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European Journal of Trauma and Emergency Surgery

23.04.2024 | Original Article

Comparison of analgesic efficacy of ibuprofen and dexketoprofen in pain management of long bone fractures: a prospective, randomized, double-blind study

verfasst von: Safa Dönmez, Alp Sener, Nurullah Ishak Isık, İlker Akbas, Kadir Yenal, Bekir Kaya

Erschienen in: European Journal of Trauma and Emergency Surgery

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Abstract

Introduction

Long bone fractures (LBF) often cause severe pain, impacting patients’ quality of life. This prospective, randomized, double-blind study aimed to compare the analgesic efficacy of dexketoprofen (Dex) and ibuprofen (Ibu) in LBF patients in the emergency department.

Methods

Conducted between August 10, 2023, and January 17, 2024, the study included 100 eligible patients randomized into Dex and Ibu groups. Visual analog scale (VAS) scores were measured at baseline and at 30, 60, and 120 min. DeltaVAS (ΔVAS) values and ΔVAS percentages (ΔVAS%) were calculated. Primary endpoints were ΔVAS scores (ΔVAS 30-60-120) and ΔVAS% for comparative analysis.

Results

Statistical analysis showed no significant difference in ΔVAS30 (p = 0.359). However, ΔVAS60 exhibited a significant difference (p = 0.027), as did ΔVAS120 (p = < 0.001). ΔVAS%30 showed no significance (p = 0.224), but ΔVAS%60 and ΔVAS%120 were clinically and statistically significant (p = 0.017 and p = < 0.001, respectively).

Conclusion

Ibuprofen 800 mg demonstrated superior analgesic efficacy at 60 and 120 min compared to Dex in long bone fractures. These findings suggest ibuprofen’s potential as an effective pain management option in emergency departments.

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Titel: Comparison of analgesic efficacy of ibuprofen and dexketoprofen in pain management of long bone fractures: a prospective, randomized, double-blind study
verfasst von: Safa Dönmez
Alp Sener
Nurullah Ishak Isık
İlker Akbas
Kadir Yenal
Bekir Kaya
Publikationsdatum: 23.04.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Trauma and Emergency Surgery
Print ISSN: 1863-9933
Elektronische ISSN: 1863-9941
DOI: https://doi.org/10.1007/s00068-024-02515-w

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