Erschienen in:
30.11.2015 | Short Communication
Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents
verfasst von:
Johan Isaksson, Elena L. Grigorenko, Lars Oreland, Britt af Klinteberg, Roman A. Koposov, Vladislav Ruchkin
Erschienen in:
European Archives of Psychiatry and Clinical Neuroscience
|
Ausgabe 8/2016
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Abstract
Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.