Background
Results
Effect of neonatal chemical sympathectomy on neuropathic pain-related behavior after SNI
SNI and sympathetic sprouting in the DRG
Discussion
Neuropathic pain model
|
sympX timing (related to nerve injury)
|
Type of sympX
|
Mechanical allodynia
|
Mechanical hyperalgesia
|
Heat hyper-sensitivity
|
Cold hyper-sensitivity
|
---|---|---|---|---|---|---|
CCI
| 5 d prior | Chemical GU |
↔
(a)
|
↘↘↘
(a)
|
↘↘↘
(a)
| |
Intra-operative | Surgical |
↔/↗
(b,1)
|
↘↘
(b)
|
↘↘↘
(b)
| ||
1 w after | Surgical |
↘
(k)
|
↘
(k)
| |||
10 d after | Chemical GU |
↘
(a)
|
↘↘
(a)
|
↘↘↘
(a)
| ||
PSL
| 7 and 4 d prior | Chemical GU |
↔
(c)
|
↘
(c)
| ||
Intra-operative | Chemical GU |
↗
(c,2)
|
↗
(c,2)
| |||
1 w after | Surgical |
↘
(k)
|
↘
(k)
| |||
7 m after | Chemical GU |
↘↘↘
(c)
|
↘↘↘
(c)
| |||
SNL L5 or SNL L5/L6 | 1 w prior | Surgical |
↘↘↘
(d)
, ↔
(h)
|
↘↘↘
(d)
| ||
Intra-operative | Surgical |
↔
(g)
|
↘
(f)
| |||
Intra-operative | Chemical GU/PM |
↔
(g)
| ||||
4 d after | Surgical |
↘↘↘
(f)
|
↘↘
(d,e)
|
↘
(k)
, ↘↘↘
(e)
| ||
1 w after | Surgical |
↘↘↘
(d,k,e,i)
, ↔
(h)
, ↘↘
(j)
|
↘↘
(d)
| |||
2 w after | Chemical GU/PM |
↘↘
(d)
| ||||
3 w after | Surgical |
↘↘↘
(d)
, ↔
(h)
| ||||
5 w after | Surgical |
↘↘↘
(d)
|