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01.05.2015 | e-Herz: Original article

Genetic association of IL-21 polymorphisms with dilated cardiomyopathy in a Han Chinese population

verfasst von: J. Lin, Y. Peng, B. Zhou, Q. Dou, Y. Li, H. Yang, L. Zhang, L. Rao

Erschienen in: Herz | Ausgabe 3/2015

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Abstract

Background

Autoimmune abnormalities appear to be major predisposing factors for dilated cardiomyopathy (DCM). Interleukin-21 (IL-21) gene polymorphisms have been previously found to be associated with autoimmune diseases. This study aimed to assess the role of IL-21 in DCM in a Han Chinese population.

Patients and methods

A total of 364 independent DCM patients and 384 unrelated healthy controls were recruited for this case–control association study. rs2055979 and rs12508721 were genotyped by PCR-RFLP. IL-21 plasma levels in samples from DCM and control individuals were evaluated by ELISA. The association between the SNPs and overall survival (OS) was evaluated by Kaplan–Meier analysis. Hazard ratios and 95 % confidence intervals (CIs) were assessed in a Cox regression analysis with adjustment for sex and age.

Results

The T allele frequencies of both SNPs were higher in DCM patients than in controls (p < 0.001). The genotypic frequencies of rs2055979 G > T and rs12508721 C > T were associated with DCM in the codominant, dominant, and recessive models (p < 0.05). IL-21 plasma levels in patients were higher than those of the control subjects (p = 0.009). The TT genotypes of both SNPs were associated with significantly higher plasma levels (p_rs2055979 = 0.03, p_rs12508721 < 0.001). Kaplan–Meier analysis showed that the genotypic frequencies of both SNPs were associated with OS in the dominant and the recessive models (p < 0.001). The TT genotypes of both SNPs were associated with the worst OS (p < 0.001).

Conclusion

Our findings suggest that theIL-21 gene plays an important role in susceptibility to DCM as well as in the clinical outcome of this ailment in the Han Chinese population.

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Titel: Genetic association of IL-21 polymorphisms with dilated cardiomyopathy in a Han Chinese population
verfasst von: J. Lin
Y. Peng
B. Zhou
Q. Dou
Y. Li
H. Yang
L. Zhang
L. Rao
Publikationsdatum: 01.05.2015
Verlag: Urban & Vogel
Erschienen in: Herz / Ausgabe 3/2015
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-013-4039-0

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Abstract

Background

Patients and methods

Results

Conclusion

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