Background
Amyloid beta imaging
Importance of radiation dosimetry
Previous biodistribution and dosimetry study for PET amyloid imaging
Aim of the present study
Methods
Subjects
Sex | Age (years) | Height (m) | Weight (kg) | BMI (kg/m
2) | History | |
---|---|---|---|---|---|---|
Subject number | ||||||
1 | M | 77 | 1.59 | 61.2 | 24.2 | Surgical removal of gallbladder |
2 | M | 78 | 1.62 | 65 | 24.8 | - |
3 | M | 77 | 1.75 | 74 | 24.2 | - |
4 | F | 70 | 1.46 | 39 | 18.3 | - |
5 | F | 77 | 1.56 | 60.2 | 26.1 | - |
6 | F | 79 | 1.55 | 56 | 23.3 | - |
Mean ± 1 SD | 76.3 ± 3.2 | 1.58 ± 0.75 | 59.2 ± 11.6 | 23.5 ± 2.7 |
Radiochemistry and radioligand purity
PET study
MRI study
Dosimetry
Regions of interest
Organ | Human (MBq-h/MBq) | Mouse (MBq-h/MBq) | ||||||
---|---|---|---|---|---|---|---|---|
Mean ± 1 SD | Subject 1 | Subject 2 | Subject 3 | Subject 4 | Subject 5 | Subject 6 | ||
Adrenal gland | 5.38E−04 ± 2.98E−04 | 9.40E−04 | 8.40E−04 | 5.20E−04 | 3.70E−04 | 4.00E−04 | 1.60E−04 | - |
Brain | 4.20E−02 ± 8.44E−03 | 5.41E−02 | 3.68E−02 | 3.53E−02 | 4.87E−02 | 4.42E−02 | 3.26E−02 | 6.99E−03 |
Breast | 8.40E−03 ± 4.37E−03 | 1.14E−03 | 8.25E−03 | 5.59E−03 | 1.16E−02 | 1.19E−02 | 1.19E−02 | - |
Gallbladder contenta
| 2.22E−01 ± 1.05E−01 | - | 1.49E−01 | 2.27E−01 | 3.88E−01 | 1.16E−01 | 2.31E−01 | - |
Lower large intestine content | 2.12E−02 ± 2.03E−02 | 5.91E−02 | 1.06E−02 | 4.80E−03 | 2.27E−02 | 2.40E−02 | 5.96E−03 | - |
Small intestine content | 8.78E−02 ± 1.08E−01 | 7.40E−02 | 3.74E−02 | 3.34E−02 | 3.06E−01 | 3.36E−02 | 4.25E−02 | 1.22E−01 |
Stomach content | 6.71E−03 ± 2.28E−03 | 5.22E−03 | 6.23E−03 | 9.29E−03 | 9.84E−03 | 4.78E−03 | 4.87E−03 | - |
Upper large intestine content | 2.55E−02 ± 1.89E−02 | 1.48E−02 | 4.88E−02 | 1.01E−02 | 4.99E−02 | 2.04E−02 | 8.85E−03 | - |
Heart content | 1.12.E−02 ± 1.51E−03 | 1.24E−02 | 1.13E−02 | 1.02E−02 | 1.30E−02 | 1.15E−02 | 8.83E−03 | 3.95E−03 |
Heart wall | 7.50E−03 ± 1.84E−03 | 4.63E−03 | 1.00E−02 | 8.84E−03 | 6.75E−03 | 7.28E−03 | 7.49E−03 | 2.39E−03 |
Kidney | 1.34E−02 ± 3.27E−03 | 1.32E−02 | 1.16E−02 | 1.53E−02 | 1.89E−02 | 9.59E−03 | 1.20E−02 | 9.34E−03 |
Liver | 4.92E−01 ± 1.05E−01 | 6.28E−01 | 5.85E−01 | 4.34E−01 | 5.15E−01 | 3.42E−01 | 4.49E−01 | 1.69E−01 |
Lung | 3.55E−02 ± 1.16E−02 | 3.78E−02 | 5.31E−02 | 4.36E−02 | 2.46E−02 | 2.33E−02 | 3.08E−02 | 1.17E−02 |
Muscle | 4.66E−01 ± 3.73E−01 | 9.43E−01 | 5.47E−01 | 7.97E−01 | 5.40E−02 | 4.12E−01 | 4.34E−02 | 1.57E−01 |
Ovaryb
| 5.53E−04 ± 3.79E−05 | - | - | - | 5.70E−04 | 5.10E−04 | 5.80E−04 | - |
