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Investigational New Drugs

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01.10.2011 | SHORT REPORT

Fatal interstitial pneumonitis in a patient with relapsed diffuse large B cell lymphoma following yttrium-90 ibritumomab tiuxetan

verfasst von: Moon Jin Kim, Gyeong-Won Lee, Jong Woo Seo, Hyun-Jung Kim, Sung-Nam Lim, Cheolwon Suh

Erschienen in: Investigational New Drugs | Ausgabe 5/2011

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Summary

There is no previous report of fatal interstitial pneumonitis related to the administration of yttirum-90 ibritumomab tiuxetan. We report first case of fatal interstitial pneumonitis in a 35-year-old female patient with relapsed diffuse large B cell lymphoma following yttrium-90 ibritumomab tiuxetan. A pathological evaluation through a surgical lung biopsy demonstrated a “interstitial pneumonitis” pattern. Although high-dose methylprednisolone was administered, she died due to acute respiratory distress syndrome, secondary to radioimmunotherapy-induced interstitial pneumonitis. In this report, we discuss the etiology, diagnosis, and management of radioimmunotherapy-induced interstitial pneumonitis.

Marcus R (2005) Use of 90Y-ibritumomab tiuxetan in non-Hodgkin’s lymphoma. Semin Oncol 32:S36–S43PubMedCrossRef

Witzig TE, Gordon LI, Cabanillas F, Czuczman MS, Emmanouilides C, Joyce R et al (2002) Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin’s lymphoma. J Clin Oncol 20:2453–2463PubMedCrossRef

Wiseman GA, Kornmehl E, Leigh B, Erwin WD, Podoloff DA, Spies S et al (2003) Radiation dosimetry results and safety correlations from 90Y-ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory non-Hodgkin’s lymphoma: combined data from 4 clinical trials. J Nucl Med 44:465–474PubMed

Macklis RM, Pohlman B (2006) Radioimmunotherapy for non-Hodgkin’s lymphoma: a review for radiation oncologists. Int J Radiat Oncol Biol Phys 66:833–841PubMedCrossRef

Burton C, Kaczmarski R, Jan-Mohamed R (2003) Interstitial pneumonitis related to rituximab therapy. N Engl J Med 348:2690–2691PubMedCrossRef

Macartney C, Burke E, Elborn S, Magee N, Noone P, Gleadhill I et al (2005) Bronchiolitis obliterans organizing pneumonia in a patient with non-Hodgkin’s lymphoma following R-CHOP and pegylated filgrastim. Leuk Lymphoma 46:1523–1526PubMedCrossRef

Kim KM, Kim HC, Jeon KN, Kim HG, Kang JH, Hahm JR et al (2008) Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma. Yonsei Med J 49:155–158PubMedCrossRef

Ram R, Ben-Bassat I, Shpilberg O, Polliack A, Raanani P (2009) The late adverse events of rituximab therapy—rare but there! Leuk Lymphoma 50:1083–1095PubMedCrossRef

DeMonaco NA, McCarty KS Jr, Joyce J, Jacobs SA (2007) Focal radiation fibrosis after radioimmunotherapy for follicular non-Hodgkin lymphoma. Clin Lymphoma Myeloma 7:369–372PubMedCrossRef

10.

Salem R, Parikh P, Atassi B, Lewandowski RJ, Ryu RK, Sato KT et al (2008) Incidence of radiation pneumonitis after hepatic intra-arterial radiotherapy with yttrium-90 microspheres assuming uniform lung distribution. Am J Clin Oncol 31:431–438PubMedCrossRef

11.

Ho S, Lau WY, Leung TW, Chan M, Johnson PJ, Li AK (1997) Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer. Eur J Nucl Med 24:293–298PubMed

12.

Slauson DO, Hahn FF, Benjamin SA, Chiffelle TL, Jones RK (1976) Inflammatory sequences in acute pulmonary radiation injury. Am J Pathol 82:549–572PubMed

13.

Leung TW, Lau WY, Ho SK, Ward SC, Chow JH, Chan MS et al (1995) Radiation pneumonitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys 33:919–924PubMedCrossRef

14.

Peerzada MM, Spiro TP, Daw HA (2010) Pulmonary toxicities of biologics: a review. Anticancer Drugs 21:131–139PubMedCrossRef

15.

Demedts M, Costabel U (2002) ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Eur Respir J 19:794–796PubMedCrossRef

16.

Hubbard R, Venn A, Smith C, Cooper M, Johnston I, Britton J (1998) Exposure to commonly prescribed drugs and the etiology of cryptogenic fibrosing alveolitis: a case—control study. Am J Respir Crit Care Med 157:743–747PubMed

17.

Scott J, Johnston I, Britton J (1990) What causes cryptogenic fibrosing alveolitis? A case—control study of environmental exposure to dust. Br Med J 301:1015–1017CrossRef

18.

Hubbard R, Lewis S, Richards K, Johnston I, Britton J (1996) Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis. Lancet 347:284–289PubMedCrossRef

19.

Camus P, Kudoh S, Ebina M (2004) Interstitial lung disease associated with drug therapy. Br J Cancer 91:S18–S23PubMedCrossRef

20.

Merad M, Le Cesne A, Baldeyrou P, Mesurolle B, Le Chevalier T (1997) Docetaxel and interstitial pulmonary injury. Ann Oncol 8:191–194PubMedCrossRef

Titel: Fatal interstitial pneumonitis in a patient with relapsed diffuse large B cell lymphoma following yttrium-90 ibritumomab tiuxetan
verfasst von: Moon Jin Kim
Gyeong-Won Lee
Jong Woo Seo
Hyun-Jung Kim
Sung-Nam Lim
Cheolwon Suh
Publikationsdatum: 01.10.2011
Verlag: Springer US
Erschienen in: Investigational New Drugs / Ausgabe 5/2011
Print ISSN: 0167-6997
Elektronische ISSN: 1573-0646
DOI: https://doi.org/10.1007/s10637-010-9460-0

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Fatal interstitial pneumonitis in a patient with relapsed diffuse large B cell lymphoma following yttrium-90 ibritumomab tiuxetan

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Summary

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