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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 3/2014

01.09.2014 | Skeletal Genetics (ML Johnson and S Ralston, Section Editors)

Genetics of Paget’s Disease of Bone

verfasst von: Stuart H. Ralston, Omar M. E. Albagha

Erschienen in: Current Osteoporosis Reports | Ausgabe 3/2014

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Abstract

Paget’s disease of bone (PDB) is a common condition, which is characterised by focal areas of increased and disorganized bone remodeling. Genetic factors play an important role in the disease. In some cases, Paget’s disease is inherited in an autosomal dominant manner and the most common cause for this is a mutation in the SQSTM1 gene. Other familial cases have been linked to the OPTN locus on Chromosome 10p13 and still other variants have been identified by genome wide association studies that lie within or close to genes that play roles in osteoclast differentiation and function. Mutations in TNFRSF11A, TNFRSF11B and VCP have been identified in rare syndromes with PDB-like features. These advances have improved understanding of bone biology and the causes of PDB. The identification of genetic markers for PDB also raises the prospect that genetic profiling could identify patients at high risk of developing complications, permitting enhanced surveillance and early therapeutic intervention.
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Metadaten
Titel
Genetics of Paget’s Disease of Bone
verfasst von
Stuart H. Ralston
Omar M. E. Albagha
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 3/2014
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-014-0219-y

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