Erschienen in:
01.08.2013 | Gastrointestinal
Diffusion-weighted and T2-weighted MR imaging for colorectal liver metastases detection in a rat model at 7 T: a comparative study using histological examination as reference
verfasst von:
Mathilde Wagner, Léon Maggiori, Maxime Ronot, Valérie Paradis, Valérie Vilgrain, Yves Panis, Bernard E. Van Beers
Erschienen in:
European Radiology
|
Ausgabe 8/2013
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Abstract
Objectives
To compare diffusion-weighted (DW) and T2-weighted MR imaging in detecting colorectal liver metastases in a rat model, using histological examination as a reference method.
Methods
Eighteen rats had four liver injections of colon cancer cells. MR examinations at 7 T included FSE-T2-weighted imaging and SE-DW MR imaging (b = 0, 20 and 150 s/mm2) and were analysed by two independent readers. Histological examination was performed on 0.4-mm slices. McNemar’s test was used to compare the sensitivities and the Wilcoxon matched pairs test to compare the average number of false-positives per rat.
Results
One hundred and sixty-six liver metastases were identified on histological examination. The sensitivity in detecting liver metastases was significantly higher on DW MR than on T2-weighted images (99/166 (60 %) (reader 1) and 92/166 (55 %) (reader 2) versus 77/166 (46 %), P ≤ 0.001), without an increase in false-positives per rat (P = 0.773/P = 0.850). After stratification according to metastasis diameter, DW MR imaging had a significantly higher sensitivity than T2-weighted imaging only for metastases with a diameter (0.6–1.2 mm) similar to that of the spatial resolution of MR imaging in the current study.
Conclusions
This MR study with histological correlations shows the higher sensitivity of DW relative to T2-weighted imaging at 7 T for detecting liver metastases, especially small ones.
Key Points
• Diffusion weighted (DW) sequences are increasingly used in magnetic resonance imaging (MRI).
• DW has higher sensitivity for liver metastases than T2-weighted imaging at 7 T.
• This increase in sensitivity is especially marked for small liver metastasis detection.
• This higher sensitivity is confirmed in an animal model with histological correlation.
• DW imaging has the potential for earlier diagnosis of small liver metastases.