am Acad Child Adolesc Psychiatry 46(11):1503–1526CrossRefPubMed

21.

Measelle JR, Stice E, Hogansen JM (2006) Developmental trajectories of co-occurring depressive, eating, antisocial, and substance abuse problems in female adolescents. J Abnorm Psychol 115(3):524–538PubMedCentralCrossRefPubMed

22.

Measelle JR, Stice E, Springer DW (2006) A prospective test of the negative affect model of substance abuse: moderating effects of social support. Psychol Addict Behav 20(3):225–233PubMedCentralCrossRefPubMed

23.

Wirz-Justice A, Benedetti F, Terman M (2013) Chronotherapeutics for affective disorders: a clinician’s manual for light and wake therapy 2nd edn. Karger

24.

Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418(6901):935–941CrossRefPubMed

25.

Maywood ES, O’Neill JS, Reddy AB, Chesham JE, Prosser HM et al (2007) Genetic and molecular analysis of the central and peripheral circadian clockwork of mice. Cold Spring Habor Symp Quant Biol 72:85–94CrossRef

26.

Lewy AJ (2007) Melatonin and human chronobiology. Cold Spring Habor Symp Quant Biol 72:623–636CrossRef

27.

Wirz-Justice A, Bader A, Frisch U, Stieglitz RD, Alder J et al (2011) A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression. J Clin Psychiatry 72(7):986–993CrossRefPubMed

28.

Golden RN, Gaynes BN, Ekstrom RD, Hamer RM, Jacobsen FM et al (2005) The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence. Am J Psychiatry 162(4):656–662CrossRefPubMed

29.

Moscovici L, Kotler M (2009) A multistage chronobiologic intervention for the treatment of depression: a pilot study. J Affect Disord 116(3):201–207CrossRefPubMed

30.

Loving RT, Kripke DF, Shuchter SR (2002) Bright light augments antidepressant effects of medication and wake therapy. Depress Anxiety 16(1):1–3CrossRefPubMed

31.

Colombo C, Lucca A, Benedetti F, Barbini B, Campori E et al (2000) Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction. Psychiatry Res 95(1):43–53CrossRefPubMed

32.

Neumeister A, Goessler R, Lucht M, Kapitany T et al (1996) Bright light therapy stabilizes the antidepressant effect of partial sleep deprivation. Biol Psychiatry 39(1):16–21CrossRefPubMed

33.

Niederhofer H, Klitzingvon K (2011) Bright light treatment as add-on therapy for depression in 28 adolescents: a randomized trial. Prim Care Companion CNS disord 13(6)

34.

Swedo SE, Allen AJ, Glod CA, Clark CH, Teicher MH et al (1997) A controlled trial of light therapy for the treatment of pediatric seasonal affective disorder. J Am Acad Child Adolesc Psychiatry 36(6):816–821CrossRefPubMed

35.

Saha S, Pariante CM, McArdle TF, Fombonne E (2000) Very early onset seasonal affective disorder: a case study. Eur J Child Adolesc Psychiatry 9(2):135–138CrossRef

36.

Bogen S, Legenbauer T, Bogen T, Gest S, Jensch T et al (2013) Morning light therapy for juvenile depression and severe mood dysregulation: study protocol for a randomized controlled trial. Trials 14(1):178PubMedCentralCrossRefPubMed

37.

Naylor MW, King CA, Lindsay KA, Evans T, Armelagos J et al (1993) Sleep deprivation in depressed adolescents and psychiatric controls. J Am Acad Child Adolesc Psychiatry 32(4):753–759CrossRefPubMed

38.

Hautzinger M, Keller F, Kühner C (2006) BDI-II Beck Depressions Inventar Revision. Pearson, Hallbergmoos

39.

Besier T, Goldbeck L, Keller F (2008) Psychometric properties of the Beck depression inventory-II (BDI-II) among adolescent psychiatric patients. Psychother Psychosom Med Psychol 58:63–68CrossRefPubMed

40.

Kühner C, Bürger C, Keller F, Hautzinger M (2007) Reliability and validity of the revised beck depression inventory (BDI-II). Results from the german samples. Nervenarzt 78:651–656CrossRefPubMed

41.

Goodman R (1997) The strengths and difficulties questionnaire: a research note. J Child Psychol Psychiatry 38:581–586CrossRefPubMed

42.

Holtmann M, Becker A, Banaschewski T, Rothenberger A, Roessner V (2011) Psychometric validity of the strengths and difficulties questionnaire-dysregulation profile. Psychopathology 44:53–59CrossRefPubMed

43.

Guy W (1976) ECDEU Assessment Manual for Psychopharmacology—Revised. Rockville, MD: US Department of Health, Education, and Welfare; Public Health Service, Alcohol, Drug Abuse and Mental Health Administration; NIMH Psychopharmacology Research Branch Division of Extramural Research Programs, 218–222

44.

Guy W (2000) Clinical global impressions (CGI) scale. In: Rush J et al. (eds) Psychiatric measures. APA, Washington, DC

45.

Görtelmeyer R (2011) Manual of the SF-A/R and SF-B/R—sleep questionnaires A and B—revised version. Hogrefe, Goettingen

46.

