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International Journal of Colorectal Disease

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01.02.2010 | Original Article

Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis

verfasst von: Yun Tian, Yi Li, Zhenhua Hu, Daqing Wang, Xiyang Sun, Changshan Ren

Erschienen in: International Journal of Colorectal Disease | Ausgabe 2/2010

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Abstract

Introduction

Since Kurzawski et al. described an association between the 3020insC NOD2 single nucleotide polymorphism and the risk of colorectal cancer(CRC) in 2004, reports published in the past several years have controversial results regarding the relationship between the development of CRC and NOD2 gene polymorphisms. To clarify the potential role of NOD2 P286S, R702W, G908R, and 3020insC polymorphisms in CRC patients, we have undertaken a systematic review and meta-analysis of published articles.

Materials and methods

Studies reporting on NOD2 polymorphisms and CRC were searched in the PubMed, EMBASE, and the Science Citation Index from the inception of each database to May, 2009. The search strategy included the keywords “CRC”, “colon cancer”, “rectal cancer”, “polymorphism”, and “NOD2/CARD15”.

Result

Eight eligible case-control studies about Caucasians from four countries contributed data on 5,888 subjects (cases: 3,524; controls: 2,364). Compared to the wild genotype, the R702W, G908R, and 3020insC polymorphisms were associated with an increased risk of CRC (odds ratio (OR): 1.59, 1.98, 1.44; 95% confidence interval (CI): 1.09–2.32, 1.14–3.44, 1.13–1.84; P = 0.02, 0.01, 0.003). However, P268S polymorphism did not influence CRC risk (OR: 1.27; CI: 0.32–5.00; P = 0.73).

Conclusions

These findings indicate that NOD2 R702W, G908R, and 3020insC polymorphisms contribute to CRC susceptibility in Caucasians. Meta-analysis of these polymorphisms in NOD2 gene will help determine their role in CRC carcinogenesis.

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Titel: Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis
verfasst von: Yun Tian
Yi Li
Zhenhua Hu
Daqing Wang
Xiyang Sun
Changshan Ren
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: International Journal of Colorectal Disease / Ausgabe 2/2010
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-009-0809-9

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Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis

Abstract

Introduction

Materials and methods

Result

Conclusions

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