Skip to main content
Erschienen in: Diabetologia 7/2011

01.07.2011 | Commentary

Diabetes and cognitive performance: a story that is still unfolding

verfasst von: A. M. Jacobson

Erschienen in: Diabetologia | Ausgabe 7/2011

Einloggen, um Zugang zu erhalten

Excerpt

One question voiced by patients and clinicians is whether diabetes could lead to brain damage and cognitive dysfunction. Careful systematic studies are extremely important to ascertain the nature and extent of these central nervous system complications. …
Literatur
1.
Zurück zum Zitat Cukierman-Yaffe T, Gerstein HC, Williamson JD et al (2009) Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) Trial. Diabetes Care 32:221–226PubMedCrossRef Cukierman-Yaffe T, Gerstein HC, Williamson JD et al (2009) Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes (ACCORD-MIND) Trial. Diabetes Care 32:221–226PubMedCrossRef
2.
Zurück zum Zitat Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens PC (2006) Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5:64–74PubMedCrossRef Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens PC (2006) Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5:64–74PubMedCrossRef
3.
Zurück zum Zitat The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group (2007) Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med 356:1842–1852CrossRef The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group (2007) Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med 356:1842–1852CrossRef
4.
Zurück zum Zitat Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP Jr, Selby JV (2009) Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301:1565–1572PubMedCrossRef Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP Jr, Selby JV (2009) Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301:1565–1572PubMedCrossRef
5.
Zurück zum Zitat Zammitt NN, Frier BM (2005) Hypoglycemia in type 2 diabetes: pathophysiology, frequency, and effects of different treatment modalities. Diabetes Care 28:2948–2961PubMedCrossRef Zammitt NN, Frier BM (2005) Hypoglycemia in type 2 diabetes: pathophysiology, frequency, and effects of different treatment modalities. Diabetes Care 28:2948–2961PubMedCrossRef
6.
Zurück zum Zitat Jacobson AM, Ryan CM, Cleary PA et al (2011) Biomedical risk factors for decreased cognitive functioning in type 1 diabetes: an 18 year follow-up of the Diabetes Control and Complications Trial (DCCT) cohort. Diabetologia 54:245–255PubMedCrossRef Jacobson AM, Ryan CM, Cleary PA et al (2011) Biomedical risk factors for decreased cognitive functioning in type 1 diabetes: an 18 year follow-up of the Diabetes Control and Complications Trial (DCCT) cohort. Diabetologia 54:245–255PubMedCrossRef
7.
Zurück zum Zitat Ding J, Strachan MWJ, Reynolds RM et al (2010) Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes 59:2883–2889PubMedCrossRef Ding J, Strachan MWJ, Reynolds RM et al (2010) Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes 59:2883–2889PubMedCrossRef
8.
Zurück zum Zitat Sanz C, Andrieu S, Sinclair A, Hanaire H, REAL.FR Study Group (2009) Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease. Neurology 73:1359–1366PubMedCrossRef Sanz C, Andrieu S, Sinclair A, Hanaire H, REAL.FR Study Group (2009) Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease. Neurology 73:1359–1366PubMedCrossRef
9.
Zurück zum Zitat Christman AL, Matsushita K, Gottesman RF et al. (2011) Glycated haemoglobin and cognitive decline: the Atherosclerosis Risk in Communities (ARIC) Study. Diabetologia. doi:10.1007/s00125-011-2095-7 Christman AL, Matsushita K, Gottesman RF et al. (2011) Glycated haemoglobin and cognitive decline: the Atherosclerosis Risk in Communities (ARIC) Study. Diabetologia. doi:10.​1007/​s00125-011-2095-7
10.
Zurück zum Zitat Rizzo M, Marfella R, Barbieri M et al (2010) Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients. Diabetes Care 33:2169–2174PubMedCrossRef Rizzo M, Marfella R, Barbieri M et al (2010) Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients. Diabetes Care 33:2169–2174PubMedCrossRef
11.
Zurück zum Zitat Young SE, Mainous AG 3rd, Carnemolla M (2006) Hyperinsulinemia and cognitive decline in a middle-aged cohort. Diabetes Care 29:2688–2693PubMedCrossRef Young SE, Mainous AG 3rd, Carnemolla M (2006) Hyperinsulinemia and cognitive decline in a middle-aged cohort. Diabetes Care 29:2688–2693PubMedCrossRef
12.
Zurück zum Zitat Knopman D, Boland LL, Mosley T et al (2001) Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology 9(56):42–48 Knopman D, Boland LL, Mosley T et al (2001) Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology 9(56):42–48
13.
Zurück zum Zitat Wong TY, Klein R, Sharrett AR et al (2002) Atheroslerosis risk in communities study. Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 288:67–74PubMedCrossRef Wong TY, Klein R, Sharrett AR et al (2002) Atheroslerosis risk in communities study. Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 288:67–74PubMedCrossRef
