Patients with signs and symptoms of myocardial ischemia despite unobstructed coronary arteries have puzzled clinical cardiologists over several decades [ 1 ]. Substantial advances in invasive and noninvasive diagnostic assessments and targeted …
verfasst von:
Roman Tremmel, Valeria Martínez Pereyra, Incifer Broders, Elke Schaeffeler, Per Hoffmann, Markus M. Nöthen, Raffi Bekeredjian, Udo Sechtem, Matthias Schwab, Peter Ong
Myocardial infarctions in younger people are considered rare events but occur more frequently than generally assumed. It had been shown in 2015 that 1 in 15 myocardial infarctions affect a patient younger than 45 years; the majority of these are …
verfasst von:
Christoph Altmann, Nelu-Adrian Burlacu, Thomas Preuss, Annett Hlousek, Stephan Eddicks, on behalf of the MEDIAN Medical Board Cardiology
Transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) has evolved since its conception in the beginning of the century [ 1 ]. Transcatheter heart valve (THV) iterations and operator experience drastically and reproducibly …
verfasst von:
Joris F. Ooms, Kristoff Cornelis, Harindra C. Wijeysundera, Bert Vandeloo, Jan Van Der Heyden, Jan Kovac, David Wood, Albert Chan, Joanna Wykyrzykowska, Liesbeth Rosseel, Michael Cunnington, Frank van der Kley, Benno Rensing, Michiel Voskuil, David Hildick-Smith, Nicolas M. Van Mieghem
Within the last decades, the prevalence of heart failure (HF) has steadily increased due to ongoing demographic changes related to an overall ageing population [ 1 , 2 ]. Global estimates have shown that approximately 64 million people are affected …
verfasst von:
Alexander Schmitt, Michael Behnes, Kathrin Weidner, Mohammad Abumayyaleh, Marielen Reinhardt, Noah Abel, Felix Lau, Jan Forner, Mohamed Ayoub, Kambis Mashayekhi, Ibrahim Akin, Tobias Schupp
A growing number of patients diagnosed with pulmonary arterial hypertension (PAH) has features suggestive of concomitant left heart disease (LHD), albeit not clinically overt, nor sufficient to cause an elevation in pulmonary artery wedge pressure …
verfasst von:
Matteo Toma, Giulio Savonitto, Carlo Maria Lombardi, Edoardo Airò, Mauro Driussi, Piero Gentile, Luke Howard, Martina Moschella, Emma Di Poi, Matteo Pagnesi, Simonetta Monti, Valentino Collini, Luciana D’Angelo, Veronica Vecchiato, Alberto Giannoni, Marianna Adamo, Davide Barbisan, Carolina Bauleo, Andrea Garascia, Marco Metra, Gianfranco Sinagra, Francesco Lo Giudice, Davide Stolfo, Pietro Ameri
Catheter ablation is frequently employed as first-line therapy of atrial flutter and atrial fibrillation (AF) and is recommended in current guidelines [ 1 ]. The combination of atrial flutter and/or fibrillation with electrical device therapy for …
verfasst von:
Gerrit Frommeyer, Florian Reinke, Johannes Brachmann, Thorsten Lewalter, Roland Richard Tilz, Stephan Willems, Florian Straube, Ibrahim Akin, Patrick Lugenbiel, Matthias Hochadel, Jochen Senges, Lars Eckardt
The aetiology of heart failure with preserved ejection fraction (HFpEF) is heterogenous and overlaps with that of several comorbidities like atrial fibrillation, diabetes mellitus, chronic kidney disease, valvular heart disease, iron deficiency …
verfasst von:
Stephan von Haehling, Birgit Assmus, Tarek Bekfani, Elke Dworatzek, Frank Edelmann, Djawid Hashemi, Kristian Hellenkamp, Tibor Kempf, Philipp Raake, Katharina A. Schütt, Rolf Wachter, Paul Christian Schulze, Gerd Hasenfuss, Michael Böhm, Johann Bauersachs
Cardiac resynchronization therapy (CRT) is a well-established, effective device therapy for a subgroup of patients who are suffering from heart failure with reduced ejection fraction (HFrEF) and have persistent symptoms of heart failure and wide …
verfasst von:
Richárd Masszi, Előd-János Zsigmond, Réka Ehrenberger, Caner Turan, Péter Fehérvári, Brigitta Teutsch, Zsolt Molnár, Zsófia Drobni, Hajnalka Vágó, Péter Hegyi, Béla Merkely, Annamária Kosztin
Cardiac wasting–associated cardiomyopathy has recently been described in patients with advanced-stage cancer [ 1 , 2 ] and was shown to be associated with reduced physical performance, increased all-cause mortality, and inflammation. In preclinical …