Pancreas | 4.13E−03 ± 9.75E−04 | 6.10E−03 | 3.62E−03 | 3.93E−03 | 3.81E−03 | 3.55E−03 | 3.76E−03 | - |
Red marrow | 3.98E−02 ± 4.33E−03 | 4.02E−02 | 3.83E−02 | 3.79E−02 | 4.59E−02 | 4.29E−02 | 3.34E−02 | 1.61E−02 |
Spleen | 5.41E−03 ± 1.74E−03 | 8.64E−03 | 4.88E−03 | 3.83E−03 | 6.01E−03 | 4.77E−03 | 4.30E−03 | 1.28E−03 |
Testisc
| 5.77E−04 ± 4.67E−04 | 7.00E−04 | 6.10E−05 | 9.70E−04 | - | - | - | - |
Thyroid | 3.53E−04 ± 1.55E−04 | 6.30E−04 | 3.70E−04 | 3.60E−04 | 2.40E−04 | 1.80E−04 | 3.40E−04 | - |
Urinary bladder contents | 2.26E−02 ± 8.36E−03 | 1.70E−02 | 2.69E−02 | 1.55E−02 | 3.63E−02 | 2.49E−02 | 1.51E−02 | 6.56E−02 |
Uterus/uterine wallb
| 4.46E−03 ± 1.90E−03 | - | - | - | 6.42E−03 | 2.63E−03 | 4.33E−03 | - |
Remainder of the body | 1.17 ± 3.63E−01 | 7.24E−01 | 1.06 | 9.48E−01 | 1.08 | 1.51 | 1.69 | 2.08 |
Data analysis
Animal experiments
Results and discussion
Biodistribution of [18F]FACT
Estimated dose of [18F]FACT
Human | Mouse | |||
---|---|---|---|---|
All subjects (n= 6) | Male | Female | ||
(n= 3) | (n= 3) | |||
Organ | ||||
Adrenal gland | 1.96E01 ± 2.00 | 2.03E01 | 1.90E01 | 1.35E01 |
Brain | 9.91 ± 1.82 | 8.95 | 1.09E01 | 4.17 |
Breasts | 8.69 ± 2.55 | 6.68 | 1.07E01 | 9.90 |
Gallbladder wall | 3.33E02 ± 2.51E02 | 2.16E02 | 4.50E02 | 1.68E01 |
Lower large intestine wall | 2.52E01 ± 1.26E01 | 2.41E01 | 2.63E01 | 1.57E01 |
Small intestine | 3.36E01 ± 3.07E01 | 2.07E01 | 4.64.E01 | 3.85E01 |
Stomach wall | 1.61E01 ± 3.44 | 1.35E01 | 1.87E01 | 1.39E01 |
Upper large intestine wall | 2.98E01 ± 1.50E01 | 2.36E01 | 3.59E01 | 1.83E01 |
Heart wall | 1.62E01 ± 1.70 | 1.50E01 | 1.74E01 | 8.34 |
Kidneys | 2.01E01 ± 4.30 | 1.85E01 | 2.17E01 | 1.32E01 |
Liver | 7.75E01 ± 1.45E01 | 7.38E01 | 8.11E01 | 2.55E01 |
Lungs | 1.46E01 ± 1.10 | 1.49E01 | 1.43E01 | 7.96 |
Muscle | 1.03E01 ± 1.27 | 1.07E01 | 9.90 | 7.89 |
Ovary | 1.67E01 ± 6.65 | 1.18E01 | 2.16E01 | 1.67E01 |
Pancreas | 2.32E01 ± 3.11 | 2.17E01 | 2.47E01 | 1.45E01 |
Red marrow | 1.31E01 ± 1.70 | 1.16E01 | 1.46E01 | 1.23E01 |
Osteogenic cells | 1.60E01 ± 3.65 | 1.25E01 | 1.95E01 | 1.82E01 |
Skin | 7.30 ± 1.39 | 5.99 | 8.60 | 8.70 |
Spleen | 1.37E01 ± 2.48 | 1.27E01 | 1.48E01 | 7.83 |
Testis | 7.32 ± 2.16 | 7.32 | - | 1.15E01 |
Thymus | 1.00E01 ± 1.85 | 8.37 | 1.16E01 | 1.08E01 |
Thyroid | 8.36 ± 1.38 | 8.86 | 7.86 | 1.10E01 |
Urinary bladder wall | 2.23E01 ± 7.33 | 1.81E01 | 2.66E01 | 4.31E01 |
Uterus | 1.67E01 ± 8.13 | 1.14E01 | 2.19E01 | 1.77E01 |
Total body | 1.38E01 ± 1.63 | 1.22E01 | 1.53E01 | 1.22E01 |
Effective dose (μSv/MBq) | 1.86E01 ± 3.74 | 1.64E01 | 2.09E01 | 1.48E01 |