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01.09.2015 | Original Contribution

High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol

verfasst von: Gokhan Sadi, Volkan Ergin, Guldal Yilmaz, M. Bilgehan Pektas, O. Gokhan Yildirim, Adnan Menevse, Fatma Akar

Erschienen in: European Journal of Nutrition | Ausgabe 6/2015

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Abstract

Purpose

The increased consumption of high-fructose corn syrup (HFCS) may contribute to the worldwide epidemic of fatty liver. In this study, we have investigated whether HFCS intake (20 % beverages) influences lipid synthesis and accumulation in conjunction with insulin receptor substrate-1/2 (IRS-1; IRS-2), endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1) and inducible NOS (iNOS) expressions in liver of rats. Resveratrol was tested for its potential efficacy on changes induced by HFCS.

Methods

Animals were randomly divided into four groups as control, resveratrol, HFCS and resveratrol plus HFCS (resveratrol + HFCS). HFCS was given as 20 % solutions in drinking water. Feeding of all rats was maintained by a standard diet that enriched with or without resveratrol for 12 weeks.

Results

Dietary HFCS increased triglyceride content and caused mild microvesicular steatosis in association with up-regulation of fatty acid synthase and sterol regulatory element binding protein (SREBP)-1c in liver of rats. Moreover, HFCS feeding impaired hepatic expression levels of IRS-1, eNOS and SIRT1 mRNA/proteins, but did not change iNOS level. Resveratrol promoted IRS, eNOS and SIRT1, whereas suppressed SREBP-1c expression in rats fed with HFCS.

Conclusions

Resveratrol supplementation considerably restored hepatic changes induced by HFCS. The improvement of hepatic insulin signaling and activation of SIRT1 by resveratrol may be associated with decreased triglyceride content and expression levels of the lipogenic genes of the liver.

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Titel: High-fructose corn syrup-induced hepatic dysfunction in rats: improving effect of resveratrol
verfasst von: Gokhan Sadi
Volkan Ergin
Guldal Yilmaz
M. Bilgehan Pektas
O. Gokhan Yildirim
Adnan Menevse
Fatma Akar
Publikationsdatum: 01.09.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 6/2015
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-014-0765-1

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