Skip to main content
Erschienen in: Journal of Neural Transmission 4/2013

01.04.2013 | Neurology and Preclinical Neurological Studies - Review Article

Fatigue assessment of Parkinson’s disease patient in clinic: specific versus holistic

verfasst von: Cristian Falup-Pecurariu

Erschienen in: Journal of Neural Transmission | Ausgabe 4/2013

Einloggen, um Zugang zu erhalten

Abstract

Fatigue is a frequently encountered non-motor symptom in Parkinson’s disease (PD). Being a subjective definition, with no biological markers, it is difficult to describe. Its definition is influenced by the background and culture of the patient. Subtypes of fatigue are peripheral fatigue and mental fatigue. The co-existence of other non-motor symptoms in PD complicates its assessment. Fatigue could be present before, at the time of diagnosis of PD in untreated patients or during the course of the disease. Scales that can be used for evaluation include generic one for a holistic manner and those specifically designed for PD. A scale designed for fatigue should differentiate between PD patients with fatigue and those without fatigue. The next step is to choose between unidimensional which evaluate one dimension and multidimensional scales. We present the main scales which can be used for fatigue assessment and their properties. The scales are presented with some psychometric properties in non-PD population and those properties through validation in PD population. Scales have some properties which could be recommended for screening and/or rating of severity of fatigue in PD.
Literatur
Zurück zum Zitat Abe K, Takanashi M, Yanagihara T (2000) Fatigue in patients with Parkinson’s disease. Behav Neurol 12(3):103–106PubMed Abe K, Takanashi M, Yanagihara T (2000) Fatigue in patients with Parkinson’s disease. Behav Neurol 12(3):103–106PubMed
Zurück zum Zitat Alves G (2012) Fatigue rating scales in Parkinson’s disease. In: Sampaio C, Goetz CG, Schrag A (eds) Rating scales in Parkinson’s disease, Clinical practice and research. Oxford University Press, New York, pp 233–259 Alves G (2012) Fatigue rating scales in Parkinson’s disease. In: Sampaio C, Goetz CG, Schrag A (eds) Rating scales in Parkinson’s disease, Clinical practice and research. Oxford University Press, New York, pp 233–259
Zurück zum Zitat Alves G, Wentzel-Larsen T, Larsen JP (2004) Is fatigue an independent and persistent symptom in patients with Parkinson disease? Neurology 63(10):1908–1911PubMedCrossRef Alves G, Wentzel-Larsen T, Larsen JP (2004) Is fatigue an independent and persistent symptom in patients with Parkinson disease? Neurology 63(10):1908–1911PubMedCrossRef
Zurück zum Zitat American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (2000) Fourth Edition, Text Revision, Washington, DC, American Psychiatric Association American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (2000) Fourth Edition, Text Revision, Washington, DC, American Psychiatric Association
Zurück zum Zitat Brown RG, Dittner A, Findley L, Wessely SC (2005) The Parkinson fatigue scale. Parkinsonism Relat Disord 11(1):49–55PubMedCrossRef Brown RG, Dittner A, Findley L, Wessely SC (2005) The Parkinson fatigue scale. Parkinsonism Relat Disord 11(1):49–55PubMedCrossRef
Zurück zum Zitat Bryant MS, Rintala DH, Hou JG, Rivas SP, Fernandez AL, Lai EC, Protas EJ (2012) The relation of falls to fatigue, depression and daytime sleepiness in Parkinson’s disease. Eur Neurol 67(6):326–330PubMedCrossRef Bryant MS, Rintala DH, Hou JG, Rivas SP, Fernandez AL, Lai EC, Protas EJ (2012) The relation of falls to fatigue, depression and daytime sleepiness in Parkinson’s disease. Eur Neurol 67(6):326–330PubMedCrossRef
Zurück zum Zitat Buchwald D, Pearlman T, Kith P, Schmaling K (1994) Gender differences in patients with chronic fatigue syndrome. J Gen Intern Med 9(7):397–401PubMedCrossRef Buchwald D, Pearlman T, Kith P, Schmaling K (1994) Gender differences in patients with chronic fatigue syndrome. J Gen Intern Med 9(7):397–401PubMedCrossRef
