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European Archives of Psychiatry and Clinical Neuroscience
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 4/2015

01.06.2015 | Original Paper

Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity

verfasst von: Thomas Nickl-Jockschat, Tony Stöcker, Axel Krug, Valentin Markov, Ivan I. Maximov, Ruiwang Huang, Frank Schneider, Ute Habel, Simon B. Eickhoff, Klaus Zerres, Markus M. Nöthen, Marcella Rietschel, N. Jon Shah, Jens Treutlein, Tilo Kircher

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 4/2015

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Abstract

G72 (syn. DAOA, d-amino acid oxidase activator) is a susceptibility gene for both schizophrenia and bipolar disorder. Diffusion tensor imaging studies hint at changes in fiber tract integrity in both disorders. We aimed to investigate whether a G72 susceptibility haplotype causes changes in fiber tract integrity in young healthy subjects. We compared fractional anisotropy in 47 subjects that were either homozygous for the M23/M24 risk haplotype (n = 20) or homozygous for M23(rs3918342)/M24(rs1421292) wild type (n = 27) using diffusion tensor imaging with 3 T. Tract-based spatial statistics, a method especially developed for diffusion data analysis, was used to delineate the major fiber tracts. We found clusters of increased FA values in homozygous risk haplotype carriers in the right periinsular region and in the right inferior parietal lobe (IPL). We did not find clusters indicating decreased FA values. The insula and the IPL have been implicated in both schizophrenia and bipolar pathophysiology. Increased FA values might reflect changes in dendritic morphology as previously described by in vitro studies. These findings further corroborate the hypothesis that a shared gene pool between schizophrenia and bipolar disorder might lead to neuroanatomic changes that confer an unspecific vulnerability for both disorders.
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Metadaten
Titel
Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity
verfasst von
Thomas Nickl-Jockschat
Tony Stöcker
Axel Krug
Valentin Markov
Ivan I. Maximov
Ruiwang Huang
Frank Schneider
Ute Habel
Simon B. Eickhoff
Klaus Zerres
Markus M. Nöthen
Marcella Rietschel
N. Jon Shah
Jens Treutlein
Tilo Kircher
Publikationsdatum
01.06.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 4/2015
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-014-0516-6

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