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Erschienen in: European Journal of Orthopaedic Surgery & Traumatology 3/2008

01.04.2008 | Original Article

Early outcomes after ALIF with cage and plate in discogenic low back pain: a quantitative analysis

verfasst von: S. Champain, V. Fière, A. Mitulescu, P. Schmitt, W. Skalli

Erschienen in: European Journal of Orthopaedic Surgery & Traumatology | Ausgabe 3/2008

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Abstract

Background

Though the anterior lumbar interbody fusion with cages is an interesting option in the treatment of discogenic low back pain, cage-related complications opened the way to alternative options like circumferential fusion or recent ALIF techniques using cages and anterior instrumentation. As the latter are rather recent, the aim of this prospective study was to quantitatively evaluate the early outcomes after ALIF with anterior cage and plate construct.

Methods

Pre- and postoperative data of 41 patients (mean age 42 years) were analyzed from a clinical, socio-professional, quality of life and biomechanical point of view, with a mean follow-up of 1.8 years. Evaluation was based on clinical data, four scores (SF-12, JOA, VAS, patient satisfaction index) and several radiological parameters (describing spine geometry and balance) for an accurate outcome assessment.

Results

In 1 and 2 years follow-up exams, good and excellent outcomes were found in 92% of cases, associated with high levels of quality of life (83%) and satisfaction (95%), but also with a late return to work (40% at 1 year and 76% at 2 years). Outcome was not related to postoperative disc narrowing, observed in 15% of patients. Radiological parameters values highlighted normal spine geometry and balance in 71% of cases and were postoperatively constant in most patients.

