Erschienen in:
01.01.2010 | Drug Reactions and Interactions
Glitazones accelerate bone loss and increase the risk of fracture in patients with type 2 diabetes mellitus
Erschienen in:
Drugs & Therapy Perspectives
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Ausgabe 1/2010
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Excerpt
Thiazolidinediones, which are commonly known as glitazones, are used in the treatment of type 2 diabetes mellitus. Through their activation of peroxisome proliferator-activated receptor-γ nuclear transcription factor, glitazones may decrease bone formation, leading to decreased bone mineral density and an increased risk of fractures, particularly in women. Currently, there are no data on whether any treatments mitigate glitazone-induced adverse skeletal effects. …