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European Journal of Applied Physiology

Erschienen in:

01.03.2013 | Original Article

Effects of a high-carbohydrate versus high-protein meal on acute responses to hypoxia at rest and exercise

verfasst von: Keyne Charlot, Aurélien Pichon, Jean-Paul Richalet, Didier Chapelot

Erschienen in: European Journal of Applied Physiology | Ausgabe 3/2013

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Abstract

A carbohydrate (CHO) solution consumed before exposure to hypoxia has been reported to reduce arterial oxygen desaturation at rest. The purpose of this study was to determine whether this effect occurred during exercise and when the CHO load is part of a meal. Eleven male subjects (mean age 20.1 ± 1.8 years, BMI 24.3 ± 2.4 kg m²) consumed either a high-CHO (2,340 kJ, 70 % CHO, 12 % protein) or an isoenergetic high-protein (35 % CHO, 48 % protein) breakfast meal 60 min before being exposed to 15 min of hypoxia (F_IO₂ = 13.5 %) followed by 30 min of exercise in hypoxia (60 % of \( \dot{V}{\text{O}}_{{2{ \max }}} \)). Saturation of oxygen via a pulse oxymeter (SpO₂), ventilatory parameters, substrate oxidation, interstitial glucose concentrations, and heart rate variability (HRV) were monitored continuously during the whole session. Results showed no effect from the type of meal on SpO₂ at rest but a 3.1 ± 0.4 % reduction of desaturation during exercise (P < 0.005) compared to the high-protein version. This was associated with higher levels of ventilation (P < 0.05) and CO₂ production (P < 0.01). Glucose oxidation was higher after the high-CHO than the high-protein breakfast over the whole session (+19.4 + 4.0 %, P < 0.0001), whereas the interstitial glucose levels were increased only at rest (P < 0.001). HRV indices were not different between conditions. In conclusion, a high-CHO meal consumed prior to moderate exercise in hypoxia condition reduced oxygen desaturation compared to a high-protein meal.

Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF, Dempsey JA (2006) Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 575:937–952PubMedCrossRef

Baldari C, Bonavolonta V, Emerenziani GP, Gallotta MC, Silva AJ, Guidetti L (2009) Accuracy, reliability, linearity of Accutrend and Lactate Pro versus EBIO plus analyzer. Eur J Appl Physiol 107:105–111PubMedCrossRef

Beidleman BA, Rock PB, Muza SR, Fulco CS, Gibson LL, Kamimori GH, Cymerman A (2002) Substrate oxidation is altered in women during exercise upon acute altitude exposure. Med Sci Sports Exerc 34:430–437PubMedCrossRef

Bickerman HA, Bouvet W, Harrer CJ, Oyler JR, Seitz CP (1945) Aviation nutrition studies. 1. Effects of pre-flight and in-flight means of varying compositions with respect to carbohydrate, protein and fat. Aviat Med 16:69–84

Bigard AX, Douce P, Merino D, Lienhard F, Guezennec CY (1996) Changes in dietary protein intake fail to prevent decrease in muscle growth induced by severe hypoxia in rats. J Appl Physiol 80:208–215PubMed

Billat LV (1996) Use of blood lactate measurements for prediction of exercise performance and for control of training. Recommendations for long-distance running. Sports Med 22:157–175PubMedCrossRef

Borg G (1970) Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med 2:92–98PubMed

Bouissou P, Guezennec CY, Defer G, Pesquies P (1987) Oxygen consumption, lactate accumulation, and sympathetic response during prolonged exercise under hypoxia. Int J Sports Med 8:266–269PubMedCrossRef

Boyne MS, Silver DM, Kaplan J, Saudek CD (2003) Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor. Diabetes 52:2790–2794PubMedCrossRef

Brooks GA, Wolfel EE, Groves BM, Bender PR, Butterfield GE, Cymerman A, Mazzeo RS, Sutton JR, Wolfe RR, Reeves JT (1992) Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m. J Appl Physiol 72:2435–2445PubMed

Calbet JA, De Paz JA, Garatachea N, Cabeza de Vaca S, Chavarren J (2003) Anaerobic energy provision does not limit Wingate exercise performance in endurance-trained cyclists. J Appl Physiol 94:668–676PubMed

Chapman RF, Stager JM, Tanner DA, Stray-Gundersen J, Levine BD (2011) Impairment of 3,000 m run time at altitude is influenced by arterial oxyhemoglobin saturation. Med Sci Sports Exerc 43:1649–1656PubMedCrossRef

Charlot K, Pichon A, Chapelot D (2011) Exercise prior to a freely requested meal modifies pre and postprandial glucose profile, substrate oxidation and sympathovagal balance. Nutr Metab (Lond) 8:66CrossRef

Clarke WL, Anderson S, Farhy L, Breton M, Gonder-Frederick L, Cox D, Kovatchev B (2005) Evaluating the clinical accuracy of two continuous glucose sensors using continuous glucose-error grid analysis. Diabetes Care 28:2412–2417PubMedCrossRef