Zurück zum Zitat Chadhuri A, Behan PO (2000) Fatigue and basal ganglia. J Neurol Sci 179(S 1–2):34–42 Chadhuri A, Behan PO (2000) Fatigue and basal ganglia. J Neurol Sci 179(S 1–2):34–42
Zurück zum Zitat Chaudhuri KR, Healy DG, Schapira AH (2006a) Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol 5(3):235–245PubMedCrossRef Chaudhuri KR, Healy DG, Schapira AH (2006a) Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol 5(3):235–245PubMedCrossRef
Zurück zum Zitat Chaudhuri KR, Martinez-Martin P, Schapira AH et al (2006b) International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord 21(7):916–923PubMedCrossRef Chaudhuri KR, Martinez-Martin P, Schapira AH et al (2006b) International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord 21(7):916–923PubMedCrossRef
Zurück zum Zitat Chaudhuri KR, Martinez-Martin P, Brown RG et al (2007) The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: results from an international pilot study. Mov Disord 22(13):1901–1911PubMedCrossRef Chaudhuri KR, Martinez-Martin P, Brown RG et al (2007) The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: results from an international pilot study. Mov Disord 22(13):1901–1911PubMedCrossRef
Zurück zum Zitat David A, Pelosi A, McDonald E, Stephens D, Ledger D, Rathbone R, Mann A (1990) Tired, weak, or in need of rest: fatigue among general practice attenders. BMJ 301(6762):1199–1202PubMedCrossRef David A, Pelosi A, McDonald E, Stephens D, Ledger D, Rathbone R, Mann A (1990) Tired, weak, or in need of rest: fatigue among general practice attenders. BMJ 301(6762):1199–1202PubMedCrossRef
Zurück zum Zitat Dittner AJ, Wessely SC, Brown RG (2004) The assessment of fatigue. A practical guide for clinicians and researchers. J Psychosom Res 56(2):157–170PubMedCrossRef Dittner AJ, Wessely SC, Brown RG (2004) The assessment of fatigue. A practical guide for clinicians and researchers. J Psychosom Res 56(2):157–170PubMedCrossRef
Zurück zum Zitat Elbers R, van Wegen EE, Rochester L, Hetherington V, Nieuwboer A, Willems AM, Jones D, Kwakkel G (2009) Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson’s disease? Mov Disord 24(10):1512–1518PubMedCrossRef Elbers R, van Wegen EE, Rochester L, Hetherington V, Nieuwboer A, Willems AM, Jones D, Kwakkel G (2009) Is impact of fatigue an independent factor associated with physical activity in patients with idiopathic Parkinson’s disease? Mov Disord 24(10):1512–1518PubMedCrossRef
Zurück zum Zitat Fisk JD, Doble SE (2002) Construction and validation of a fatigue impact scale for daily administration (D-FIS). Qual Life Res 11(3):263–272PubMedCrossRef Fisk JD, Doble SE (2002) Construction and validation of a fatigue impact scale for daily administration (D-FIS). Qual Life Res 11(3):263–272PubMedCrossRef
Zurück zum Zitat Friedman JH, Friedman H (2001) Fatigue in Parkinson’s disease: a nine-year follow-up. Mov Disord 16(6):1120–1122PubMedCrossRef Friedman JH, Friedman H (2001) Fatigue in Parkinson’s disease: a nine-year follow-up. Mov Disord 16(6):1120–1122PubMedCrossRef
Zurück zum Zitat Friedman JH, Brown RG, Comella C, Garber CE, Krupp LB, Lou JS, Marsh L, Nail L, Shulman L, Taylor CB, as the Working Group on Fatigue in Parkinson’s Disease (2007) Fatigue in Parkinson’s disease. Mov Disord 22(3):297–308CrossRef Friedman JH, Brown RG, Comella C, Garber CE, Krupp LB, Lou JS, Marsh L, Nail L, Shulman L, Taylor CB, as the Working Group on Fatigue in Parkinson’s Disease (2007) Fatigue in Parkinson’s disease. Mov Disord 22(3):297–308CrossRef
Zurück zum Zitat Friedman JH, Alves G, Hagell P, Marinus J, Marsh L, Martinez-Martin P, Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins G, Schrag A (2010) Fatigue rating scales critique and recommendations by the movement disorders society task force on rating scales for Parkinson’s disease. Mov Disord 25(7):805–822PubMedCrossRef Friedman JH, Alves G, Hagell P, Marinus J, Marsh L, Martinez-Martin P, Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins G, Schrag A (2010) Fatigue rating scales critique and recommendations by the movement disorders society task force on rating scales for Parkinson’s disease. Mov Disord 25(7):805–822PubMedCrossRef