Conclusion

From a clinical and functional point of view, the early outcomes after ALIF with cage and plate were in agreement with success ranges in the literature; they were completed by good levels of quality of life and patient’s satisfaction. In addition to subsidence detection, biomechanical analysis offered a detailed insight into the evolution of the treated segment and on its impact on spine’s stability and balance.
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Literatur
1.
Zurück zum Zitat Beutler WJ, Peppelman WC Jr (2003) Anterior lumbar fusion with paired BAK standard and paired BAK Proximity cages: subsidence incidence, subsidence factors, and clinical outcome. Spine J 3:289–293PubMedCrossRef Beutler WJ, Peppelman WC Jr (2003) Anterior lumbar fusion with paired BAK standard and paired BAK Proximity cages: subsidence incidence, subsidence factors, and clinical outcome. Spine J 3:289–293PubMedCrossRef
2.
Zurück zum Zitat Blumenthal SL, Ohnmeiss DD (2003) Intervertebral cages for degenerative spinal diseases. Spine J 3:301–309PubMedCrossRef Blumenthal SL, Ohnmeiss DD (2003) Intervertebral cages for degenerative spinal diseases. Spine J 3:301–309PubMedCrossRef
3.
Zurück zum Zitat Burkus JK, Gornet MF, Dickman CA, Zdeblick TA (2002) Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15:337–349PubMed Burkus JK, Gornet MF, Dickman CA, Zdeblick TA (2002) Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15:337–349PubMed
4.
Zurück zum Zitat Champain S, Benchikh K, Nogier A, Mazel C, Guise JD, Skalli W (2006) Validation of new clinical quantitative analysis software applicable in spine orthopaedic studies. Eur Spine J 15:982–991PubMedCrossRef Champain S, Benchikh K, Nogier A, Mazel C, Guise JD, Skalli W (2006) Validation of new clinical quantitative analysis software applicable in spine orthopaedic studies. Eur Spine J 15:982–991PubMedCrossRef
5.
Zurück zum Zitat Cheung KM, Zhang YG, Lu DS, Luk KD, Leong JC (2003) Reduction of disc space distraction after anterior lumbar interbody fusion with autologous iliac crest graft. Spine 28:1385–1389PubMedCrossRef Cheung KM, Zhang YG, Lu DS, Luk KD, Leong JC (2003) Reduction of disc space distraction after anterior lumbar interbody fusion with autologous iliac crest graft. Spine 28:1385–1389PubMedCrossRef
6.
Zurück zum Zitat Choi JY, Sung KH (2006) Subsidence after anterior lumbar interbody fusion using paired stand-alone rectangular cages. Eur Spine J 15:16–22PubMedCrossRef Choi JY, Sung KH (2006) Subsidence after anterior lumbar interbody fusion using paired stand-alone rectangular cages. Eur Spine J 15:16–22PubMedCrossRef
7.
Zurück zum Zitat Chung SK, Lee SH, Lim SR, Kim DY, Jang JS, Nam KS, Lee HY (2003) Comparative study of laparoscopic L5-S1 fusion versus open mini-ALIF, with a minimum 2-year follow-up. Eur Spine J 12:613–617PubMedCrossRef Chung SK, Lee SH, Lim SR, Kim DY, Jang JS, Nam KS, Lee HY (2003) Comparative study of laparoscopic L5-S1 fusion versus open mini-ALIF, with a minimum 2-year follow-up. Eur Spine J 12:613–617PubMedCrossRef
8.
Zurück zum Zitat Daltroy LH, Cats-Baril WL, Katz JN, Fossel AH, Liang MH (1996) The North American spine society lumbar spine outcome assessment instrument: reliability and validity tests. Spine 21:741–749PubMedCrossRef Daltroy LH, Cats-Baril WL, Katz JN, Fossel AH, Liang MH (1996) The North American spine society lumbar spine outcome assessment instrument: reliability and validity tests. Spine 21:741–749PubMedCrossRef
9.
Zurück zum Zitat Dennis S, Watkins R, Landaker S, Dillin W, Springer D (1989) Comparison of disc space heights after anterior lumbar interbody fusion. Spine 14:876–878PubMedCrossRef Dennis S, Watkins R, Landaker S, Dillin W, Springer D (1989) Comparison of disc space heights after anterior lumbar interbody fusion. Spine 14:876–878PubMedCrossRef
10.
Zurück zum Zitat Dunlop RB, Adams MA, Hutton WC (1984) Disc space narrowing and the lumbar facet joints. J Bone Joint Surg Br 66:706–710PubMed Dunlop RB, Adams MA, Hutton WC (1984) Disc space narrowing and the lumbar facet joints. J Bone Joint Surg Br 66:706–710PubMed
11.
Zurück zum Zitat Evans JH (1985) Biomechanics of lumbar fusion. Clin Orthop Relat Res:38–46 Evans JH (1985) Biomechanics of lumbar fusion. Clin Orthop Relat Res:38–46
12.
Zurück zum Zitat Fiere V, Mulsant P (2003) Retrospective study of 80 cases of anterior lumbar interbody fusion with combined PEEK Cages and an Anterior Specific Plate. In: Proceedings of the 5th international disc cage and prosthesis meeting, Lenzerheide Fiere V, Mulsant P (2003) Retrospective study of 80 cases of anterior lumbar interbody fusion with combined PEEK Cages and an Anterior Specific Plate. In: Proceedings of the 5th international disc cage and prosthesis meeting, Lenzerheide
