Journal of Assisted Reproduction and Genetics OnlineFirst articles

Open Access 01.06.2024 | Reproductive physiology and disease

Chemical reversion of age-related oocyte dysfunction fails to enhance embryo development in a bovine model of postovulatory aging

Female age is the most important predictor of in vitro fertilization success [ 1 – 5 ] but there are no treatments available to overcome the oocyte competence decline associated with advanced maternal age (AMA). In addition to aneuploidy [ 6 ] …

verfasst von:: Ana Filipa Ferreira, Juliana Machado-Simões, Inês Moniz, Maria Soares, Alexandra Carvalho, Patrícia Diniz, João Ramalho-Santos, Ana Paula Sousa, Luís Lopes-da-Costa, Teresa Almeida-Santos

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31.05.2024 | Genetics

The relationship between Toll-like receptor-4 genes and preeclampsia outcomes

Preeclampsia (PE) is a serious disorder that has a significant impact on maternal and perinatal health, becoming one of the leading causes of morbidity and mortality during pregnancy. According to D. Miller et al. [ 1 ] and E. Dimitriadis et al. [ …

verfasst von:: Almagul Kurmanova, Gulfairuz Urazbayeva, Damilya Salimbayeva, Aigul Terlikbayeva, Zhanar Kypshakbayeva, Makhambet Smailov

31.05.2024 | Assisted Reproduction Technologies

Development of a machine learning–based prediction model for clinical pregnancy of intrauterine insemination in a large Chinese population

Intrauterine insemination (IUI) is a recommended first-line treatment for couples suffering from unexplained subfertility, with advantages of less invasiveness, fewer adverse effects, and lower complication rates [ 1 ]. However, the clinical …

verfasst von:: Jialin Wu, Tingting Li, Linan Xu, Lina Chen, Xiaoyan Liang, Aihua Lin, Wangjian Zhang, Rui Huang

Open Access 30.05.2024 | Gamete Biology

Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes

Oocyte maturation is a synchronized nuclear and cytoplasmic developmental process that results in the extrusion of the first polar body (PB1) and deposition of proteins, organelles, and transcripts needed for fertilization competence and …

verfasst von:: Bruna Paulsen, Sabrina Piechota, Ferran Barrachina, Alexa Giovannini, Simone Kats, Kathryn S. Potts, Graham Rockwell, Maria Marchante, Samantha L. Estevez, Alexander D. Noblett, Alexandra B. Figueroa, Caroline Aschenberger, Dawn A. Kelk, Marcy Forti, Shelby Marcinyshyn, Klaus Wiemer, Marta Sanchez, Pedro Belchin, Joseph A. Lee, Erkan Buyuk, Rick E. Slifkin, Merrick Pierson Smela, Patrick R. J. Fortuna, Pranam Chatterjee, David H. McCulloh, Alan B. Copperman, Daniel Ordonez-Perez, Joshua U. Klein, Christian C. Kramme

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29.05.2024 | Reproductive physiology and disease

Kisspeptin expression during menstruation in PCOS patients undergoing ovulation induction and the correlation with early pregnancy

Kisspeptins, a family of neuropeptides with arginine and phenylalanine at their C termini, serve as pivotal regulators of the mammalian reproductive axis, often known as the hypothalamic-pituitary-ovarian (HPO) in humans [ 1 ]. The KISS-receptor …

verfasst von:: Qiao Peng, Siting Lv, Yidi Wen, Lianlian Wang, Wenwu Gui

Open Access 29.05.2024 | Assisted Reproduction Technologies

The pregnancy outcomes among women receiving individualized algorithm dosing with follitropin delta: a systematic review of randomized controlled trials

The pioneering work on gonadotropins [ 1 , 2 ] corroborated with the joint applications in translational medicine [ 3 ] paved the way towards synthesizing novel recombinant human follicle-stimulating hormones (r-hFSHs) of high purity through …

verfasst von:: Bogdan Doroftei, Ovidiu-Dumitru Ilie, Ana-Maria Dabuleanu, Theodora Armeanu, Radu Maftei

