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Zeitschrift für Rheumatologie

Erschienen in:

01.09.2014 | Originalien

Meta-analysis of functional MBL polymorphisms

Associations with rheumatoid arthritis and primary Sjögren’s syndrome

verfasst von: G.G. Song, S.-C. Bae, Y.H. Seo, J.-H. Kim, S.J. Choi, J.D. Ji, Y.H. Lee, MD, PhD

Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 7/2014

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Abstract

Objective

The aim of this study was to determine whether functional mannose-binding lectin gene (MBL) polymorphisms are associated with the susceptibility to rheumatoid arthritis (RA) or primary Sjögren’s syndrome (pSS).

Methods

A meta-analysis was conducted to investigate the potential association of RA or pSS with MBL polymorphisms, including the codon 54 (allele B), codon 57 (allele C), and codon 52 (allele D) variants of exon 1, and the − 550 (allele L) and − 221 (allele X) promoter variants.

Results

A total of 12 comparative studies, including eight RA (1623 patients and 1671 controls) and four pSS (280 patients and 516 controls) studies, were included in the meta-analysis. The meta-analysis revealed no association between the MBL B allele and RA in the overall study population (odds ratio [OR] 0.991, 95 % confidence interval [CI] 0.726–1.355, p = 0.957). However, the meta-analysis showed significant associations between the MBL D, H, and X alleles and RA in the overall population (OR 1.708, 95 % CI 1.077–2.707, p = 0.023; OR 1.936, 95 % CI 1.218–3.078, p = 0.005; OR 1.582, 95 % CI 1.216–2.057, p = 0.001, respectively). An association was found between the MBL B allele and pSS in the overall study population (OR 0.691, 95 % CI 0.541–0.917, p = 0.010). Stratification by ethnicity indicated a trend toward an association between the B allele and pSS in European populations, but no association in Asian populations (OR 0.689, 95 % CI 0.465–1.021, p = 0.063; OR 0.896, 95 % CI 0.311–2.562, p = 0.838, respectively).

Conclusion

This meta-analysis demonstrated an association between the MBL D, L, and X alleles and the risk of RA. It also demonstrated an association between the MBL B allele and the susceptibility to pSS, suggesting a protective role of the MBL B allele against the development of pSS.

Fox RI (2005) Sjogren’s syndrome. Lancet 366:321–331PubMedCrossRef

Choi SJ, Rho YH, Ji JD et al (2006) Genome scan meta-analysis of rheumatoid arthritis. Rheumatology (Oxford) 45:166–170

Song GG, Kim JH, Seo YH et al (2014) Meta-analysis of differentially expressed genes in primary Sjogren’s syndrome by using microarray. Hum Immunol 75:98–104PubMedCrossRef

Martiny FL, Veit TD, Brenol CV et al (2012) Mannose-binding lectin gene polymorphisms in Brazilian patients with rheumatoid arthritis. J Rheumatol 39:6–9PubMedCrossRef

Geijn FE van de, Hazes JM, Geleijns K et al (2008) Mannose-binding lectin polymorphisms are not associated with rheumatoid arthritis – confirmation in two large cohorts. Rheumatology (Oxford) 47:1168–1171

Tsutsumi A, Sasaki K, Wakamiya N et al (2001) Mannose-binding lectin gene: polymorphisms in Japanese patients with systemic lupus erythematosus, rheumatoid arthritis and Sjogren’s syndrome. Genes Immun 2:99–104PubMedCrossRef

Horiuchi T, Tsukamoto H, Morita C et al (2000) Mannose binding lectin (MBL) gene mutation is not a risk factor for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Japanese. Genes Immun 1:464–466PubMedCrossRef

Ip WK, Lau YL, Chan SY et al (2000) Mannose-binding lectin and rheumatoid arthritis in southern Chinese. Arthritis Rheum 43:1679–1687PubMedCrossRef

Aittoniemi J, Pertovaara M, Hulkkonen J et al (2002) The significance of mannan-binding lectin gene alleles in patients with primary Sjogren’s syndrome. Scand J Rheumatol 31:362–365PubMedCrossRef

10.

Wang ZY, Morinobu A, Kanagawa S, Kumagai S (2001) Polymorphisms of the mannose binding lectin gene in patients with Sjogren’s syndrome. Ann Rheum Dis 60:483–486PubMedCentralPubMedCrossRef

11.

Mullighan CG, Marshall SE, Welsh KI (2000) Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency. Scand J Immunol 51:111–122PubMedCrossRef

12.

Gupta B, Agrawal C, Raghav SK et al (2005) Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples. J Hum Genet 50:583–591PubMedCrossRef

13.

Stanworth SJ, Donn RP, Hassall A et al (1998) Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis. Br J Rheumatol 37:186–188PubMedCrossRef

14.

Lee YH, Harley JB, Nath SK (2006) Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet 14:364–371PubMedCrossRef

15.

Nath SK, Harley JB, Lee YH (2005) Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum Genet 118:225–234PubMedCrossRef

16.

Lee YH, Rho YH, Choi SJ et al (2006) Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Rheumatol Int 27:157–161PubMedCrossRef

17.

Davey Smith G, Egger M (1997) Meta-analyses of randomised controlled trials. Lancet 350:1182

18.

