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20.01.2022 | Leading Article

Complement Mediators in Development to Treat Age-Related Macular Degeneration

verfasst von: Marcella Nebbioso, Federica Franzone, Alessandro Lambiase, Samanta Taurone, Marco Artico, Magda Gharbiya, Antonio Greco, Antonella Polimeni

Erschienen in: Drugs & Aging | Ausgabe 2/2022

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Abstract

Over recent years, great attention has been paid to the role of the complement system in the pathogenesis of age-related macular degeneration (AMD). In particular, several studies have highlighted a link between AMD development and complement dysregulation, which can probably be explained as a complement cascade hyperactivation resulting from the presence of a series of risk factors such as aging; smoking; obesity; alcohol consumption; exposure to pesticides, industrial chemicals, or pollution; and other causes of oxidative stress. This hypothesis has been mainly supported by the presence of complement mediators as constituents of drusen, representing one of the earliest and most characteristic signs of retinal damage in AMD. Additionally, activated complement mediators and some complement regulators, such as vitronectin, have been found not only in the drusen and adjacent retinal areas but also in the peripheral blood of patients with AMD. Therefore, we aim to provide a review of recently studied complement factors to highlight their role in the pathogenesis of AMD and to evaluate new potential therapeutic strategies.

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Titel: Complement Mediators in Development to Treat Age-Related Macular Degeneration
verfasst von: Marcella Nebbioso
Federica Franzone
Alessandro Lambiase
Samanta Taurone
Marco Artico
Magda Gharbiya
Antonio Greco
Antonella Polimeni
Publikationsdatum: 20.01.2022
Verlag: Springer International Publishing
Erschienen in: Drugs & Aging / Ausgabe 2/2022
Print ISSN: 1170-229X
Elektronische ISSN: 1179-1969
DOI: https://doi.org/10.1007/s40266-021-00914-x

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