13.
14.
Zurück zum Zitat Frobin W, Brinckmann P, Biggemann M, Tillotson M, Burton K (1997) Precision measurement of disc height, vertebral height and sagittal plane displacement from lateral radiographic views of the lumbar spine. Clin Biomech (Bristol, Avon) 12(suppl 1):S1–S63CrossRef Frobin W, Brinckmann P, Biggemann M, Tillotson M, Burton K (1997) Precision measurement of disc height, vertebral height and sagittal plane displacement from lateral radiographic views of the lumbar spine. Clin Biomech (Bristol, Avon) 12(suppl 1):S1–S63CrossRef
15.
Zurück zum Zitat Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, Bullinger M, Kaasa S, Leplege A, Prieto L, Sullivan M (1998) Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. International quality of life assessment. J Clin Epidemiol 51:1171–1178PubMedCrossRef Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, Bullinger M, Kaasa S, Leplege A, Prieto L, Sullivan M (1998) Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. International quality of life assessment. J Clin Epidemiol 51:1171–1178PubMedCrossRef
16.
Zurück zum Zitat Gerber M, Crawford NR, Chamberlain RH, Fifield MS, LeHuec JC, Dickman CA (2006) Biomechanical assessment of anterior lumbar interbody fusion with an anterior lumbosacral fixation screw-plate: comparison to stand-alone anterior lumbar interbody fusion and anterior lumbar interbody fusion with pedicle screws in an unstable human cadaver model. Spine 31:762–768PubMedCrossRef Gerber M, Crawford NR, Chamberlain RH, Fifield MS, LeHuec JC, Dickman CA (2006) Biomechanical assessment of anterior lumbar interbody fusion with an anterior lumbosacral fixation screw-plate: comparison to stand-alone anterior lumbar interbody fusion and anterior lumbar interbody fusion with pedicle screws in an unstable human cadaver model. Spine 31:762–768PubMedCrossRef
17.
Zurück zum Zitat Inoue S, Watanabe T, Hirose A, Tanaka T, Matsui N, Saegusa O, Sho E (1984) Anterior discectomy and interbody fusion for lumbar disc herniation. A review of 350 cases. Clin Orthop Relat Res (183):22–31 Inoue S, Watanabe T, Hirose A, Tanaka T, Matsui N, Saegusa O, Sho E (1984) Anterior discectomy and interbody fusion for lumbar disc herniation. A review of 350 cases. Clin Orthop Relat Res (183):22–31
18.
Zurück zum Zitat Jackson RP, McManus AC (1994) Radiographic analysis of sagittal plane alignment and balance in standing volunteers and patients with low back pain matched for age, sex, and size. A prospective controlled clinical study. Spine 19:1611–1618PubMedCrossRef Jackson RP, McManus AC (1994) Radiographic analysis of sagittal plane alignment and balance in standing volunteers and patients with low back pain matched for age, sex, and size. A prospective controlled clinical study. Spine 19:1611–1618PubMedCrossRef
19.
Zurück zum Zitat Kumar A, Kozak JA, Doherty BJ, Dickson JH (1993) Interspace distraction and graft subsidence after anterior lumbar fusion with femoral strut allograft. Spine 18:2393–2400PubMedCrossRef Kumar A, Kozak JA, Doherty BJ, Dickson JH (1993) Interspace distraction and graft subsidence after anterior lumbar fusion with femoral strut allograft. Spine 18:2393–2400PubMedCrossRef
20.
Zurück zum Zitat Kuslich SD, Ulstrom CL, Griffith SL, Ahern JW, Dowdle JD (1998) The Bagby and Kuslich method of lumbar interbody fusion. History, techniques, and 2-year follow-up results of a United States prospective, multicenter trial. Spine 23:1267–1278 (discussion 1279)PubMedCrossRef Kuslich SD, Ulstrom CL, Griffith SL, Ahern JW, Dowdle JD (1998) The Bagby and Kuslich method of lumbar interbody fusion. History, techniques, and 2-year follow-up results of a United States prospective, multicenter trial. Spine 23:1267–1278 (discussion 1279)PubMedCrossRef
21.
Zurück zum Zitat Lee SH, Choi WG, Lim SR, Kang HY, Shin SW (2004) Minimally invasive anterior lumbar interbody fusion followed by percutaneous pedicle screw fixation for isthmic spondylolisthesis. Spine J 4:644–649PubMedCrossRef Lee SH, Choi WG, Lim SR, Kang HY, Shin SW (2004) Minimally invasive anterior lumbar interbody fusion followed by percutaneous pedicle screw fixation for isthmic spondylolisthesis. Spine J 4:644–649PubMedCrossRef
22.