Zurück zum Zitat Garber CE, Friedman JH (2005) Fatigue. In: Pfeiffer RF, Wollner IB (eds) Parkinson’s disease and nonmotor dysfunction. Humana Press, New York, pp 281–294CrossRef Garber CE, Friedman JH (2005) Fatigue. In: Pfeiffer RF, Wollner IB (eds) Parkinson’s disease and nonmotor dysfunction. Humana Press, New York, pp 281–294CrossRef
Zurück zum Zitat Grace J, Mendelsohn A, Friedman JH (2007) A comparison of fatigue measures in Parkinson’s disease. Parkinsonism Relat Disord 13(7):443–445PubMedCrossRef Grace J, Mendelsohn A, Friedman JH (2007) A comparison of fatigue measures in Parkinson’s disease. Parkinsonism Relat Disord 13(7):443–445PubMedCrossRef
Zurück zum Zitat Hagell P, Höglund A, Reimer J, Eriksson B, Knutsson I, Widner H, Cella D (2006) Measuring fatigue in Parkinson’s disease: a psychometric study of two brief generic fatigue questionnaires. J Pain Symptom Manage 32(5):420–432PubMedCrossRef Hagell P, Höglund A, Reimer J, Eriksson B, Knutsson I, Widner H, Cella D (2006) Measuring fatigue in Parkinson’s disease: a psychometric study of two brief generic fatigue questionnaires. J Pain Symptom Manage 32(5):420–432PubMedCrossRef
Zurück zum Zitat Hagell P, Brundin L (2009) Towards an understanding of fatigue in Parkinson disease. J Neurol Neurosurg Psychiatry 80(5):489–492PubMedCrossRef Hagell P, Brundin L (2009) Towards an understanding of fatigue in Parkinson disease. J Neurol Neurosurg Psychiatry 80(5):489–492PubMedCrossRef
Zurück zum Zitat Hagell P, Rosblom T, Pålhagen S (2012) A Swedish version of the 16-item Parkinson fatigue scale (PFS-16). Acta Neurol Scand 125(4):288–292 Hagell P, Rosblom T, Pålhagen S (2012) A Swedish version of the 16-item Parkinson fatigue scale (PFS-16). Acta Neurol Scand 125(4):288–292
Zurück zum Zitat Havlikova E, Rosenberger J, Nagyova I, Middel B, Dubayova T, Gdovinova Z, van Dijk JP, Groothoff JW (2008) Impact of fatigue on quality of life in patients with Parkinson’s disease. Eur J Neurol 15(5):475–480PubMedCrossRef Havlikova E, Rosenberger J, Nagyova I, Middel B, Dubayova T, Gdovinova Z, van Dijk JP, Groothoff JW (2008) Impact of fatigue on quality of life in patients with Parkinson’s disease. Eur J Neurol 15(5):475–480PubMedCrossRef
Zurück zum Zitat Herlofson K, Larsen JP (2003) The influence of fatigue on health-related quality of life in patients with Parkinson’s disease. Acta Neurol Scand 107(1):1–6PubMedCrossRef Herlofson K, Larsen JP (2003) The influence of fatigue on health-related quality of life in patients with Parkinson’s disease. Acta Neurol Scand 107(1):1–6PubMedCrossRef
Zurück zum Zitat Hjollund NH, Andersen JH, Bech P (2007) Assessment of fatigue in chronic disease: a bibliographic study of fatigue measurement scales. Health Qual Life Outcomes 5:12PubMedCrossRef Hjollund NH, Andersen JH, Bech P (2007) Assessment of fatigue in chronic disease: a bibliographic study of fatigue measurement scales. Health Qual Life Outcomes 5:12PubMedCrossRef
Zurück zum Zitat Hossain JL, Ahmad P, Reinish LW, Kayumov L, Hossain NK, Shapiro CM (2005) Subjective fatigue and subjective sleepiness: two independent consequences of sleep disorders? J Sleep Res 14:245–253PubMedCrossRef Hossain JL, Ahmad P, Reinish LW, Kayumov L, Hossain NK, Shapiro CM (2005) Subjective fatigue and subjective sleepiness: two independent consequences of sleep disorders? J Sleep Res 14:245–253PubMedCrossRef
Zurück zum Zitat Kluger BM, Friedman JH (2009) Fatigue in Parkinson’s disease. In: Chaudhuri KR, Tolosa E, Schapira A, Poewe W (eds) Non-motor symptoms of Parkinson’s disease. Oxford University Press, New York, pp 107–120 Kluger BM, Friedman JH (2009) Fatigue in Parkinson’s disease. In: Chaudhuri KR, Tolosa E, Schapira A, Poewe W (eds) Non-motor symptoms of Parkinson’s disease. Oxford University Press, New York, pp 107–120