14.
Zurück zum Zitat Knopman DS, Mosley TH, Catellier DJ, Coker LH, Atherosclerosis Risk in Communities Study Brain MRI Study (2009) Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI Study. Alzheimers Dement 5:207–214PubMedCrossRef Knopman DS, Mosley TH, Catellier DJ, Coker LH, Atherosclerosis Risk in Communities Study Brain MRI Study (2009) Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI Study. Alzheimers Dement 5:207–214PubMedCrossRef
15.
Zurück zum Zitat Pavlik VN, de Moraes SA, Szklo M, Knopman DS, Mosley TH Jr, Hyman DJ (2003) Relation between cognitive function and mortality in middle-aged adults: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 157:327–334PubMedCrossRef Pavlik VN, de Moraes SA, Szklo M, Knopman DS, Mosley TH Jr, Hyman DJ (2003) Relation between cognitive function and mortality in middle-aged adults: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 157:327–334PubMedCrossRef
16.
Zurück zum Zitat Wong TY, Mosley TH Jr, Klein R, Klein BE, Sharrett AR, Couper DJ, Hubbard LD (2003) Atherosclerosis Risk in Communities Study. Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people. Neurology 61:806–811PubMed Wong TY, Mosley TH Jr, Klein R, Klein BE, Sharrett AR, Couper DJ, Hubbard LD (2003) Atherosclerosis Risk in Communities Study. Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people. Neurology 61:806–811PubMed
17.
Zurück zum Zitat Alves de Moraes S, Szklo M, Knopman D, Sato R (2002) The relationship between temporal changes in blood pressure and changes in cognitive function: Atherosclerosis Risk in Communities (ARIC) Study. Prev Med 35:258–263PubMedCrossRef Alves de Moraes S, Szklo M, Knopman D, Sato R (2002) The relationship between temporal changes in blood pressure and changes in cognitive function: Atherosclerosis Risk in Communities (ARIC) Study. Prev Med 35:258–263PubMedCrossRef
18.
Zurück zum Zitat Alonso A, Mosley TH Jr, Gottesman RF, Catellier D, Sharrett AR, Coresh J (2009) Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) Study. J Neurol Neurosurg Psychiatry 80:1194–1201PubMedCrossRef Alonso A, Mosley TH Jr, Gottesman RF, Catellier D, Sharrett AR, Coresh J (2009) Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) Study. J Neurol Neurosurg Psychiatry 80:1194–1201PubMedCrossRef
19.
Zurück zum Zitat Lyoo IK, Yoon S, Musen G et al (2009) Altered cerebral glutamate–glutamine–γ-aminobutyric acid levels and low cognitive performance and depressive symptoms in type 1 diabetes mellitus. Arch Gen Psychiatry 66:879–887CrossRef Lyoo IK, Yoon S, Musen G et al (2009) Altered cerebral glutamate–glutamine–γ-aminobutyric acid levels and low cognitive performance and depressive symptoms in type 1 diabetes mellitus. Arch Gen Psychiatry 66:879–887CrossRef
20.
Zurück zum Zitat Suzuki R, Lee K, Jing E et al (2010) Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab 12:567–579PubMedCrossRef Suzuki R, Lee K, Jing E et al (2010) Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab 12:567–579PubMedCrossRef
21.
Zurück zum Zitat Musen G, Lyoo IK, Sparks CR et al (2006) Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry. Diabetes 55:326–333PubMedCrossRef Musen G, Lyoo IK, Sparks CR et al (2006) Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry. Diabetes 55:326–333PubMedCrossRef
22.
Zurück zum Zitat Kodl CT, Franc DT, Rao JP et al (2008) Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function. Diabetes 57:3083–3089PubMedCrossRef Kodl CT, Franc DT, Rao JP et al (2008) Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function. Diabetes 57:3083–3089PubMedCrossRef
Metadaten
Titel
Diabetes and cognitive performance: a story that is still unfolding
verfasst von
A. M. Jacobson
Publikationsdatum
01.07.2011
Verlag
Springer-Verlag
Erschienen in
Diabetologia / Ausgabe 7/2011
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-011-2154-0

Weitere Artikel der Ausgabe 7/2011

Diabetologia 7/2011 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

17.05.2024 Plötzlicher Herztod Nachrichten

Ein signifikanter Anteil der Fälle von plötzlichem Herztod ist genetisch bedingt. Um ihre Verwandten vor diesem Schicksal zu bewahren, sollten jüngere Personen, die plötzlich unerwartet versterben, ausnahmslos einer Autopsie unterzogen werden.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

17.05.2024 Herzinsuffizienz Nachrichten

Bei adipösen Patienten mit Herzinsuffizienz des HFpEF-Phänotyps ist Semaglutid von symptomatischem Nutzen. Resultiert dieser Benefit allein aus der Gewichtsreduktion oder auch aus spezifischen Effekten auf die Herzinsuffizienz-Pathogenese? Eine neue Analyse gibt Aufschluss.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.