Zurück zum Zitat Legaye J, Duval-Beaupere G, Hecquet J, Marty C (1998) Pelvic incidence: a fundamental pelvic parameter for three-dimensional regulation of spinal sagittal curves. Eur Spine J 7:99–103PubMedCrossRef Legaye J, Duval-Beaupere G, Hecquet J, Marty C (1998) Pelvic incidence: a fundamental pelvic parameter for three-dimensional regulation of spinal sagittal curves. Eur Spine J 7:99–103PubMedCrossRef
23.
Zurück zum Zitat Madan SS, Boeree NR (2003) Comparison of instrumented anterior interbody fusion with instrumented circumferential lumbar fusion. Eur Spine J 12:567–575PubMedCrossRef Madan SS, Boeree NR (2003) Comparison of instrumented anterior interbody fusion with instrumented circumferential lumbar fusion. Eur Spine J 12:567–575PubMedCrossRef
24.
Zurück zum Zitat Madan SS, Harley JM, Boeree NR (2003) Anterior lumbar interbody fusion: does stable anterior fixation matter? Eur Spine J 12:386–392PubMedCrossRef Madan SS, Harley JM, Boeree NR (2003) Anterior lumbar interbody fusion: does stable anterior fixation matter? Eur Spine J 12:386–392PubMedCrossRef
25.
Zurück zum Zitat Mayer HM (1997) A new microsurgical technique for minimally invasive anterior lumbar interbody fusion. Spine 22:691–699 (discussion 700)PubMedCrossRef Mayer HM (1997) A new microsurgical technique for minimally invasive anterior lumbar interbody fusion. Spine 22:691–699 (discussion 700)PubMedCrossRef
26.
Zurück zum Zitat Nachemson A, Zdeblick TA, O’Brien JP (1996) Lumbar disc disease with discogenic pain. What surgical treatment is most effective? Spine 21:1835–1838PubMed Nachemson A, Zdeblick TA, O’Brien JP (1996) Lumbar disc disease with discogenic pain. What surgical treatment is most effective? Spine 21:1835–1838PubMed
27.
Zurück zum Zitat Natarajan RN, Andersson GB (1999) The influence of lumbar disc height and cross-sectional area on the mechanical response of the disc to physiologic loading. Spine 24:1873–1881PubMedCrossRef Natarajan RN, Andersson GB (1999) The influence of lumbar disc height and cross-sectional area on the mechanical response of the disc to physiologic loading. Spine 24:1873–1881PubMedCrossRef
28.
Zurück zum Zitat Newman MH, Grinstead GL (1992) Anterior lumbar interbody fusion for internal disc disruption. Spine 17:831–833PubMedCrossRef Newman MH, Grinstead GL (1992) Anterior lumbar interbody fusion for internal disc disruption. Spine 17:831–833PubMedCrossRef
29.
Zurück zum Zitat Oxland TR, Lund T (2000) Biomechanics of stand-alone cages and cages in combination with posterior fixation: a literature review. Eur Spine J 9(suppl 1):S95–S101PubMedCrossRef Oxland TR, Lund T (2000) Biomechanics of stand-alone cages and cages in combination with posterior fixation: a literature review. Eur Spine J 9(suppl 1):S95–S101PubMedCrossRef
30.
Zurück zum Zitat Penta M, Fraser RD (1997) Anterior lumbar interbody fusion. A minimum 10-year follow-up. Spine 22:2429–2434PubMedCrossRef Penta M, Fraser RD (1997) Anterior lumbar interbody fusion. A minimum 10-year follow-up. Spine 22:2429–2434PubMedCrossRef
31.
Zurück zum Zitat Rao RD, David KS, Wang M (2005) Biomechanical changes at adjacent segments following anterior lumbar interbody fusion using tapered cages. Spine 30:2772–2776PubMedCrossRef Rao RD, David KS, Wang M (2005) Biomechanical changes at adjacent segments following anterior lumbar interbody fusion using tapered cages. Spine 30:2772–2776PubMedCrossRef
32.
Zurück zum Zitat Regan JJ, Aronoff RJ, Ohnmeiss DD, Sengupta DK (1999) Laparoscopic approach to L4-L5 for interbody fusion using BAK cages: experience in the first 58 cases. Spine 24:2171–2174PubMedCrossRef Regan JJ, Aronoff RJ, Ohnmeiss DD, Sengupta DK (1999) Laparoscopic approach to L4-L5 for interbody fusion using BAK cages: experience in the first 58 cases. Spine 24:2171–2174PubMedCrossRef
33.
Zurück zum Zitat Thalgott JS, Klezl Z, Timlin M, Giuffre JM (2002) Anterior lumbar interbody fusion with processed sea coral (coralline hydroxyapatite) as part of a circumferential fusion. Spine 27:E518–525 (discussion E526–517)PubMedCrossRef Thalgott JS, Klezl Z, Timlin M, Giuffre JM (2002) Anterior lumbar interbody fusion with processed sea coral (coralline hydroxyapatite) as part of a circumferential fusion. Spine 27:E518–525 (discussion E526–517)PubMedCrossRef
34.
Zurück zum Zitat Tiusanen H, Seitsalo S, Osterman K, Soini J (1996) Anterior interbody lumbar fusion in severe low back pain. Clin Orthop Relat Res (324):153–163 Tiusanen H, Seitsalo S, Osterman K, Soini J (1996) Anterior interbody lumbar fusion in severe low back pain. Clin Orthop Relat Res (324):153–163
35.