Eckberg DL (1997) Sympathovagal balance: a critical appraisal. Circulation 96:3224–3232PubMedCrossRef

Eckman M, Barach B et al (1945) Effect of diet on altitude tolerance. J Aviat Med 16:328–340PubMed

Favret F, Richalet JP (2007) Exercise and hypoxia: the role of the autonomic nervous system. Respir Physiol Neurobiol 158:280–286PubMedCrossRef

Ferrannini E (1988) The theoretical bases of indirect calorimetry: a review. Metabolism 37:287–301PubMedCrossRef

Friedmann B, Bauer T, Menold E, Bartsch P (2004) Exercise with the intensity of the individual anaerobic threshold in acute hypoxia. Med Sci Sports Exerc 36:1737–1742PubMedCrossRef

Geoffrey M, Brazg R, Richard W (2011) FreeStyle Navigator Continuous Glucose Monitoring System with TRUstart algorithm, a 1-hour warm-up time. J Diabetes Sci Technol 5:99–106PubMed

Golja P, Flander P, Klemenc M, Maver J, Princi T (2008) Carbohydrate ingestion improves oxygen delivery in acute hypoxia. High Alt Med Biol 9:53–62PubMedCrossRef

Gonzalez NC, Clancy RL, Moue Y, Richalet JP (1998) Increasing maximal heart rate increases maximal O₂ uptake in rats acclimatized to simulated altitude. J Appl Physiol 84:164–168PubMed

Goodwin ML, Harris JE, Hernandez A, Gladden LB (2007) Blood lactate measurements and analysis during exercise: a guide for clinicians. J Diabetes Sci Technol 1:558–569PubMed

Hansen JE, Hartley LH, Hogan RP 3rd (1972) Arterial oxygen increase by high-carbohydrate diet at altitude. J Appl Physiol 33:441–445PubMed

Hochachka PW, Beatty CL, Burelle Y, Trump ME, McKenzie DC, Matheson GO (2002) The lactate paradox in human high-altitude physiological performance. News Physiol Sci 17:122–126PubMed

Hoppeler H, Vogt M (2001) Hypoxia training for sea-level performance. Training high-living low. Adv Exp Med Biol 502:61–73PubMed

Jeukendrup AE, Wallis GA (2005) Measurement of substrate oxidation during exercise by means of gas exchange measurements. Int J Sports Med 26(Suppl 1):S28–S37PubMedCrossRef

Karelis AD, Smith JW, Passe DH, Peronnet F (2010) Carbohydrate administration and exercise performance: what are the potential mechanisms involved? Sports Med 40:747–763PubMedCrossRef

Klemenc M, Golja P (2011) Baroreflex sensitivity in acute hypoxia and carbohydrate loading. Eur J Appl Physiol 111:2509–2515PubMedCrossRef

Klemenc M, Maver J, Princi T, Flander P, Golja P (2008) The effect of sucrose ingestion on autonomic nervous system function in young subjects during acute moderate hypoxia. Eur J Appl Physiol 104:803–812PubMedCrossRef

Kovatchev BP, Shields D, Breton M (2009) Graphical and numerical evaluation of continuous glucose sensing time lag. Diabetes Technol Ther 11:139–143PubMedCrossRef

Larsen PD, Tzeng YC, Sin PY, Galletly DC (2010) Respiratory sinus arrhythmia in conscious humans during spontaneous respiration. Respir Physiol Neurobiol 174:111–118PubMedCrossRef

Lawless NP, Dillard TA, Torrington KG, Davis HQ, Kamimori G (1999) Improvement in hypoxemia at 4600 meters of simulated altitude with carbohydrate ingestion. Aviat Space Environ Med 70:874–878PubMed

Lundby C, Van Hall G (2002) Substrate utilization in sea level residents during exercise in acute hypoxia and after 4 weeks of acclimatization to 4100 m. Acta Physiol Scand 176:195–201PubMedCrossRef

McNarry MA, Lewis MJ (2012) Heart rate variability reproducibility during exercise. Physiol Meas 33:1123–1133PubMedCrossRef

Mollard P, Bourdillon N, Letournel M, Herman H, Gibert S, Pichon A, Woorons X, Richalet JP (2010) Validity of arterialized earlobe blood gases at rest and exercise in normoxia and hypoxia. Respir Physiol Neurobiol 172:179–183PubMedCrossRef

Montano N, Ruscone TG, Porta A, Lombardi F, Pagani M, Malliani A (1994) Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. Circulation 90:1826–1831PubMedCrossRef

Morel OE, Aubert R, Richalet JP, Chapelot D (2005) Simulated high altitude selectively decreases protein intake and lean mass gain in rats. Physiol Behav 86:145–153PubMedCrossRef

Niskanen JP, Tarvainen MP, Ranta-Aho PO, Karjalainen PA (2004) Software for advanced HRV analysis. Comput Methods Programs Biomed 76:73–81PubMedCrossRef

Oliver SJ, Golja P, Macdonald JH (2012) Carbohydrate supplementation and exercise performance at high altitude: a randomized controlled trial. High Alt Med Biol 13:22–31PubMedCrossRef

Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell’Orto S, Piccaluga E et al (1986) Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 59:178–193PubMedCrossRef

Paul D, Jacobs KA, Geor RJ, Hinchcliff KW (2003) No effect of pre-exercise meal on substrate metabolism and time trial performance during intense endurance exercise. Int J Sport Nutr Exerc Metab 13:489–503PubMed

Peronnet F, Massicotte D (1991) Table of nonprotein respiratory quotient: an update. Can J Sport Sci 16:23–29PubMed

Peronnet F, Massicotte D, Folch N, Melin B, Koulmann N, Jimenez C, Bourdon L, Launay JC, Savourey G (2006) Substrate utilization during prolonged exercise with ingestion of (13)C-glucose in acute hypobaric hypoxia (4,300 m). Eur J Appl Physiol 97:527–534PubMedCrossRef

Pinna GD, Maestri R, Torunski A, Danilowicz-Szymanowicz L, Szwoch M, La Rovere MT, Raczak G (2007) Heart rate variability measures: a fresh look at reliability. Clin Sci (Lond) 113:131–140CrossRef

Pitzalis MV, Mastropasqua F, Massari F, Forleo C, Di Maggio M, Passantino A, Colombo R, Di Biase M, Rizzon P (1996) Short- and long-term reproducibility of time and frequency domain heart rate variability measurements in normal subjects. Cardiovasc Res 32:226–233PubMedCrossRef

Pivik RT, Dykman RA (2004) Cardiovascular effects of morning nutrition in preadolescents. Physiol Behav 82:295–302PubMedCrossRef

Pivik RT, Dykman RA, Tennal K, Gu Y (2006) Skipping breakfast: gender effects on resting heart rate measures in preadolescents. Physiol Behav 89:270–280PubMedCrossRef

Pyne DB, Boston T, Martin DT, Logan A (2000) Evaluation of the Lactate Pro blood lactate analyser. Eur J Appl Physiol 82:112–116PubMedCrossRef

Rebrin K, Steil GM (2000) Can interstitial glucose assessment replace blood glucose measurements? Diabetes Technol Ther 2:461–472PubMedCrossRef

Richalet JP, Larmignat P, Poitrine E, Letournel M, Canoui-Poitrine F (2012) Physiological risk factors for severe high-altitude illness: a prospective cohort study. Am J Respir Crit Care Med 185:192–198PubMedCrossRef

Rowlands DS, Hopkins WG (2002) Effects of high-fat and high-carbohydrate diets on metabolism and performance in cycling. Metabolism 51:678–690PubMedCrossRef

Sinnreich R, Kark JD, Friedlander Y, Sapoznikov D, Luria MH (1998) Five minute recordings of heart rate variability for population studies: repeatability and age-sex characteristics. Heart 80:156–162PubMed

Sutton JR, Coates G, Houston CS (1991) Lake Louise consensus on definition and quantification of altitude illness. In: Sutton JR, Coates G, Houston CS (eds) Hypoxia and mountain medicine. Pergamon Press, New York, pp 327–330

Swenson ER, MacDonald A, Vatheuer M, Maks C, Treadwell A, Allen R, Schoene RB (1997) Acute mountain sickness is not altered by a high carbohydrate diet nor associated with elevated circulating cytokines. Aviat Space Environ Med 68:499–503PubMed

Tanner RK, Fuller KL, Ross ML (2010) Evaluation of three portable blood lactate analysers: lactate Pro, Lactate Scout and Lactate Plus. Eur J Appl Physiol 109:551–559PubMedCrossRef

Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 93:1043–1065

Wehrlin JP, Hallen J (2006) Linear decrease in VO_2max and performance with increasing altitude in endurance athletes. Eur J Appl Physiol 96:404–412PubMedCrossRef

Weippert M, Kumar M, Kreuzfeld S, Arndt D, Rieger A, Stoll R (2010) Comparison of three mobile devices for measuring R–R intervals and heart rate variability: polar S810i, Suunto t6 and an ambulatory ECG system. Eur J Appl Physiol 109:779–786PubMedCrossRef

Weir JB (1949) New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109:1–9PubMed

Welle S, Lilavivat U, Campbell RG (1981) Thermic effect of feeding in man: increased plasma norepinephrine levels following glucose but not protein or fat consumption. Metabolism 30:953–958PubMedCrossRef

Whitley HA, Humphreys SM, Campbell IT, Keegan MA, Jayanetti TD, Sperry DA, MacLaren DP, Reilly T, Frayn KN (1998) Metabolic and performance responses during endurance exercise after high-fat and high-carbohydrate meals. J Appl Physiol 85:418–424PubMed

Titel: Effects of a high-carbohydrate versus high-protein meal on acute responses to hypoxia at rest and exercise
verfasst von: Keyne Charlot
Aurélien Pichon
Jean-Paul Richalet
Didier Chapelot
Publikationsdatum: 01.03.2013
Verlag: Springer-Verlag
Erschienen in: European Journal of Applied Physiology / Ausgabe 3/2013
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-012-2472-z

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