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Journal of Endocrinological Investigation

Erschienen in:

20.09.2023 | Brief Report

Gut microbiota, a potential cause of higher insulin sensitivity in children with Prader–Willi syndrome

verfasst von: M.-L. Zhong, Y.-Q. Cai, Y.-F. Tang, Y.-L. Dai, Y.-H. Jiang, Y. Ni, C.-C. Zou

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 4/2024

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Abstract

Purpose

Obesity is the main driving factor for comorbidities in Prader–Willi syndrome (PWS) patients due to overeating behaviors. The gut microbiota has been implicated in the etiology of obesity and associated comorbidities. The purpose of the present study was to characterize the fecal microbiota in Chinese patients with PWS and compare it to that of patients with obesity as well as healthy controls.

Methods

We conducted a cross-sectional study with 35 PWS patients (PWS), 35 patients with obesity (OB), and 35 healthy controls (HC). Metagenomic sequencing was performed in stool samples.

Results

The composition of the fecal microbiota in PWS patients differed from that of participants in the OB and HC groups. It was characterized by increased Akkermansia Eubacterium, Eubacterium rectale, and Roseburia intestinalis and decreased Parabacteroides and Phascolarctobacterium. Additionally, the homeostatic model assessment of insulin resistance (HOMA-IR) was lower in PWS patients than in patients with obesity. Spearman rank correlation analysis showed that Achromobacter, Acidiphilium, Xylophilus, and Frisingicoccus were significantly negatively correlated with HOMA-IR.

Conclusion

The composition of the gut microbiota in Chinese PWS patients differed from that in patients with obesity, which might contribute to higher insulin sensitivity in PWS patients.

Nur mit Berechtigung zugänglich

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Titel: Gut microbiota, a potential cause of higher insulin sensitivity in children with Prader–Willi syndrome
verfasst von: M.-L. Zhong
Y.-Q. Cai
Y.-F. Tang
Y.-L. Dai
Y.-H. Jiang
Y. Ni
C.-C. Zou
Publikationsdatum: 20.09.2023
Verlag: Springer International Publishing
Erschienen in: Journal of Endocrinological Investigation / Ausgabe 4/2024
Elektronische ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-023-02194-1

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Gut microbiota, a potential cause of higher insulin sensitivity in children with Prader–Willi syndrome

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