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Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 8/2016

30.11.2015 | Short Communication

Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents

verfasst von: Johan Isaksson, Elena L. Grigorenko, Lars Oreland, Britt af Klinteberg, Roman A. Koposov, Vladislav Ruchkin

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 8/2016

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Abstract

Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.
Literatur
1.
Zurück zum Zitat Stouthamer-Loeber M, Loeber R, Wei E, Farrington DP, Wikstrorm PO (2002) Risk and promotive effects in the explanation of persistent serious delinquency in boys. J Consult Clin Psychol 70:111–123CrossRefPubMed Stouthamer-Loeber M, Loeber R, Wei E, Farrington DP, Wikstrorm PO (2002) Risk and promotive effects in the explanation of persistent serious delinquency in boys. J Consult Clin Psychol 70:111–123CrossRefPubMed
2.
Zurück zum Zitat Frick PJ, White SF (2008) Research review: the importance of callous-unemotional traits for developmental models of aggressive and antisocial behavior. J Child Psychol Psychiatry 49:359–375CrossRefPubMed Frick PJ, White SF (2008) Research review: the importance of callous-unemotional traits for developmental models of aggressive and antisocial behavior. J Child Psychol Psychiatry 49:359–375CrossRefPubMed
3.
Zurück zum Zitat Klahr AM, Burt SA (2014) Practitioner Review: Evaluation of the known behavioral heterogeneity in conduct disorder to improve its assessment and treatment. J Child Psychol Psychiatry 55:1300–1310CrossRefPubMed Klahr AM, Burt SA (2014) Practitioner Review: Evaluation of the known behavioral heterogeneity in conduct disorder to improve its assessment and treatment. J Child Psychol Psychiatry 55:1300–1310CrossRefPubMed
4.
Zurück zum Zitat Gabel S, Stadler J, Bjorn J, Shindledecker R, Bowden C (1993) Dopamine-beta-hydroxylase in behaviorally disturbed youth. Relationship between teacher and parent ratings. Biol Psychiatry 34:434–442CrossRefPubMed Gabel S, Stadler J, Bjorn J, Shindledecker R, Bowden C (1993) Dopamine-beta-hydroxylase in behaviorally disturbed youth. Relationship between teacher and parent ratings. Biol Psychiatry 34:434–442CrossRefPubMed
5.
Zurück zum Zitat Galvin M, Ten Eyck R, Shekhar A et al (1995) Serum dopamine beta hydroxylase and maltreatment in psychiatrically hospitalized boys. Child Abuse Negl 19:821–832CrossRefPubMed Galvin M, Ten Eyck R, Shekhar A et al (1995) Serum dopamine beta hydroxylase and maltreatment in psychiatrically hospitalized boys. Child Abuse Negl 19:821–832CrossRefPubMed
6.
Zurück zum Zitat Cubells JF, Zabetian CP (2004) Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology. Psychopharmacology 174:463–476CrossRefPubMed Cubells JF, Zabetian CP (2004) Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology. Psychopharmacology 174:463–476CrossRefPubMed
7.
Zurück zum Zitat Kwon HJ, Lim MH (2013) Association between dopamine beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children. Genet Test Mol Biomarkers 17:529–534CrossRefPubMed Kwon HJ, Lim MH (2013) Association between dopamine beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children. Genet Test Mol Biomarkers 17:529–534CrossRefPubMed
8.
Zurück zum Zitat Hess C, Reif A, Strobel A et al (2009) A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders. J Neural Transm 116:121–130CrossRefPubMed Hess C, Reif A, Strobel A et al (2009) A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders. J Neural Transm 116:121–130CrossRefPubMed
9.
Zurück zum Zitat Gong P, Liu J, Li S, Zhou X (2013) Dopamine beta-hydroxylase gene modulates individuals’ empathic ability. Soc Cogn Affect Neurosci 9:1341–1345CrossRefPubMedPubMedCentral Gong P, Liu J, Li S, Zhou X (2013) Dopamine beta-hydroxylase gene modulates individuals’ empathic ability. Soc Cogn Affect Neurosci 9:1341–1345CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126:51–90CrossRefPubMed Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126:51–90CrossRefPubMed
11.
Zurück zum Zitat Grigorenko EL, De Young CG, Eastman M et al (2010) Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover. Aggress Behav 36:158–176PubMed Grigorenko EL, De Young CG, Eastman M et al (2010) Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover. Aggress Behav 36:158–176PubMed
12.
Zurück zum Zitat Ruchkin V, Koposov R, Vermeiren R, Schwab-Stone M (2003) Psychopathology and age at onset of conduct problems in juvenile delinquents. J Clin Psychiatry 64:913–920CrossRefPubMed Ruchkin V, Koposov R, Vermeiren R, Schwab-Stone M (2003) Psychopathology and age at onset of conduct problems in juvenile delinquents. J Clin Psychiatry 64:913–920CrossRefPubMed
13.
Zurück zum Zitat Frick PJ, Hare RD (2001) The antisocial process screening device. Multi-Health Systems, Toronto Frick PJ, Hare RD (2001) The antisocial process screening device. Multi-Health Systems, Toronto
14.
Zurück zum Zitat Lynam DR (1997) Pursuing the psychopath: capturing the fledgling psychopath in a nomological net. J Abnormal Psychol 106:425–438CrossRef Lynam DR (1997) Pursuing the psychopath: capturing the fledgling psychopath in a nomological net. J Abnormal Psychol 106:425–438CrossRef
17.
Zurück zum Zitat Sharp C, Kine S (2008) The assessment of juvenile psychopathy: strengths and weaknesses of currently used questionnaire measures. Child Adolesc Mental Health Uk 13:85–95CrossRef Sharp C, Kine S (2008) The assessment of juvenile psychopathy: strengths and weaknesses of currently used questionnaire measures. Child Adolesc Mental Health Uk 13:85–95CrossRef
Metadaten
Titel
Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents
verfasst von
Johan Isaksson
Elena L. Grigorenko
Lars Oreland
Britt af Klinteberg
Roman A. Koposov
Vladislav Ruchkin
Publikationsdatum
30.11.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 8/2016
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-015-0664-3

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