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22.05.2024 | Gamete Biology

Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality

Due to the demands of modern lifestyles, couples often postpone their initial pregnancy, which may cause increased female infertility, with advanced female age and oocyte quality emerging as the predominant contributing factors. Other than …

verfasst von:: Sanath Udayanga Kankanam Gamage, Shu Hashimoto, Yuki Miyamoto, Tatsuya Nakano, Masaya Yamanaka, Hideki Kitaji, Yuki Takada, Hiroshi Matsumoto, Akiko Koike, Manabu Satoh, Masako Ichishi, Masatoshi Watanabe, Yoshiharu Morimoto

22.05.2024 | Genetics

Identification of a novel CFAP61 homozygous splicing variant associated with multiple morphological abnormalities of the flagella

In this study, we investigated the role of a newly identified homozygous variant (c.1245 + 6T > C) in the CFAP61 gene in the development of multiple morphologically abnormal flagella (MMAF) in an infertile patient. Using exome sequencing, we …

verfasst von:: Anne-Laure Barbotin, Angèle Boursier, Anne-Sophie Jourdain, Alexandre Moerman, Baptiste Rabat, Mariam Chehimi, Caroline Thuillier, Jamal Ghoumid, Thomas Smol

21.05.2024 | Assisted Reproduction Technologies

Exposure to the reproductive endocrinology subspecialty among obstetrics and gynecology residency programs

The increased prevalence of infertility, as well as the limited number of physicians trained in Reproductive Endocrinology and Infertility (REI), highlight the need for more physicians trained in Reproductive Endocrinology and Infertility (REI) [ 1 …]. Increased education, support, and counseling are necessary to facilitate optimal care for couples struggling to conceive. Obstetrics and gynecology (Ob-gyn) residency aims to train residents and equip them with comprehensive knowledge to prepare for general practice or future subspecialty training. The Accredited Counsel for Graduate Medical Education (ACGME) program requirements for Graduate Medical Education (GME) and Ob-gyn do not require clinical exposure to Reproductive Endocrinology and Infertility (REI) [

verfasst von:: Rebecca Zeidman, Eve C. Feinberg, MaryEllen Pavone

21.05.2024 | Reproductive physiology and disease

PDLIM3 knockdown promotes ferroptosis in endometriosis progression via inducing Gli1 degradation and blocking Hedgehog signaling pathway

Endometriosis (EMS) is a chronic gynecological condition affecting approximately 10% of reproductive-age women [ 1 ]. The etiology of EMS is complicated and multifactorial, including local immunity, hormone secretion, environment, and susceptible …

verfasst von:: Mingwei Liu, Xianxian Wang, Jiannan Zhu

Open Access 20.05.2024 | Fertility Preservation

Oocyte retrieval in social fertility preservation: challenging traditional beliefs on gonadotropin dosing and follicular size

In 2012, the American Society for Reproductive Medicine (ASRM) acknowledged that oocyte vitrification for women facing potential fertility decline was no longer experimental (Practice Committees of the ASRM and the Society for Assisted …

verfasst von:: Einat Haikin Herzberger, Mor Semo, Kim Soifer, Netanella Miller, Nitzan Goren Gepstein, Roni Rahav, Mattan Levi, Amir Wiser

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Open Access 17.05.2024 | Genetics

Direct embryonic biopsy with transcervical embryoscopy is an effective method for karyotyping and morphology assessment in miscarriages

Miscarriage, according to the European Society of Human Reproduction (ESHRE), is defined as the spontaneous demise of pregnancy before 24 weeks of gestation [ 1 ]. Approximately 15–25% of all known pregnancies result in miscarriage, which mainly …

verfasst von:: Pinar Calis, Bengisu Akcay, Gurkan Bozdag, Mehmet Erdem, Ahmet Erdem, Meral Yirmibes, Esra Tug, Deniz Karcaaltincaba

