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Journal of Neuro-Oncology

Erschienen in:

01.09.2010 | Invited Review

Intracranial meningiomas of atypical (WHO grade II) histology

verfasst von: Leland Rogers, Mark Gilbert, Michael A. Vogelbaum

Erschienen in: Journal of Neuro-Oncology | Ausgabe 3/2010

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Abstract

Atypical (WHO grade II) meningiomas occupy an intermediate risk group between benign (WHO grade I) and anaplastic (WHO grade III) meningiomas. Although grade II meningiomas have traditionally been recognized in only about 5% of cases, after changes in diagnostic criteria with the current 2007 WHO standards, they now comprise approximately 20–35% of all meningiomas. Given the magnitude of this change, much work is now needed to solidify the adoption of these standards, to render inter-observer and inter-institutional comparisons more uniform, and to more carefully define the incidence of grade II histology. However, it is clear that they carry a several-fold increased risk of recurrence, as well as an increased rate of mortality. We will discuss the definition, diagnosis, and treatment of patients with atypical meningioma; review the current phase II cooperative trials; and draw attention to some questions timely for pre-clinical and clinical research.

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Titel: Intracranial meningiomas of atypical (WHO grade II) histology
verfasst von: Leland Rogers
Mark Gilbert
Michael A. Vogelbaum
Publikationsdatum: 01.09.2010
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 3/2010
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-010-0343-1

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