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01.12.2014 | Original Article

Definition of K^trans and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study

verfasst von: T. Engelhorn, MD, M. A. Schwarz, MSc, A. Hess, PhD, L. Budinsky, PhD, P. Pitann, I. Eyüpoglu, PhD, A. Doerfler, PhD

Erschienen in: Clinical Neuroradiology | Ausgabe 4/2014

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Abstract

Purpose

To define K^trans and fractional anisotropy (FA) thresholds in correlation to histology for improved magnetic resonance imaging (MRI) tumor assessment in an animal model of brain glioma.

Methods

Twelve rats underwent 4.7 T MRI at day 10 after tumor implantation. Anatomical scans (T₂, T₁ at 8 min after double dose contrast application) as well as dynamic contrast-enhanced (DCE) imaging with calculation of K^trans and diffusion tensor imaging (DTI) with calculation of FA were performed. T₂- and T₁-derived tumor volumes were calculated and thresholds for K^trans and FA were defined for best MRI tumor assessment correlated to histology.

Results

Tumor volumes were 159 ± 14 mm³ (histology), 126 ± 26 mm³ (T₁ with contrast, r = 0.76), and 153 ± 12 mm³ (T₂, r = 0.84), respectively. K^trans- and FA-derived tumor volumes were 160 ± 16 mm³ (for K^trans ³ 0.04 min⁻¹, r = 0.94), and 159 ± 14 mm³ (for FA £ 0.14, r = 0.96), respectively.

Conclusions

DCE-MRI and DTI with calculation of K^trans and FA maps allow very precise brain glioma assessment comparable to histology if established thresholds for the given tumor model are used.

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Titel: Definition of Ktrans and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study
verfasst von: T. Engelhorn, MD
M. A. Schwarz, MSc
A. Hess, PhD
L. Budinsky, PhD
P. Pitann
I. Eyüpoglu, PhD
A. Doerfler, PhD
Publikationsdatum: 01.12.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Neuroradiology / Ausgabe 4/2014
Print ISSN: 1869-1439
Elektronische ISSN: 1869-1447
DOI: https://doi.org/10.1007/s00062-013-0257-3

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Definition of K^trans and FA Thresholds for Better Assessment of Experimental Glioma Using High-field MRI: A Feasibility Study

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Purpose

Methods

Results

Conclusions

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