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Pediatric Surgery International

Erschienen in:

01.11.2003 | Original Article

Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung’s disease

verfasst von: C. J. Newman, R. N. Laurini, Y. Lesbros, O. Reinberg, B. J. Meyrat

Erschienen in: Pediatric Surgery International | Ausgabe 9-10/2003

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Abstract

Surgery for Hirschsprung’s disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung’s disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung’s disease with that in normal colon. We correlated these results with the corresponding neural intestinal histology determined by CD56 and the protein gene product 9.5 immunohistochemistry. The distribution of ICC in the proximal segment of resected bowel is identical to that of normal colon, regardless of normal or abnormal colon innervation. ICC distribution does not seem to contribute to post-operative bowel motility disorders in patients operated for Hirschsprung’s disease

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Titel: Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung’s disease
verfasst von: C. J. Newman
R. N. Laurini
Y. Lesbros
O. Reinberg
B. J. Meyrat
Publikationsdatum: 01.11.2003
Verlag: Springer-Verlag
Erschienen in: Pediatric Surgery International / Ausgabe 9-10/2003
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-003-1026-1

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