Background
Patients and methods
Radiosurgery alone N patients (%) | Radiosurgery + WBRT N patients (%) | P -value | |
---|---|---|---|
Radiosurgery dose
| |||
<20 Gy (n = 23) | 10 (33) | 13 (46) | |
≥20 Gy (n = 35) | 20 (67) | 15 (54) | 0.63 |
Age
| |||
≤59 years (n = 34) | 17 (57) | 17 (61) | |
≥60 years (n = 24) | 13 (43) | 11 (39) | 0.94 |
ECOG performance score
| |||
0-1 (n = 40) | 20 (67) | 20 (71) | |
2 (n = 18) | 10 (33) | 8 (29) | 0.93 |
Number of cerebral metastases
| |||
1 (n = 46) | 25 (83) | 21 (75) | |
2-3 (n = 12) | 5 (17) | 7 (25) | 0.84 |
Maximum diameter of all brain metastases
| |||
≤10 mm (n = 28) | 15 (50) | 13 (46) | |
≥11 mm (n = 30) | 15 (50) | 15 (54) | 0.95 |
Site of brain metastases
| |||
Supratentorial (n = 39) | 20 (67) | 19 (68) | |
Infratentorial ± supratentorial (n = 19) | 10 (33) | 9 (32) | 0.98 |
Extra-cranial metastases
| |||
No (n = 24) | 11 (37) | 13 (46) | |
Yes (n = 34) | 19 (63) | 15 (54) | 0.75 |
Time from breast cancer diagnosis to radiotherapy
| |||
≤48 months (n = 30) | 15 (50) | 15 (54) | |
≥49 months (n = 28) | 15 (50) | 13 (46) | 0.95 |
Results
At 6 months (%) | At 12 months (%) | P -value | |
---|---|---|---|
Treatment regimen
| |||
Radiosurgery alone (n = 30) | 86 | 79 | |
Radiosurgery + WBI (n = 28) | 96 | 92 | 0.59 |
Radiosurgery dose
| |||
<20 Gy (n = 23) | 83 | 78 | |
≥20 Gy (n = 35) | 97 | 90 | 0.23 |
Age
| |||
≤59 years (n = 34) | 97 | 91 | |
≥60 years (n = 24) | 83 | 77 | 0.066 |
ECOG performance score
| |||
0-1 (n = 40) | 95 | 87 | |
2 (n = 18) | 82 | 82 | 0.69 |
Number of cerebral metastases
| |||
1 (n = 46) | 91 | 83 | |
2-3 (n = 12) | 92 | 92 | 0.58 |
Maximum diameter of all brain metastases
| |||
≤10 mm (n = 28) | 93 | 89 | |
≥11 mm (n = 30) | 90 | 81 | 0.66 |
Site of brain metastases
| |||
Supratentorial (n = 39) | 92 | 83 | |
Infratentorial ± supratentorial (n = 19) | 89 | 89 | 0.35 |
Extra-cranial metastases
| |||
No (n = 24) | 88 | 79 | |
Yes (n = 34) | 94 | 91 | 0.31 |
Time from breast cancer diagnosis to radiotherapy
| |||
≤48 months (n = 30) | 93 | 86 | |
≥49 months (n = 28) | 89 | 85 | 0.61 |
At 6 months (%) | At 12 months (%) | P -value | |
---|---|---|---|
Treatment regimen
| |||
Radiosurgery alone (n = 30) | 79 | 68 | |
Radiosurgery + WBI (n = 28) | 96 | 89 |
0.040
|
Radiosurgery dose
| |||
<20 Gy (n = 23) | 78 | 74 | |
≥20 Gy (n = 35) | 94 | 81 | 0.72 |
Age
| |||
≤59 years (n = 34) | 91 | 88 | |
≥60 years (n = 24) | 83 | 61 | 0.20 |
ECOG performance score
| |||
0-1 (n = 40) | 90 | 82 | |
2 (n = 18) | 82 | 66 |
0.012
|
Number of cerebral metastases
| |||
1 (n = 46) | 87 | 74 | |
2-3 (n = 12) | 92 | 92 | 0.98 |
Maximum diameter of all brain metastases
| |||
≤10 mm (n = 28) | 89 | 81 | |
≥11 mm (n = 30) | 86 | 74 | 0.21 |
Site of brain metastases
| |||
Supratentorial (n = 39) | 89 | 75 | |
Infratentorial ± supratentorial (n = 19) | 84 | 84 | 0.50 |
Extra-cranial metastases
| |||
No (n = 24) | 92 | 73 | |
Yes (n = 34) | 85 | 82 | 0.89 |
Time from breast cancer diagnosis to radiotherapy
| |||
≤48 months (n = 30) | 90 | 82 | |
≥49 months (n = 28) | 86 | 73 | 0.33 |
At 6 months | At 12 months | P -value | |
---|---|---|---|
Treatment regimen
| |||
Radiosurgery alone (n = 30) | 80 | 63 | |
Radiosurgery + WBI (n = 28) | 93 | 71 | 0.48 |
Radiosurgery dose
| |||
<20 Gy (n = 23) | 83 | 65 | |
≥20 Gy (n = 35) | 89 | 69 | 0.56 |
Age
| |||
≤59 years (n = 34) | 91 | 76 | |
≥60 years (n = 24) | 79 | 54 | 0.054 |
ECOG performance score
| |||
0-1 (n = 40) | 98 | 85 | |
2 (n = 18) | 61 | 28 |
<0.001
|
Number of cerebral metastases
| |||
1 (n = 46) | 83 | 63 | |
2-3 (n = 12) | 100 | 83 | 0.67 |
Maximum diameter of all brain metastases
| |||
≤10 mm (n = 28) | 89 | 79 | |
≥11 mm (n = 30) | 83 | 57 | 0.16 |
Site of brain metastases
| |||
Supratentorial (n = 39) | 85 | 64 | |
Infratentorial ± supratentorial (n = 19) | 89 | 74 | 0.22 |
Extra-cranial metastases
| |||
No (n = 24) | 88 | 75 | |
Yes (n = 34) | 85 | 62 | 0.38 |