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Erschienen in: European Journal of Nutrition 4/2015

01.06.2015 | Original Contribution

Consumption of berries, fruits and vegetables and mortality among 10,000 Norwegian men followed for four decades

verfasst von: Anette Hjartåker, Markus Dines Knudsen, Steinar Tretli, Elisabete Weiderpass

Erschienen in: European Journal of Nutrition | Ausgabe 4/2015

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Abstract

Purpose

The association between vegetable and fruit consumption and risk of cancer and cardiovascular disease (CVD) has been investigated by several studies, whereas fewer studies have examined consumption of vegetables and fruits in relation to all-cause mortality. Studies on berries, a rich source of antioxidants, are rare. The purpose of the current study was to examine the association between intake of vegetables, fruits and berries (together and separately) and the risk of all-cause mortality and cause-specific mortality due to cancer and CVD and subtypes of these, in a cohort with very long follow-up.

Methods

We used data from a population-based prospective Norwegian cohort study of 10,000 men followed from 1968 through 2008. Information on vegetable, fruit and berry consumption was available from a food frequency questionnaire. Association between these and all-cause mortality, cause-specific mortality due to cancers and CVDs were investigated using Cox proportional hazard regression models.

Results

Men who in total consumed vegetables, fruit and berries more than 27 times per month had an 8–10 % reduced risk of all-cause mortality compared with men with a lower consumption. They also had a 20 % reduced risk of stroke mortality. Consumption of fruit was inversely related to overall cancer mortality, with hazard rate ratios of 0.94, 0.84 and 0.79 in the second, third and firth quartile, respectively, compared with the first quartile.