Egger M, Smith GD, Phillips AN (1997) Meta-analysis: principles and procedures. BMJ 315:1533–1537PubMedCentralPubMedCrossRef

19.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188PubMedCrossRef

20.

Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558PubMedCrossRef

21.

Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634PubMedCentralPubMedCrossRef

22.

Ramos-Casals M, Brito-Zeron P, Soria N et al (2009) Mannose-binding lectin-low genotypes are associated with milder systemic and immunological disease expression in primary Sjogren’s syndrome. Rheumatology (Oxford) 48:65–69

23.

Yoshida K, Komai K, Shiozawa K et al (2011) Role of the MICA polymorphism in systemic lupus erythematosus. Arthritis Rheum 63:3058–3066PubMedCrossRef

24.

Fojtikova M, Novota P, Cejkova P et al (2011) HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population. Rheumatol Int 31:1195–1201PubMedCrossRef

25.

Sanchez E, Torres B, Vilches JR et al (2006) No primary association of MICA polymorphism with systemic lupus erythematosus. Rheumatology (Oxford) 45:1096–1100

26.

Gambelunghe G, Gerli R, Bocci EB et al (2005) Contribution of MHC class I chain-related A (MICA) gene polymorphism to genetic susceptibility for systemic lupus erythematosus. Rheumatology (Oxford) 44:287–292

27.

Ban G, Chu J, Mao C et al (2002) A study of the relationship between MICA gene and systemic lupus erythematosus. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:298–301PubMed

28.

Lopez-Arbesu R, Ballina-Garcia FJ, Alperi-Lopez M et al (2007) MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. Rheumatology (Oxford) 46:426–430

29.

Mok JW, Lee YJ, Kim JY et al (2003) Association of MICA polymorphism with rheumatoid arthritis patients in Koreans. Hum Immunol 64:1190–1194PubMedCrossRef

30.

Singal DP, Li J, Zhang G (2001) Microsatellite polymorphism of the MICA gene and susceptibility to rheumatoid arthritis. Clin Exp Rheumatol 19:451–452PubMed

31.

Ricci-Vitiani L, Vacca A, Potolicchio I et al (2000) MICA gene triplet repeat polymorphism in patients with HLA-B27 positive and negative ankylosing spondylitis from Sardinia. J Rheumatol 27:2193–2197PubMed

32.

Yabuki K, Ota M, Goto K et al (1999) Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative Caucasian patients with ankylosing spondylitis. Hum Immunol 60:83–86PubMedCrossRef

33.

Goto K, Ota M, Ohno S et al (1997) MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane-encoded triplet repeat polymorphism. Tissue Antigens 49:503–507PubMedCrossRef

34.

Lee YH, Witte T, Momot T et al (2005) The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum 52:3966–3974PubMedCrossRef

35.

Garred P, Larsen F, Madsen HO, Koch C (2003) Mannose-binding lectin deficiency – revisited. Mol Immunol 40:73–84PubMedCrossRef

36.

Wiertsema SP, Herpers BL, Veenhoven RH et al (2006) Functional polymorphisms in the mannan-binding lectin 2 gene: effect on MBL levels and otitis media. J Allergy Clin Immunol 117:1344–1350PubMedCrossRef

37.

Madsen HO, Garred P, Thiel S et al (1995) Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J Immunol 155:3013–3020PubMed

38.

Carroll M (2001) Innate immunity in the etiopathology of autoimmunity. Nat Immunol 2:1089–1090PubMedCrossRef

39.

Kilpatrick DC (2002) Mannan-binding lectin and its role in innate immunity. Transfus Med 12:335–352PubMedCrossRef

40.

Lotz M, Roudier J (1989) Epstein-Barr virus and rheumatoid arthritis: cellular and molecular aspects. Rheumatol Int 9:147–152PubMed

41.

Venables PJ, Rigby SP (1997) Viruses in the etiopathogenesis of Sjogren’s syndrome. J Rheumatol Suppl 50:3–5PubMed

42.

Matsushita M, Hijikata M, Matsushita M et al (1998) Association of mannose-binding lectin gene haplotype LXPA and LYPB with interferon-resistant hepatitis C virus infection in Japanese patients. J Hepatol 29:695–700PubMedCrossRef

43.

Garred P, Madsen HO, Balslev U et al (1997) Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin. Lancet 349:236–240PubMedCrossRef

44.

Fischer PB, Ellermann-Eriksen S, Thiel S et al (1994) Mannan-binding protein and bovine conglutinin mediate enhancement of herpes simplex virus type 2 infection in mice. Scand J Immunol 39:439–445PubMedCrossRef

45.

Garred P, Harboe M, Oettinger T et al (1994) Dual role of mannan-binding protein in infections: another case of heterosis? Eur J Immunogenet 21:125–131PubMedCrossRef

Titel: Meta-analysis of functional MBL polymorphisms
Associations with rheumatoid arthritis and primary Sjögren’s syndrome
verfasst von: G.G. Song
S.-C. Bae
Y.H. Seo
J.-H. Kim
S.J. Choi
J.D. Ji
Y.H. Lee, MD, PhD
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Zeitschrift für Rheumatologie / Ausgabe 7/2014
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI: https://doi.org/10.1007/s00393-014-1408-x

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