Zurück zum Zitat Tsantrizos A, Andreou A, Aebi M, Steffen T (2000) Biomechanical stability of five stand-alone anterior lumbar interbody fusion constructs. Eur Spine J 9:14–22PubMedCrossRef Tsantrizos A, Andreou A, Aebi M, Steffen T (2000) Biomechanical stability of five stand-alone anterior lumbar interbody fusion constructs. Eur Spine J 9:14–22PubMedCrossRef
36.
Zurück zum Zitat Turner JA, Ersek M, Herron L, Haselkorn J, Kent D, Ciol MA, Deyo R (1992) Patient outcomes after lumbar spinal fusions. Jama 268:907–911PubMedCrossRef Turner JA, Ersek M, Herron L, Haselkorn J, Kent D, Ciol MA, Deyo R (1992) Patient outcomes after lumbar spinal fusions. Jama 268:907–911PubMedCrossRef
37.
Zurück zum Zitat Vazquez RM, Gireesan GT (2003) Balloon-assisted endoscopic retroperitoneal gasless (BERG) technique for anterior lumbar interbody fusion (ALIF). Surg Endosc 17:268–272PubMedCrossRef Vazquez RM, Gireesan GT (2003) Balloon-assisted endoscopic retroperitoneal gasless (BERG) technique for anterior lumbar interbody fusion (ALIF). Surg Endosc 17:268–272PubMedCrossRef
38.
Zurück zum Zitat Vialle R, Levassor N, Rillardon L, Templier A, Skalli W, Guigui P (2005) Radiographic analysis of the sagittal alignment and balance of the spine in asymptomatic subjects. J Bone Joint Surg Am 87:260–267PubMedCrossRef Vialle R, Levassor N, Rillardon L, Templier A, Skalli W, Guigui P (2005) Radiographic analysis of the sagittal alignment and balance of the spine in asymptomatic subjects. J Bone Joint Surg Am 87:260–267PubMedCrossRef
39.
Zurück zum Zitat Vishteh AG, Crawford NR, Chamberlain RH, Thramann JJ, Park SC, Craigo JB, Sonntag VK, Dickman CA (2005) Biomechanical comparison of anterior versus posterior lumbar threaded interbody fusion cages. Spine 30:302–310PubMedCrossRef Vishteh AG, Crawford NR, Chamberlain RH, Thramann JJ, Park SC, Craigo JB, Sonntag VK, Dickman CA (2005) Biomechanical comparison of anterior versus posterior lumbar threaded interbody fusion cages. Spine 30:302–310PubMedCrossRef
40.
Zurück zum Zitat Ware J, Kosinski M, Turner-Bowker D et al (2002) How to score version 2 of the SF-12® Health Survey, Lincoln, RI, Qualimetric Inc., ISBN 1-891810-10-3 Ware J, Kosinski M, Turner-Bowker D et al (2002) How to score version 2 of the SF-12® Health Survey, Lincoln, RI, Qualimetric Inc., ISBN 1-891810-10-3
41.
Zurück zum Zitat Weber J, Vieweg U (2006) Anterior lumbar interbody fusion (ALIF) using a cage with stabilization. Z Orthop Ihre Grenzgeb 144:40–45PubMedCrossRef Weber J, Vieweg U (2006) Anterior lumbar interbody fusion (ALIF) using a cage with stabilization. Z Orthop Ihre Grenzgeb 144:40–45PubMedCrossRef
42.
Zurück zum Zitat Yone K, Sakou T, Kawauchi Y, Yamaguchi M, Yanase M (1996) Indication of fusion for lumbar spinal stenosis in elderly patients and its significance. Spine 21:242–248PubMedCrossRef Yone K, Sakou T, Kawauchi Y, Yamaguchi M, Yanase M (1996) Indication of fusion for lumbar spinal stenosis in elderly patients and its significance. Spine 21:242–248PubMedCrossRef
43.
Zurück zum Zitat Yorimitsu E, Chiba K, Toyama Y, Hirabayashi K (2001) Long-term outcomes of standard discectomy for lumbar disc herniation: a follow-up study of more than 10 years. Spine 26:652–657PubMedCrossRef Yorimitsu E, Chiba K, Toyama Y, Hirabayashi K (2001) Long-term outcomes of standard discectomy for lumbar disc herniation: a follow-up study of more than 10 years. Spine 26:652–657PubMedCrossRef
44.
Zurück zum Zitat Zanoli G, Stromqvist B, Jonsson B (2001) Visual analog scales for interpretation of back and leg pain intensity in patients operated for degenerative lumbar spine disorders. Spine 26:2375–2380PubMedCrossRef Zanoli G, Stromqvist B, Jonsson B (2001) Visual analog scales for interpretation of back and leg pain intensity in patients operated for degenerative lumbar spine disorders. Spine 26:2375–2380PubMedCrossRef
45.
Zurück zum Zitat Zdeblick TA, David SM (2000) A prospective comparison of surgical approach for anterior L4-L5 fusion: laparoscopic versus mini anterior lumbar interbody fusion. Spine 25:2682–2687PubMedCrossRef Zdeblick TA, David SM (2000) A prospective comparison of surgical approach for anterior L4-L5 fusion: laparoscopic versus mini anterior lumbar interbody fusion. Spine 25:2682–2687PubMedCrossRef
Metadaten
Titel
Early outcomes after ALIF with cage and plate in discogenic low back pain: a quantitative analysis
verfasst von
S. Champain
V. Fière
A. Mitulescu
P. Schmitt
W. Skalli
Publikationsdatum
01.04.2008
Verlag
Springer-Verlag
Erschienen in
European Journal of Orthopaedic Surgery & Traumatology / Ausgabe 3/2008
Print ISSN: 1633-8065
Elektronische ISSN: 1432-1068
DOI
https://doi.org/10.1007/s00590-007-0283-4

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