Conclusion

Increased consumption of vegetables, fruits and berries was associated with a delayed risk of all-cause mortality and of mortality due to cancer and stroke.
Literatur
1.
Zurück zum Zitat Mathers C, Stevens G, Mascarenhas M (2009) Global health risks: mortality and burden of disease attributable to selected major risks. World Health Organization, Geneva Mathers C, Stevens G, Mascarenhas M (2009) Global health risks: mortality and burden of disease attributable to selected major risks. World Health Organization, Geneva
2.
Zurück zum Zitat Crowe FL, Roddam AW, Key TJ, Appleby PN, Overvad K, Jakobsen MU, Tjonneland A, Hansen L, Boeing H, Weikert C, Linseisen J, Kaaks R, Trichopoulou A, Misirli G, Lagiou P, Sacerdote C, Pala V, Palli D, Tumino R, Panico S, Bueno-de-Mesquita HB, Boer J, van Gils CH, Beulens JW, Barricarte A, Rodriguez L, Larranaga N, Sanchez MJ, Tormo MJ, Buckland G, Lund E, Hedblad B, Melander O, Jansson JH, Wennberg P, Wareham NJ, Slimani N, Romieu I, Jenab M, Danesh J, Gallo V, Norat T, Riboli E (2011) Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. Eur Heart J 32(10):1235–1243. doi:10.1093/eurheartj/ehq465 CrossRef Crowe FL, Roddam AW, Key TJ, Appleby PN, Overvad K, Jakobsen MU, Tjonneland A, Hansen L, Boeing H, Weikert C, Linseisen J, Kaaks R, Trichopoulou A, Misirli G, Lagiou P, Sacerdote C, Pala V, Palli D, Tumino R, Panico S, Bueno-de-Mesquita HB, Boer J, van Gils CH, Beulens JW, Barricarte A, Rodriguez L, Larranaga N, Sanchez MJ, Tormo MJ, Buckland G, Lund E, Hedblad B, Melander O, Jansson JH, Wennberg P, Wareham NJ, Slimani N, Romieu I, Jenab M, Danesh J, Gallo V, Norat T, Riboli E (2011) Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. Eur Heart J 32(10):1235–1243. doi:10.​1093/​eurheartj/​ehq465 CrossRef
3.
Zurück zum Zitat World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AICR, Washington World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AICR, Washington
4.
Zurück zum Zitat Norat T, Aune D, Chan D, Romaguera D (2014) Fruits and vegetables: updating the epidemiologic evidence for the WCRF/AICR lifestyle recommendations for cancer prevention. Cancer Treat Res 159:35–50. doi:10.1007/978-3-642-38007-5_3 CrossRef Norat T, Aune D, Chan D, Romaguera D (2014) Fruits and vegetables: updating the epidemiologic evidence for the WCRF/AICR lifestyle recommendations for cancer prevention. Cancer Treat Res 159:35–50. doi:10.​1007/​978-3-642-38007-5_​3 CrossRef
5.
Zurück zum Zitat Lock K, Pomerleau J, Causer L, Altmann DR, McKee M (2005) The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet. Bull World Health Organ 83(2):100–108. doi:10.1590/S0042-96862005000200010 Lock K, Pomerleau J, Causer L, Altmann DR, McKee M (2005) The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet. Bull World Health Organ 83(2):100–108. doi:10.​1590/​S0042-9686200500020001​0
6.
7.
Zurück zum Zitat Black WC, Haggstrom DA, Welch HG (2002) All-cause mortality in randomized trials of cancer screening. J Natl Cancer Inst 94(3):167–173CrossRef Black WC, Haggstrom DA, Welch HG (2002) All-cause mortality in randomized trials of cancer screening. J Natl Cancer Inst 94(3):167–173CrossRef
8.
9.
Zurück zum Zitat Leenders M, Sluijs I, Ros MM, Boshuizen HC, Siersema PD, Ferrari P, Weikert C, Tjonneland A, Olsen A, Boutron-Ruault MC, Clavel-Chapelon F, Nailler L, Teucher B, Li K, Boeing H, Bergmann MM, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Pala V, Panico S, Tumino R, Sacerdote C, Peeters PH, van Gils CH, Lund E, Engeset D, Redondo ML, Agudo A, Sanchez MJ, Navarro C, Ardanaz E, Sonestedt E, Ericson U, Nilsson LM, Khaw KT, Wareham NJ, Key TJ, Crowe FL, Romieu I, Gunter MJ, Gallo V, Overvad K, Riboli E, Bueno-de-Mesquita HB (2013) Fruit and vegetable consumption and mortality: European prospective investigation into cancer and nutrition. Am J Epidemiol 178(4):590–602. doi:10.1093/aje/kwt006 CrossRef Leenders M, Sluijs I, Ros MM, Boshuizen HC, Siersema PD, Ferrari P, Weikert C, Tjonneland A, Olsen A, Boutron-Ruault MC, Clavel-Chapelon F, Nailler L, Teucher B, Li K, Boeing H, Bergmann MM, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Pala V, Panico S, Tumino R, Sacerdote C, Peeters PH, van Gils CH, Lund E, Engeset D, Redondo ML, Agudo A, Sanchez MJ, Navarro C, Ardanaz E, Sonestedt E, Ericson U, Nilsson LM, Khaw KT, Wareham NJ, Key TJ, Crowe FL, Romieu I, Gunter MJ, Gallo V, Overvad K, Riboli E, Bueno-de-Mesquita HB (2013) Fruit and vegetable consumption and mortality: European prospective investigation into cancer and nutrition. Am J Epidemiol 178(4):590–602. doi:10.​1093/​aje/​kwt006 CrossRef
11.