Zurück zum Zitat Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46:1121–1123PubMedCrossRef Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46:1121–1123PubMedCrossRef
Zurück zum Zitat Kummer A, Scalzo P, Cardoso F, Teixeira AL (2011) Evaluation of fatigue in Parkinson's disease using the Brazilian version of Parkinson's Fatigue Scale. Acta Neurol Scand 123(2):130–136 Kummer A, Scalzo P, Cardoso F, Teixeira AL (2011) Evaluation of fatigue in Parkinson's disease using the Brazilian version of Parkinson's Fatigue Scale. Acta Neurol Scand 123(2):130–136
Zurück zum Zitat Lou JS, Kearns G, Oken B, Sexton G, Nutt J (2001) Exacerbated physical fatigue and mental fatigue in Parkinson’s disease. Mov Disord 16(2):190–196PubMedCrossRef Lou JS, Kearns G, Oken B, Sexton G, Nutt J (2001) Exacerbated physical fatigue and mental fatigue in Parkinson’s disease. Mov Disord 16(2):190–196PubMedCrossRef
Zurück zum Zitat Martinez-Martin P, Catalan MJ, Benito-Leon J, Moreno AO, Zamarbide I, Cubo E, van Blercon N, Arillo VC, Pondal M, Linazasoro G, Alonso F, Ruiz PG, Frades B (2006) Impact of fatigue in Parkinson’s disease: the fatigue impact scale for daily use (D-FIS). Qual Life Res 15(4):597–606PubMedCrossRef Martinez-Martin P, Catalan MJ, Benito-Leon J, Moreno AO, Zamarbide I, Cubo E, van Blercon N, Arillo VC, Pondal M, Linazasoro G, Alonso F, Ruiz PG, Frades B (2006) Impact of fatigue in Parkinson’s disease: the fatigue impact scale for daily use (D-FIS). Qual Life Res 15(4):597–606PubMedCrossRef
Zurück zum Zitat Martinez-Martin P, Rodriguez-Blazquez C, Abe K, Bhattacharyya KB, Bloem BR, Carod-Artal FJ, Prakash R, Esselink RA, Falup-Pecurariu C, Gallardo M, Mir P, Naidu Y, Nicoletti A, Sethi K, Tsuboi Y, van Hilten JJ, Visser M, Zappia M, Chaudhuri KR (2009) International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology 73(19):1584–1591PubMedCrossRef Martinez-Martin P, Rodriguez-Blazquez C, Abe K, Bhattacharyya KB, Bloem BR, Carod-Artal FJ, Prakash R, Esselink RA, Falup-Pecurariu C, Gallardo M, Mir P, Naidu Y, Nicoletti A, Sethi K, Tsuboi Y, van Hilten JJ, Visser M, Zappia M, Chaudhuri KR (2009) International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology 73(19):1584–1591PubMedCrossRef
Zurück zum Zitat Mizuno K, Tanaka M, Nozaki S, Yamaguti K, Mizuma H, Sasabe T, Sugino T, Shirai T, Kataoka Y, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y (2007) Mental fatigue-induced decrease in levels of several plasma amino acids. J Neural Transm 114(5):555–561PubMedCrossRef Mizuno K, Tanaka M, Nozaki S, Yamaguti K, Mizuma H, Sasabe T, Sugino T, Shirai T, Kataoka Y, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y (2007) Mental fatigue-induced decrease in levels of several plasma amino acids. J Neural Transm 114(5):555–561PubMedCrossRef
Zurück zum Zitat Pavese N, Metta V, Bose SK, Chaudhuri KR, Brooks DJ (2010) Fatigue in Parkinson’s disease is linked to striatal and limbic serotonergic dysfunction. Brain 133(11):3434–3443PubMedCrossRef Pavese N, Metta V, Bose SK, Chaudhuri KR, Brooks DJ (2010) Fatigue in Parkinson’s disease is linked to striatal and limbic serotonergic dysfunction. Brain 133(11):3434–3443PubMedCrossRef
Zurück zum Zitat Pawlikowska T, Chalder T, Hirsch SR, Wallace P, Wight DJ, Wessely SC (1994) Population based study of fatigue and psychosocial distress. BMJ 308(6931):736–763CrossRef Pawlikowska T, Chalder T, Hirsch SR, Wallace P, Wight DJ, Wessely SC (1994) Population based study of fatigue and psychosocial distress. BMJ 308(6931):736–763CrossRef
