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European Archives of Oto-Rhino-Laryngology

Erschienen in:

04.10.2023 | Head and Neck

Impact of dysplasia at resection margin on oncologic outcome after curative resection of oral tongue squamous cell carcinoma: significance of high-grade dysplastic resection margin

verfasst von: Younghac Kim, Changhee Lee, Yujin Heo, Sung Ha Jung, Yung Jee Kang, Sung Yool Park, Man Ki Chung, Han-Sin Jeong, Young-Ik Son, Junhun Cho, Chung-Hwan Baek, Nayeon Choi

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 1/2024

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Abstract

Background

This study aimed to compare the oncologic outcomes among negative, close, positive, and dysplasia resection margins (RMs) with oral tongue squamous cell carcinoma (OSCC) and to investigate the impact of dysplastic RMs.

Methods

The 565 patients were retrospectively analyzed and divided into four groups according to RM. Dysplasia was classified into mild, moderate, and severe subgroups.

Results

RMs consisted of negative (62.1%), close (27.1%), positive (2.1%), and dysplastic (8.7%). In multivariate analysis, advanced T/N stages and positive RM were significant risk factors for overall survival, while dysplasia at the RM was not a significant risk factor for locoregional recurrence or overall survival. In subgroup analysis of patients with dysplastic margin, RM with severe dysplasia showed higher recurrence than mild and moderate dysplasia.

Conclusions

Dysplastic RM was not a risk factor for recurrence and survival. Severe dysplasia RM should be carefully observed due to higher recurrence compared to other dysplasia RMs.

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Titel: Impact of dysplasia at resection margin on oncologic outcome after curative resection of oral tongue squamous cell carcinoma: significance of high-grade dysplastic resection margin
verfasst von: Younghac Kim
Changhee Lee
Yujin Heo
Sung Ha Jung
Yung Jee Kang
Sung Yool Park
Man Ki Chung
Han-Sin Jeong
Young-Ik Son
Junhun Cho
Chung-Hwan Baek
Nayeon Choi
Publikationsdatum: 04.10.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 1/2024
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08233-0

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Impact of dysplasia at resection margin on oncologic outcome after curative resection of oral tongue squamous cell carcinoma: significance of high-grade dysplastic resection margin