Zurück zum Zitat Bradbury KE, Appleby PN, Key TJ (2014) Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr 100(Supplement 1):394S–398S. doi:10.3945/ajcn.113.071357 CrossRef Bradbury KE, Appleby PN, Key TJ (2014) Fruit, vegetable, and fiber intake in relation to cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr 100(Supplement 1):394S–398S. doi:10.​3945/​ajcn.​113.​071357 CrossRef
12.
Zurück zum Zitat Hartley L, Igbinedion E, Holmes J, Flowers N, Thorogood M, Clarke A, Stranges S, Hooper L, Rees K (2013) Increased consumption of fruit and vegetables for the primary prevention of cardiovascular diseases. Cochrane Database Syst Rev 6:CD009874. doi:10.1002/14651858.CD009874.pub2 Hartley L, Igbinedion E, Holmes J, Flowers N, Thorogood M, Clarke A, Stranges S, Hooper L, Rees K (2013) Increased consumption of fruit and vegetables for the primary prevention of cardiovascular diseases. Cochrane Database Syst Rev 6:CD009874. doi:10.​1002/​14651858.​CD009874.​pub2
13.
Zurück zum Zitat Carlsen MH, Halvorsen BL, Holte K, Bohn SK, Dragland S, Sampson L, Willey C, Senoo H, Umezono Y, Sanada C, Barikmo I, Berhe N, Willett WC, Phillips KM, Jacobs DR Jr, Blomhoff R (2010) The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J 9:3. doi:10.1186/1475-2891-9-3 CrossRef Carlsen MH, Halvorsen BL, Holte K, Bohn SK, Dragland S, Sampson L, Willey C, Senoo H, Umezono Y, Sanada C, Barikmo I, Berhe N, Willett WC, Phillips KM, Jacobs DR Jr, Blomhoff R (2010) The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J 9:3. doi:10.​1186/​1475-2891-9-3 CrossRef
14.
Zurück zum Zitat Akesson A, Andersen LF, Kristjansdottir AG, Roos E, Trolle E, Voutilainen E, Wirfalt E (2013) Health effects associated with foods characteristic of the Nordic diet: a systematic literature review. Food Nutr Res 57. doi:10.3402/fnr.v57i0.22790 Akesson A, Andersen LF, Kristjansdottir AG, Roos E, Trolle E, Voutilainen E, Wirfalt E (2013) Health effects associated with foods characteristic of the Nordic diet: a systematic literature review. Food Nutr Res 57. doi:10.​3402/​fnr.​v57i0.​22790
16.
Zurück zum Zitat Halvorsen BL, Holte K, Myhrstad MC, Barikmo I, Hvattum E, Remberg SF, Wold AB, Haffner K, Baugerod H, Andersen LF, Moskaug O, Jacobs DR Jr, Blomhoff R (2002) A systematic screening of total antioxidants in dietary plants. J Nutr 132(3):461–471 Halvorsen BL, Holte K, Myhrstad MC, Barikmo I, Hvattum E, Remberg SF, Wold AB, Haffner K, Baugerod H, Andersen LF, Moskaug O, Jacobs DR Jr, Blomhoff R (2002) A systematic screening of total antioxidants in dietary plants. J Nutr 132(3):461–471
17.
Zurück zum Zitat Bjelke E (1971) Variation in height and weight in the Norwegian population. Br J Prev Soc Med 25(4):192–202 Bjelke E (1971) Variation in height and weight in the Norwegian population. Br J Prev Soc Med 25(4):192–202
18.
Zurück zum Zitat Magnus K, Hougen A, Andersen A, Pedersen E (1970) A study of disease in migrants and their siblings: development of sibling rosters. J Chronic Dis 23(5):405–410CrossRef Magnus K, Hougen A, Andersen A, Pedersen E (1970) A study of disease in migrants and their siblings: development of sibling rosters. J Chronic Dis 23(5):405–410CrossRef
19.
Zurück zum Zitat Bjelke E (1974) Epidemiologic studies of cancer of the stomach, colon, and rectum; with special emphasis on the role of diet. Scand J Gastroenterol Suppl 31:1–235 Bjelke E (1974) Epidemiologic studies of cancer of the stomach, colon, and rectum; with special emphasis on the role of diet. Scand J Gastroenterol Suppl 31:1–235
20.
Zurück zum Zitat Statistisk Sentralbyrå (1998) Annexes. In: Dødsårsaker 1995. Statistisk Sentralbyrå, Oslo/Kongsvinger, Norway, pp 1–226 Statistisk Sentralbyrå (1998) Annexes. In: Dødsårsaker 1995. Statistisk Sentralbyrå, Oslo/Kongsvinger, Norway, pp 1–226
23.
Zurück zum Zitat Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB (2013) Heart disease and stroke statistics–2013 update: a report from the American Heart Association. Circulation 127(1):e6–e245. doi:10.1161/CIR.0b013e31828124ad CrossRef Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Magid D, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Nichol G, Paynter NP, Schreiner PJ, Sorlie PD, Stein J, Turan TN, Virani SS, Wong ND, Woo D, Turner MB (2013) Heart disease and stroke statistics–2013 update: a report from the American Heart Association. Circulation 127(1):e6–e245. doi:10.​1161/​CIR.​0b013e31828124ad​ CrossRef
24.
Zurück zum Zitat Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB (2014) Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose–response meta-analysis of prospective cohort studies. Circulation 129(6):643–659. doi:10.1161/CIRCULATIONAHA.113.005925 CrossRef Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB (2014) Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose–response meta-analysis of prospective cohort studies. Circulation 129(6):643–659. doi:10.​1161/​CIRCULATIONAHA.​113.​005925 CrossRef
25.
