Introduction
Materials and methods
Patients
Data collection
Immunohistochemical detection
Follow-up
Statistical analysis
Results
Patients’ characteristics
Variables | Favorable (n = 53) | Unfavorable (n = 78) | Total (n = 131) | X2 or Z | p-value |
---|---|---|---|---|---|
Age, median (P25, P75) | 56 (51.5, 66.5) | 61 (51.0, 70.5) | 1.304* | 0.192 | |
Gender, n (%) | |||||
Female | 15 (28.3) | 22 (28.2) | 37 | 0.000# | 1.000 |
Male | 38 (71.7) | 56 (71.8) | 94 | ||
Nerve invasion (n, %) | |||||
No | 52 (98.1) | 74 (94.9) | 126 | 0.236# | 0.627 |
Yes | 1 (1.9) | 4 (5.1) | 5 | ||
Vascular invasion (n, %) | |||||
No | 51 (96.2) | 70 (89.7) | 121 | 1.074# | 0.300 |
Yes | 2 (3.8) | 8 (10.3) | 10 | ||
Cigarette smoking (n, %) | |||||
No | 22 (41.5) | 31 (39.7) | 53 | 0.041# | 0.858 |
Yes | 31 (58.5) | 47 (60.3) | 78 | ||
Alcohol drinking (n, %) | |||||
No | 26 (54.7) | 25 (44.9) | 59 | 0.581# | 0.478 |
Yes | 27 (50.9) | 45 (57.7) | 72 | ||
Tumor site (n, %) | |||||
Tonsil | 29 (54.7) | 35 (44.9) | 64 | 5.128# | 0.077 |
Tongue base | 23 (43.4) | 33 (42.3) | 56 | ||
Other+ | 1 (1.9) | 10 (12.8) | 11 | ||
Positive margin (n, %) | |||||
No | 14 (26.4) | 26 (33.3) | 40 | 1.202# | 0.570 |
Yes | 1 (1.9) | 3 (3.8) | 4 | ||
No-operation | 38 (71.7) | 49 (62.8) | 87 | ||
Extranodal extension (n, %) | |||||
No | 13 (24.5) | 23 (29.5) | 36 | 0.560# | 0.756 |
Yes | 4 (7.5) | 7 (9.0) | 11 | ||
No-operation | 36 (67.9) | 48 (61.5) | 84 | ||
Muscular/capsule invasion (n, %) | |||||
No | 6 (11.3) | 21 (26.9) | 27 | 4.696# | 0.096 |
Yes | 10 (18.9) | 12 (15.4) | 22 | ||
No-operation | 37 (69.8) | 45 (57.7) | 82 | ||
Stage (n, %) | |||||
I–II | 10 (18.9) | 13 (16.7) | 23 | 0.106# | 0.817 |
III–IV | 43 (81.1) | 65 (83.3) | 108 | ||
T stage (n, %) | |||||
I–II | 27 (50.9) | 38 (48.7) | 65 | 0.063# | 0.806 |
III–IV | 26 (49.1) | 40 (51.3) | 66 | ||
N stage (n, %) | |||||
N0 | 17 (32.1) | 24 (30.8) | 41 | 0.025# | 1.000 |
N+ | 36 (67.9) | 54 (69.2) | 90 | ||
Progression (n, %) | |||||
No | 26 (49.1) | 23 (29.5) | 49 | 5.162# | 0.028 |
Yes | 27 (50.9) | 55 (70.5) | 82 | ||
Death (n, %) | |||||
No | 35 (66.0) | 37 (47.4) | 72 | 4.411# | 0.049 |
Yes | 18 (34.0) | 41 (52.6) | 59 |
Value of an unfavorable dynamic change of the SII as an independent indicator for OPC progression or death
Factors associated with recurrence and their progression or death significance
Variables | DFS | OS | ||||||
---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
Dynamic SII | 1.90 (1.20–3.03) | 0.007* | 1.77 (1.10–2.85) | 0.019* | 2.11 (1.20–3.69) | 0.009* | 2.01 (1.13–3.59) | 0.018* |
Age | 0.99 (0.97–1.01) | 0.349 | 1.01 (0.99–1.03) | 0.400 | ||||
Gender | 1.28 (0.76–2.17) | 0.351 | 0.93 (0.52–1.6) | 0.808 | ||||
Tumor site | ||||||||
Tonsil$ | 0.103 | 0.320 | ||||||
Pharyngolaryngeal fossa | 0.75 (0.10–5.51) | 0.779 | 0.00 (0.00–0.00) | 0.978 | ||||
Soft palate | 1.41 (0.55–3.63) | 0.474 | 1.72 (0.64–4.60) | 0.282 | ||||
Tongue base | 1.88 (1.19–2.98) | 0.007* | 2.06 (1.26–3.37) | 0.004* | 1.80 (1.02–3.18) | 0.043* | 1.99 (1.12–3.55) | 0.019* |
Uvula | 1.93 (0.26–14.21) | 0.518 | 2.83 (0.38–21.18) | 0.312 | ||||
Stage | 2.09 (1.00–4.34) | 0.049* | 1.93 (0.86–4.34) | 0.039* | 1.40 (0.63–3.08) | 0.410 | ||
T stage | 1.62 (1.05–2.51) | 0.031* | 1.13 (0.69–2.51) | 0.113 | 1.45 (0.86–2.43) | 0.163 | ||
N stage | 1.12 (0.69–1.80) | 0.645 | 1.97 (0.57–2.67) | 0.922 | ||||
Positive margin | 1.95 (0.75–2.70) | 0.650 | 1.05 (0.79–1.39) | 0.735 | ||||
Extranodal extension | 1.91 (0.37–2.51) | 0.435 | 1.00 (0.75–1.33) | 0.990 | ||||
Muscular or capsule invasion | 1.03 (0.92–1.20) | 0.556 | 1.08 (0.71–1.35) | 0.894 | ||||
Nerve invasion | 1.25 (0.30–5.13) | 0.760 | 1.27 (0.11–5.59) | 0.794 | ||||
Vascular invasion | 1.84 (0.79–4.28) | 0.157 | 4.07 (1.69–9.79) | 0.002* | 4.22 (1.69–10.49) | 0.002* | ||
Cigarette smoking | 1.42 (0.90–2.24) | 0.136 | 1.19 (0.69–2.05) | 0.524 | ||||
Alcohol drinking | 1.58 (1.01–2.49) | 0.046* | 1.66 (1.03–2.66) | 0.037* | 1.31 (0.77–2.22) | 0.316 |