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Erschienen in:
01.05.2015 | Original article
Diastolic dysfunction and contrast-induced nephropathy in patients undergoing coronary angiography
Erschienen in: Herz | Sonderheft 3/2015
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Objectives
It has been demonstrated that decreased left ventricular ejection fraction (LVEF) is associated with an increased risk of contrast-induced nephropathy (CIN). In this study, we aimed to assess whether there is a relationship between left ventricular (LV) diastolic dysfunction and renal function decline after coronary angiography (CAG).
Patients and methods
The study consisted of two groups: group I, patients with normal diastolic function; group II, patients with cardiac symptoms and abnormal diastolic function. Serum creatinine (Crea) and glomerular filtration rates (GFR) were measured before and after 48 h of CAG.
Results
After the procedure, serum Crea values were higher in group II compared with group I (p = 0.051). Postprocedural 48-h GFR values determined by Cockcroft–Gault and Modification of Diet in Renal Disease (MDRD) equations were lower in group II compared with group I (p = 0.016 and p = 0.003, respectively). Delta (Δ) ΔCrea and ΔGFR determined by the Cockcroft–Gault and MDRD equations were statistically higher in group II than in group I (p = 0.005, p = 0.052, p = 0.030). The presence of higher age (p = 0.025), E/E’ lateral ratio (p = 0.030), and left atrial volume index (p = 0.05) were independent predictors of worsening renal function.
Conclusion
The presence of diastolic dysfunction may play a role in determining the risk of CIN in patients with normal LVEF.