Zurück zum Zitat Boffetta P, Couto E, Wichmann J, Ferrari P, Trichopoulos D, Bueno-de-Mesquita HB, van Duijnhoven FJ, Buchner FL, Key T, Boeing H, Nothlings U, Linseisen J, Gonzalez CA, Overvad K, Nielsen MR, Tjonneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault MC, Morois S, Lagiou P, Naska A, Benetou V, Kaaks R, Rohrmann S, Panico S, Sieri S, Vineis P, Palli D, van Gils CH, Peeters PH, Lund E, Brustad M, Engeset D, Huerta JM, Rodriguez L, Sanchez MJ, Dorronsoro M, Barricarte A, Hallmans G, Johansson I, Manjer J, Sonestedt E, Allen NE, Bingham S, Khaw KT, Slimani N, Jenab M, Mouw T, Norat T, Riboli E, Trichopoulou A (2010) Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 102(8):529–537. doi:10.1093/jnci/djq072 Boffetta P, Couto E, Wichmann J, Ferrari P, Trichopoulos D, Bueno-de-Mesquita HB, van Duijnhoven FJ, Buchner FL, Key T, Boeing H, Nothlings U, Linseisen J, Gonzalez CA, Overvad K, Nielsen MR, Tjonneland A, Olsen A, Clavel-Chapelon F, Boutron-Ruault MC, Morois S, Lagiou P, Naska A, Benetou V, Kaaks R, Rohrmann S, Panico S, Sieri S, Vineis P, Palli D, van Gils CH, Peeters PH, Lund E, Brustad M, Engeset D, Huerta JM, Rodriguez L, Sanchez MJ, Dorronsoro M, Barricarte A, Hallmans G, Johansson I, Manjer J, Sonestedt E, Allen NE, Bingham S, Khaw KT, Slimani N, Jenab M, Mouw T, Norat T, Riboli E, Trichopoulou A (2010) Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 102(8):529–537. doi:10.​1093/​jnci/​djq072
26.
Zurück zum Zitat The Norwegian Directory of Health (2013) Utviklingen i norsk kosthold 2013 The Norwegian Directory of Health (2013) Utviklingen i norsk kosthold 2013
27.
Zurück zum Zitat Trygg K, Lund-Larsen K (1980) Kostholdsundersøkelser hos menn: del av Røke-lipidprosjektet, Oslo-undersøkelsen. Landsforeningen for kosthold og helse, Oslo Trygg K, Lund-Larsen K (1980) Kostholdsundersøkelser hos menn: del av Røke-lipidprosjektet, Oslo-undersøkelsen. Landsforeningen for kosthold og helse, Oslo
28.
Zurück zum Zitat Trygg K (1977) Kostholdsundersøkelser blant skogsarbeidere i Hurdal. Landsforeningen for kosthold og helse Trygg K (1977) Kostholdsundersøkelser blant skogsarbeidere i Hurdal. Landsforeningen for kosthold og helse
29.
Zurück zum Zitat Oyebode O, Gordon-Dseagu V, Walker A, Mindell JS (2014) Fruit and vegetable consumption and all-cause, cancer and CVD mortality: analysis of Health Survey for England data. J Epidemiol Commun Health. doi:10.1136/jech-2013-203500 Oyebode O, Gordon-Dseagu V, Walker A, Mindell JS (2014) Fruit and vegetable consumption and all-cause, cancer and CVD mortality: analysis of Health Survey for England data. J Epidemiol Commun Health. doi:10.​1136/​jech-2013-203500
31.
Zurück zum Zitat Boeing H, Bechthold A, Bub A, Ellinger S, Haller D, Kroke A, Leschik-Bonnet E, Muller MJ, Oberritter H, Schulze M, Stehle P, Watzl B (2012) Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr 51(6):637–663. doi:10.1007/s00394-012-0380-y CrossRef Boeing H, Bechthold A, Bub A, Ellinger S, Haller D, Kroke A, Leschik-Bonnet E, Muller MJ, Oberritter H, Schulze M, Stehle P, Watzl B (2012) Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr 51(6):637–663. doi:10.​1007/​s00394-012-0380-y CrossRef
32.
Zurück zum Zitat Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren WM, Albus C, Benlian P, Boysen G, Cifkova R, Deaton C, Ebrahim S, Fisher M, Germano G, Hobbs R, Hoes A, Karadeniz S, Mezzani A, Prescott E, Ryden L, Scherer M, Syvanne M, Op Reimer WJ, Vrints C, Wood D, Zamorano JL, Zannad F (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Int J Behav Med 19(4):403–488. doi:10.1007/s12529-012-9242-5 CrossRef Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren WM, Albus C, Benlian P, Boysen G, Cifkova R, Deaton C, Ebrahim S, Fisher M, Germano G, Hobbs R, Hoes A, Karadeniz S, Mezzani A, Prescott E, Ryden L, Scherer M, Syvanne M, Op Reimer WJ, Vrints C, Wood D, Zamorano JL, Zannad F (2012) European guidelines on cardiovascular disease prevention in clinical practice (version 2012): the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Int J Behav Med 19(4):403–488. doi:10.​1007/​s12529-012-9242-5 CrossRef
35.
Zurück zum Zitat Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr (2007) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr 85(3):895–909 Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, Jacobs DR Jr (2007) Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr 85(3):895–909
Metadaten
Titel
Consumption of berries, fruits and vegetables and mortality among 10,000 Norwegian men followed for four decades
verfasst von
Anette Hjartåker
Markus Dines Knudsen
Steinar Tretli
Elisabete Weiderpass
Publikationsdatum
01.06.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 4/2015
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-014-0741-9

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