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Die Anaesthesiologie
Erschienen in: Der Anaesthesist 10/2006

01.10.2006 | Intensivmedizin

Kohlenmonoxid – Gift oder potenzielles Therapeutikum?

verfasst von: Dr. A. Hoetzel, R. Schmidt

Erschienen in: Die Anaesthesiologie | Ausgabe 10/2006

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Zusammenfassung

Kohlenmonoxid (CO) ist weit mehr als nur ein toxisches Gas. Es wird endogen durch das Enzym Hämoxygenase synthetisiert und erfüllt essenzielle Funktionen unter physiologischen und pathophysiologischen Bedingungen. Untersuchungen der letzten Jahre attestieren CO antioxidative, antiinflammatorische, antiproliferative, antiapoptotische und vasodilatative Eigenschaften. Insbesondere bei anästhesiologisch und intensivmedizinisch relevanten Krankheitsbildern, wie dem „adult respiratory distress syndrome“ (ARDS), der Sepsis oder bei Organtransplantationen konnten in experimentellen Modellen zytoprotektive Wirkungen durch niedrig dosierte CO-Applikation nachgewiesen werden. Im Hinblick auf eine potenzielle therapeutische Anwendung beim Menschen werden in dieser Übersichtsarbeit funktionelle, protektive und toxische Wirkungen im Kontext des aktuellen Wissensstands kritisch diskutiert.
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Metadaten
Titel
Kohlenmonoxid – Gift oder potenzielles Therapeutikum?
verfasst von
Dr. A. Hoetzel
R. Schmidt
Publikationsdatum
01.10.2006
Verlag
Springer-Verlag
Erschienen in
Die Anaesthesiologie / Ausgabe 10/2006
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI
https://doi.org/10.1007/s00101-006-1056-x

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