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Current Atherosclerosis Reports

Erschienen in:

01.12.2021 | Genetics and Genomics (A. Marian, Section Editor)

Gene-Environment Interactions for Cardiovascular Disease

verfasst von: Jaana A. Hartiala, James R. Hilser, Subarna Biswas, Aldons J. Lusis, Hooman Allayee

Erschienen in: Current Atherosclerosis Reports | Ausgabe 12/2021

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Abstract

Purpose of Review

We provide an overview of recent findings with respect to gene-environment (GxE) interactions for cardiovascular disease (CVD) risk and discuss future opportunities for advancing the field.

Recent Findings.

Over the last several years, GxE interactions for CVD have mostly been identified for smoking and coronary artery disease (CAD) or related risk factors. By comparison, there is more limited evidence for GxE interactions between CVD outcomes and other exposures, such as physical activity, air pollution, diet, and sex. The establishment of large consortia and population-based cohorts, in combination with new computational tools and mouse genetics platforms, can potentially overcome some of the limitations that have hindered human GxE interaction studies and reveal additional association signals for CVD-related traits.

Summary

The identification of novel GxE interactions is likely to provide a better understanding of the pathogenesis and genetic liability of CVD, with significant implications for healthy lifestyles and therapeutic strategies.

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Titel: Gene-Environment Interactions for Cardiovascular Disease
verfasst von: Jaana A. Hartiala
James R. Hilser
Subarna Biswas
Aldons J. Lusis
Hooman Allayee
Publikationsdatum: 01.12.2021
Verlag: Springer US
Erschienen in: Current Atherosclerosis Reports / Ausgabe 12/2021
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-021-00974-9

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Gene-Environment Interactions for Cardiovascular Disease