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17.05.2024 | Assisted Reproduction Technologies

Intrauterine insemination timing models—LH can only take you so far

Accurately predicting timing of ovulation is a great challenge and of central importance for infertility treatment providers and patients, mostly for timing intercourse or natural cycle–intrauterine insemination (NC-IUI). The timing of …

verfasst von:: Michal Youngster, Eden Moran, Almog Luz, Shachar Reuvenny, Rohi Hourvitz, Tali Ben-Mayor Bashi, Micha Baum, Ettie Maman, Ariel Hourvitz

16.05.2024 | Gamete Biology

The evaluation effect of nanoliposome-loaded Mito-Tempo on sperm parameters during human sperm cryopreservation

Cryopreservation of sperm is an important method, allowing sperm to maintain their genetic integrity and biological function [ 1 ]. Nonetheless, sperm freezing negatively affects the sperm quality. When the sperm is affected by the cryopreservation …

verfasst von:: Rahil Jannatifar, Hamid Piroozmanesh, Seyedeh Saeideh Sahraei, Atefeh Verdi, Elham Asa

16.05.2024 | Letter to the Editor

Fertility preservation written by ChatGPT-4: correspondence

verfasst von:: Hinpetch Daungsupawong, Viroj Wiwanitkit

Open Access 16.05.2024 | Genetics

A heatmap for expected cumulative live birth rate in preimplantation genetic testing for monogenic disorders and chromosomal structural rearrangements

For many decades, couples at risk of transmitting a genetic condition to their offspring could only opt for prenatal testing. In the early nineties, preimplantation genetic testing (PGT) was developed as an alternative to prenatal testing and …

verfasst von:: Annelore Van Der Kelen, Kathelijn Keymolen, Wilfried Cools, Anick De Vos, Laura Pölsler, Michel De Vos, Christophe Blockeel, Elia Fernandez-Gallardo, Martine De Rycke, Veerle Berckmoes, Pieter Verdyck, Frederik Jan Hes, Willem Verpoest

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Open Access 15.05.2024 | Correction

Correction to: Endocrine-disrupting chemical concentrations in follicular fluid and follicular reproductive hormone levels

verfasst von:: Nathalie Hoffmann-Dishon, Zohar Barnett-Itzhaki, Daniel Zalko, Rina Hemi, Nahid Farzam, Russ Hauser, Catherine Racowsky, Andrea A. Baccarelli, Ronit Machtinger

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15.05.2024 | Assisted Reproduction Technologies

International attitudes towards medical and planned oocyte cryopreservation

As techniques to cryopreserve oocytes have improved in recent years, oocyte cryopreservation for both medical and non-medical (planned) reasons (“social egg freezing”) has increased in use [ 1 – 5 ]. In the USA, cycle numbers are well documented …

verfasst von:: Stylianos Vagios, Bei Sun, John Yeh, Caitlin R. Sacha

13.05.2024 | Assisted Reproduction Technologies

Embryo development and live birth in women with one previously failed full IVF/ICSI cycle

Assisted reproductive technologies (ART) have significantly advanced over the past decade, including embryonic endometrial synchrony, the extended culture, and vitrification. However, many couple will not conceive or achieve a live birth in their …

verfasst von:: Wen Wen, Dian Zhang, Xiaohua Liu, Juanzi Shi, He Cai

10.05.2024 | Assisted Reproduction Technologies

Is a day 7 blastocyst predictive of the reproductive potential of sibling day 5 and day 6 blastocysts?

A blastocyst suitable for transfer, vitrification, or biopsy is determined by the morphology of the inner cell mass, trophectoderm, and stage of expansion [ 1 ]. Embryos cultured in vitro most commonly reach the fully expanded blastocyst stage 5 to …

verfasst von:: Jennia Michaeli, Natalie Ge, Ella Huszti, Ellen M. Greenblatt

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