Kasper S, Wehr TA, Bartko JJ, Gaist PA, Rosenthal NE (1989) Epidemiological findings of seasonal changes in mood and behavior. A telephone survey of Montgomery County, Maryland. Arch Gen Psychiatry 46:823–833CrossRefPubMed

47.

Steinhausen H-C, Gundelfinger R, Winkler Metzke C (2009) Prevalence of self-reported seasonal affective disorders and the validity of the seasonal pattern assessment questionnaire in young adults: findings from a Swiss community study. J Affect Disord 115:347–354CrossRefPubMed

48.

Griefahn B, Künemund C, Bröde P, Mehnert P (2001) Zur Validität der deutschen Übersetzung des Morningness-Eveningness-Questionnaires von Horne und Östberg. Somnologie 5:71–80CrossRef

49.

Pandi-Perumal SR, Smits M, Spence W, Srinivasan V, Cardinali DP et al (2007) Dim light melatonin onset (DLMO): a tool for the analysis of circadian phase in human sleep and chronobiological disorders. Prog Neuro Psychopharmacol Biol Psychitry 31(1):1–11CrossRef

50.

Weiß RH (2006) CFT 20-R mit WS/ZF-R: Grundintelligenztest Skala 2-Revision (CFT 20-R) mit Wortschatztest und Zahlenfolgentest-Revision (WS/ZF-R). Hogrefe, Göttingen

51.

Kripke DF, Mullaney DJ, Klauber MR, Risch SC, Gillin JC (1992) Controlled trial of bright light for nonseasonal major depressive disorders. Biol Psychiatry 31(2):119–134CrossRefPubMed

52.

Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175–191CrossRefPubMed

53.

Riemann D, Vollmann J, Hohagen F, Lohner H, König A et al (1995) Behandlung von Depressionen mit Schlafentzug und Schlafphasenvorverlagerung. Fortschritte der Neurologie Psychiatrie 63(7):270–276CrossRefPubMed

54.

Babson KA, Trainor CD, Feldner MT, Blumenthal H (2010) A test of the effects of acute sleep deprivation on general and specific self-reported anxiety and depressive symptoms: an experimental extension. J Behav Ther Exp Psychiatry 41(3):297–303PubMedCentralCrossRefPubMed

55.

Goel N, Terman M, Terman JS, Macchi MM, Stewart JW (2005) Controlled trial of bright light and negative air ions for chronic depression. Psychol Med 35(7):945–955CrossRefPubMed

56.

Roenneberg T, Kuehnle T, Juda M, Kantermann T, Allebrandt K et al (2007) Epidemiology of the human circadian clock. Sleep Med Rev 11(6):429–438CrossRefPubMed

57.

Papatheodorou G, Kutcher S (1995) The effect of adjunctive light therapy on ameliorating breakthrough depressive symptoms in adolescent-onset bipolar disorder. J Psychiatry Neurosci 20(3):226–232PubMedCentralPubMed

58.

Benedetti F, Colombo C, Pontiggia A, Bernaconi A, Florita M et al (2003) Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial. J Clin Psychiatry 64(6):648–653CrossRefPubMed

59.

Martiny K, Lunde M, Undén M, Dam H, Bech P (2005) Adjunctive bright light in non-seasonal major depression: results from clinician-rated depression scales. Acta Psychiatr Scand 112(2):117–125CrossRefPubMed

60.

Echizenya M, Suda H, Takeshima M, Inomata Y, Shimizu T (2013) Total sleep deprivation followed by sleep phase advance and bright light therapy in drug-resistant mood disorders. J Affect Disord 144(1–2):28–33CrossRefPubMed

61.

Bortz J (2005) Statistik: Für Human- und Sozialwissenschaftler, 6th edn. Springer-Verlag, Berlin

Titel: Chronotherapeutic treatments for depression in youth
verfasst von: Stephanie Gest
Martin Holtmann
Sarah Bogen
Carina Schulz
Benjamin Pniewski
Tanja Legenbauer
Publikationsdatum: 01.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Child & Adolescent Psychiatry / Ausgabe 2/2016
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-015-0720-6

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

23.04.2024 Depression antepartal oder postpartal Nachrichten

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 DGIM 2024 Kongressbericht

Die Kombination aus Medikamenten und Psychotherapie gilt als effektivster Ansatz bei Depressionen. Das ist bei betagten Menschen nicht anders, trotz Besonderheiten.

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

22.04.2024 DGIM 2024 Nachrichten

Um Menschen nach der Flucht aus einem Krisengebiet bestmöglich medizinisch betreuen zu können, ist es gut zu wissen, welche Erkrankungen im jeweiligen Herkunftsland häufig sind. Dabei hilft eine Internetseite der CDC (Centers for Disease Control and Prevention).

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2016

Development of national capabilities in low and middle income countries for research in child mental health

Erratum to: Differential susceptibility to maternal expressed emotion in children with ADHD and their siblings? Investigating plasticity genes, prosocial and antisocial behaviour

Stigma in youth with Tourette’s syndrome: a systematic review and synthesis

Provision of evidence-based intervention is not part of the DSM-5 diagnostic criteria for Specific Learning Disorder