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01.07.2015 | Original Article

DEGRO guidelines for the radiotherapy of non-malignant disorders

Part III: Hyperproliferative disorders

verfasst von: M. Heinrich Seegenschmiedt, M.D., Oliver Micke, M.D., Marcus Niewald, M.D., PD Dr. med. Ralph Mücke, M.D., Hans Theodor Eich, M.D., Jan Kriz, M.D., Reinhard Heyd, M.D., The German Cooperative Group on Radiotherapy of Benign Diseases (GCG-BD)

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 7/2015

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Abstract

Background and purpose

Radiation therapy (RT) is an established and effective treatment modality in the management of a large variety of hyperproliferative disorders and benign neoplasms. Objective of this article is to summarize the updated DEGRO consensus S2e guideline recommendations.

Materials and methods

This report comprises an overview of the relevant aspects of the updated guidelines with regard to treatment decision, dose prescription, and RT technique for a selected group of disorders including Morbus Dupuytren (MD)/Morbus Ledderhose (ML), keloids, Peyronie’s disease (induratio penis plastica, IPP), desmoid tumors, pigmented villonodular synovitis (PVNS), symptomatic vertebral hemangiomas (sVH), and Gorham–Stout syndrome (GSS). On the basis of results in the literature, we attempted to classify the level of evidence (LoE) and the grade of recommendation (GR) according to the Oxford criteria.

Results

There is comprehensive evidence in the literature that RT is a reasonable and effective treatment modality for the treatment of all the above-mentioned disorders. The LoE varies from 2c to 4, and GR varies from A to C.

Conclusions

The use of RT can be recommended for the interdisciplinary management of most of the reported disorders. It can be used in the primary treatment approach and as an effective adjunct to other treatment modalities or in some indications as a valuable alternative treatment option. We hope that the updated DEGRO S2e consensus guideline recommendations are a helpful tool for radiation oncologists in the clinical decision-making process.

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Titel: DEGRO guidelines for the radiotherapy of non-malignant disorders
Part III: Hyperproliferative disorders
verfasst von: M. Heinrich Seegenschmiedt, M.D.
Oliver Micke, M.D.
Marcus Niewald, M.D.
PD Dr. med. Ralph Mücke, M.D.
Hans Theodor Eich, M.D.
Jan Kriz, M.D.
Reinhard Heyd, M.D.
The German Cooperative Group on Radiotherapy of Benign Diseases (GCG-BD)
Publikationsdatum: 01.07.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Strahlentherapie und Onkologie / Ausgabe 7/2015
Print ISSN: 0179-7158
Elektronische ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-015-0818-2

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DEGRO guidelines for the radiotherapy of non-malignant disorders

Part III: Hyperproliferative disorders