Zurück zum Zitat Rascol O, Fitzer-Attas CJ, Hauser R, Jankovic J, Lang A, Langston JW, Melamed E, Poewe W, Stocchi F, Tolosa E, Eyal E, Weiss YM, Olanow CW (2011) A double-blind, delayed-start trial of rasagiline in Parkinson’s disease (the ADAGIO study): pre-specified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes. Lancet Neurol 10(5):415–423PubMedCrossRef Rascol O, Fitzer-Attas CJ, Hauser R, Jankovic J, Lang A, Langston JW, Melamed E, Poewe W, Stocchi F, Tolosa E, Eyal E, Weiss YM, Olanow CW (2011) A double-blind, delayed-start trial of rasagiline in Parkinson’s disease (the ADAGIO study): pre-specified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes. Lancet Neurol 10(5):415–423PubMedCrossRef
Zurück zum Zitat Risdale L, Evans A, Jerrett W, Mandalia S, Osler K, Vora H (1993) Patients with fatigue in general practice: a prospective study. BMJ 307(6896):103–106CrossRef Risdale L, Evans A, Jerrett W, Mandalia S, Osler K, Vora H (1993) Patients with fatigue in general practice: a prospective study. BMJ 307(6896):103–106CrossRef
Zurück zum Zitat Schifitto G, Friedman JH, Oakes D, Shulman L, Comella CL, Marek K, Fahn S, Parkinson Study Group ELLDOPA Investigators (2008) Fatigue in levodopa-naive subjects with Parkinson disease. Neurology 71(7):481–485CrossRef Schifitto G, Friedman JH, Oakes D, Shulman L, Comella CL, Marek K, Fahn S, Parkinson Study Group ELLDOPA Investigators (2008) Fatigue in levodopa-naive subjects with Parkinson disease. Neurology 71(7):481–485CrossRef
Zurück zum Zitat Schwartz JE, Jandorf L, Krupp LB (1993) The measurement of fatigue: a new instrument. J Psychosom Res 37(7):753–762PubMedCrossRef Schwartz JE, Jandorf L, Krupp LB (1993) The measurement of fatigue: a new instrument. J Psychosom Res 37(7):753–762PubMedCrossRef
Zurück zum Zitat Smets EMA, Garseen B, Bonke B, Dehaes JCJM (1995) The multidimensional fatigue inventory (MFI). Psychometric properties of an instrument to assess fatigue. J Psychosom Res 39:315–325PubMedCrossRef Smets EMA, Garseen B, Bonke B, Dehaes JCJM (1995) The multidimensional fatigue inventory (MFI). Psychometric properties of an instrument to assess fatigue. J Psychosom Res 39:315–325PubMedCrossRef
Zurück zum Zitat Taylor RR, Jasonn LA, Torres A (2000) Fatigue rating scales: an empirical comparison. Psychol Med 30:849–856PubMedCrossRef Taylor RR, Jasonn LA, Torres A (2000) Fatigue rating scales: an empirical comparison. Psychol Med 30:849–856PubMedCrossRef
Zurück zum Zitat van Hilten JJ, Weggeman M, van der Velde EA, Kerkhof GA, van Dijk JG, Roos RA (1993a) Sleep, excessive daytime sleepiness and fatigue in Parkinson’s disease. J Neural Transm Park Dis Dement Sect 5(3):235–244PubMedCrossRef van Hilten JJ, Weggeman M, van der Velde EA, Kerkhof GA, van Dijk JG, Roos RA (1993a) Sleep, excessive daytime sleepiness and fatigue in Parkinson’s disease. J Neural Transm Park Dis Dement Sect 5(3):235–244PubMedCrossRef
Zurück zum Zitat van Hilten JJ, Hoogland G, van der Velde EA, Middelkoop HA, Kerkhof GA, Roos RA (1993b) Diurnal effects of motor activity and fatigue in Parkinson’s disease. J Neurol Neurosurg Psychiatry 56(8):847–874 van Hilten JJ, Hoogland G, van der Velde EA, Middelkoop HA, Kerkhof GA, Roos RA (1993b) Diurnal effects of motor activity and fatigue in Parkinson’s disease. J Neurol Neurosurg Psychiatry 56(8):847–874
Zurück zum Zitat Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E (1997) Measuring fatigue and other anemia-related symptoms with the functional assessment of cancer therapy (FACT) measurement system. J Pain Symptom Manage 13(2):63–74PubMedCrossRef Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E (1997) Measuring fatigue and other anemia-related symptoms with the functional assessment of cancer therapy (FACT) measurement system. J Pain Symptom Manage 13(2):63–74PubMedCrossRef
Metadaten
Titel
Fatigue assessment of Parkinson’s disease patient in clinic: specific versus holistic
verfasst von
Cristian Falup-Pecurariu
Publikationsdatum
01.04.2013
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 4/2013
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-013-0969-1

