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01.09.2014 | Original Contribution

Determinants of the transition from a cardiometabolic normal to abnormal overweight/obese phenotype in a Spanish population

verfasst von: Helmut Schröder, Rafel Ramos, José M. Baena-Díez, Michelle A. Mendez, Dolors Juvinyà Canal, Montserrat Fíto, Joan Sala, Roberto Elosua

Erschienen in: European Journal of Nutrition | Ausgabe 6/2014

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Abstract

Purpose

There is limited prospective evidence at population scale of the impacts of lifestyle and surrogate measures of general and abdominal adiposity on the transition of a metabolically healthy (absence of a metabolic disorder) overweight/obese (MHOO) phenotype to a metabolically abnormal overweight/obese (MAOO) phenotype. Therefore, we determined the relationship between 10-year body mass index (BMI), waist circumferences (WC), waist to height ratio (WHtR), and lifestyle changes and the transition of the MHOO phenotype.

Methods

We conducted a prospective population-based study of 3,052 male and female Spaniards aged 25–74 years who were followed from 2000 through 2009. Diet and leisure-time physical activity were recorded on validated questionnaires. Weight, height, WC, blood lipids, glycemia, and blood pressure were measured. All variables were obtained at baseline (BL) and follow-up (FL). Participants with a BMI ≥ 25 kg/m² and free from hypercholesterolemia, hypertriglyceridemia, diabetes, hypertension, and low HDL and high LDL cholesterol levels were characterized as the MHOO phenotype. A composite healthy lifestyle index (HLI) was constructed by including temporary changes in 3 lifestyle variables (diet, leisure-time physical activity, and smoking).

Results

Initially, 20.8 % of subjects had the MHOO phenotype; 49.2 % of these shifted to MAOO phenotype. In multivariate analysis, changes in BMI, WC, WHtR were positively associated (p = 0.004, p = 0.018, and p = 0.016, respectively) with this transition. One unit increase in the HLI was associated with a 33 % lower risk (p = 0.025) to the MAOO phenotype transition after adjusting for age, sex, educational level, and baseline energy intake, BMI, WC, and WHtR.

Conclusions

The presence of metabolic disorders in the MHOO phenotype is predicted by an increase in anthropometric surrogate measures of general and abdominal adiposity. In contrast, a healthy lifestyle protects against a transition to the MAOO phenotype.

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Titel: Determinants of the transition from a cardiometabolic normal to abnormal overweight/obese phenotype in a Spanish population
verfasst von: Helmut Schröder
Rafel Ramos
José M. Baena-Díez
Michelle A. Mendez
Dolors Juvinyà Canal
Montserrat Fíto
Joan Sala
Roberto Elosua
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 6/2014
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-013-0635-2

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Determinants of the transition from a cardiometabolic normal to abnormal overweight/obese phenotype in a Spanish population