verfasst von:
Ann-Kathrin Fröhlich, Jan Porthun, Khawaja M. Talha, Alessia Lena, Sara Hadzibegovic, Ursula Wilkenshoff, Frederike Sonntag, Anja Nikolski, Luisa Valentina Ramer, Tanja Zeller, Ulrich Keller, Lars Bullinger, Stefan D. Anker, Wilhelm Haverkamp, Stephan von Haehling, Wolfram Doehner, Ursula Rauch, Carsten Skurk, John G. F. Cleland, Javed Butler, Andrew J. S. Coats, Ulf Landmesser, Mahir Karakas, Markus S. Anker
Advanced lung disease is associated with severely impaired quality of life and dramatically reduced life expectancy [ 1 – 3 ]. Though well established, lung transplantation as the ultimate therapeutic option is highly limited by the scarcity of …
verfasst von:
Enzo Lüsebrink, Nils Gade, Paula Seifert, Felix Ceelen, Tobias Veit, Fabian Fohrer, Sabine Hoffmann, Julia Höpler, Leonhard Binzenhöfer, Daniel Roden, Inas Saleh, Hugo Lanz, Sebastian Michel, Christian Schneider, Michael Irlbeck, Roland Tomasi, Rudolf Hatz, Jörg Hausleiter, Christian Hagl, Christina Magnussen, Benjamin Meder, Sebastian Zimmer, Peter Luedike, Andreas Schäfer, Martin Orban, Katrin Milger, Jürgen Behr, Steffen Massberg, Nikolaus Kneidinger
Heart failure (HF) is a heterogenous, morbid condition that affects over 6.5 million adults in the USA [ 1 ]. Mortality risk, while variable, is considerable and approaches 50% at 5 years after HF diagnosis with little variation across left …
verfasst von:
Faraz S. Ahmad, Ted Ling Hu, Eric D. Adler, Lucia C. Petito, Ramsey M. Wehbe, Jane E. Wilcox, R. Kannan Mutharasan, Beatrice Nardone, Matevz Tadel, Barry Greenberg, Avi Yagil, Claudio Campagnari
Venous thromboembolism and particularly acute pulmonary embolism (PE) are a leading cardiovascular cause of death after myocardial infarction and stroke [ 1 ] and have a substantial impact on the morbidity and mortality of the population in Europe …
verfasst von:
Katharina Mohr, Lukas Hobohm, Klaus Kaier, Ioannis T. Farmakis, Luca Valerio, Stefano Barco, Christina Abele, Thomas Münzel, Thomas Neusius, Stavros Konstantinides, Harald Binder, Karsten Keller
Transcatheter edge-to-edge repair of the mitral valve (M-TEER) has emerged as a safe and less invasive therapeutic alternative in patients with severe mitral regurgitation and at high-risk for surgical mitral valve repair [ 1 – 4 ]. M-TEER is an …
verfasst von:
Philippa Jaeger, Ioannis Toskas, Jessica-Kristin Henes, Serhii Shcherbyna, Frederic Schwarz, Miriam Euper, Peter Seizer, Harald Langer, Andreas E. May, Tobias Geisler, Meinrad Gawaz, Jürgen Schreieck, Dominik Rath
Global longitudinal strain (GLS) by speckle tracking echocardiography is a sensitive marker of global systolic left ventricular (LV) function [ 1 ]. The bulk of literature in support of GLS as a predictor of adverse outcome in heart disease has …
verfasst von:
Joel Lenell, Bertil Lindahl, David Erlinge, Tomas Jernberg, Jonas Spaak, Tomasz Baron
Improved survival among cancer patients in recent years resulted in larger numbers of patients having concomitant diagnoses of both cancer and cardiovascular disease (CVD). Moreover, patients with cancer are at increased risk for an acute coronary …
verfasst von:
Inbar Nardi Agmon, Ori Rahat, Roy Beigel, Tal Ovdat, Manhal Habib, Oran Tzuman, Limor Ilan Bushari, Ran Kornowski, Katia Orvin
In contemporary percutaneous coronary intervention (PCI) practice, dealing with coronary artery calcification remains a challenge. The current PCI population includes predominantly older individuals with a higher incidence of comorbidities, making …
verfasst von:
Nader Mankerious, Gert Richardt, Abdelhakim Allali, Volker Geist, Adnan Kastrati, Mohamed El-Mawardy, Tobias Rheude, Dmitriy Sulimov, Ralph Toelg, Mohamed Abdel-Wahab
Pulmonary vein isolation (PVI), being more effective at maintaining sinus rhythm than medical therapy, has become the key therapy in the treatment of symptomatic AF [ 1 – 3 ].
verfasst von:
Jan-Hendrik van den Bruck, Jonas Wörmann, Arian Sultan, Karlo Filipovic, Katharina Seuthe, Susanne Erlhöfer, Cornelia Scheurlen, Sebastian Dittrich, Jan-Hendrik Schipper, Jakob Lüker, Daniel Steven