Weitere Artikel der Ausgabe 4/2013

Journal of Neural Transmission 4/2013 Zur Ausgabe

Neurology and Preclinical Neurological Studies - Review Article

Treatment of Parkinson’s disease in the advanced stage

Neurology and Preclinical Neurological Studies - Review Article

The pharmacology of Tourette syndrome

Neurology and Preclinical Neurological Studies - Review Article

Instruments for holistic assessment of Parkinson’s disease

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Nicht Creutzfeldt Jakob, sondern Abführtee-Vergiftung

29.05.2024 Hyponatriämie Nachrichten

Eine ältere Frau trinkt regelmäßig Sennesblättertee gegen ihre Verstopfung. Der scheint plötzlich gut zu wirken. Auf Durchfall und Erbrechen folgt allerdings eine Hyponatriämie. Nach deren Korrektur kommt es plötzlich zu progredienten Kognitions- und Verhaltensstörungen.

Schutz der Synapsen bei Alzheimer

29.05.2024 Morbus Alzheimer Nachrichten

Mit einem Neurotrophin-Rezeptor-Modulator lässt sich möglicherweise eine bestehende Alzheimerdemenz etwas abschwächen: Erste Phase-2-Daten deuten auf einen verbesserten Synapsenschutz.

Sozialer Aufstieg verringert Demenzgefahr

24.05.2024 Demenz Nachrichten

Ein hohes soziales Niveau ist mit die beste Versicherung gegen eine Demenz. Noch geringer ist das Demenzrisiko für Menschen, die sozial aufsteigen: Sie gewinnen fast zwei demenzfreie Lebensjahre. Umgekehrt steigt die Demenzgefahr beim sozialen Abstieg.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.