Erschienen in:
01.04.2007 | Correspondence
In response to Isbister et al.: Application of pharmacokinetic–pharmacodynamic modeling in management of QT abnormalities after citalopram overdose
verfasst von:
Alex Manini, Silas Smith, Joshua Moskovitz, Lewis Nelson
Erschienen in:
Intensive Care Medicine
|
Ausgabe 4/2007
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Excerpt
Sir: We read with interest the recent article [
1] regarding derivation of a clinical algorithm for citalopram overdose and applaud the use of serum citalopram concentrations from the derivation cohort. While the performance of computer simulations to derive “at risk” clinical parameters is a potentially powerful approach, we have some hesitation about applying this particular algorithm to actual patients. …