Motor studies | 1997 | 2013 | ||
---|---|---|---|---|
Right | Left | Right | Left | |
Nerve | ||||
Tibial | ||||
Latency (ms) |
5.8
|
5.4
|
6.5
| |
Amplitude (mV) |
0.8
|
1.1
|
0.05
| |
Conduction velocity m/s |
36
|
36
| ||
F Wave (max) ms |
65.5
|
Absent
|
Absent
| |
Peroneal | ||||
Latency (ms): ankle |
5.45
| |||
Amplitude (mV): ankle |
0.3
| |||
Amplitude (mV): above knee |
0.3
| |||
Conduction velocity (m/s) |
30.5
| |||
F Wave (max) ms |
Absent
| |||
Ulnar | ||||
Latency (ms): wrist | 3.30 | |||
Amplitude (mV): wrist | 11.7 | |||
Amplitude (mV): above elbow | 9.6 | |||
Conduction velocity (m/s) | 45.6 | |||
F Wave (min) ms | 33.15 | |||
Median | ||||
Latency (ms): wrist | 4.3 | 3.90 | 3.75 | |
Amplitude (mV): wrist | 18.8 | 16.0 | 14.9 | |
Amplitude (mV): elbow | 17.3 | 14.8 | 7.1 | |
Conduction velocity (m/s) | 52 | 48 | 43.3 | |
F Wave (min) ms | 34.25 |
Sensory studies | 1997 | 2013 | ||
---|---|---|---|---|
Right | Left | Right | Left | |
Nerve | ||||
Sural | ||||
Latency (peak) ms |
Absent
|
Absent
|
Absent
|
Absent
|
Amplitude (peak–peak) µV |
Absent
|
Absent
|
Absent
|
Absent
|
Radial | ||||
Latency (onset) ms | 1.90 | |||
Latency (peak) ms | 2.80 | 2.80 | 2.60 | |
Amplitude (peak–peak) µV | 10.0 | 10.0 |
0.26
| |
Conduction velocity (onset) m/s | 44.7 | |||
Ulnar | ||||
Latency (peak) ms | 3.0 | 3.4 |
Absent
|
Absent
|
Amplitude (peak–peak) µV |
3.1
|
1.0
|
Absent
|
Absent
|
Median | ||||
Latency (peak) ms | 4.10 | 4.10 |
Absent
|
Absent
|
Amplitude (peak–peak) µV |
2.20
|
2.10
|
Absent
|
Absent
|
Electromyography | 1997 | 2013 |
---|---|---|
Muscle | ||
Right tibialis anterior | No spontaneous activity, Normal pattern of motor unit recruitment with motor units up to 2.5 mV | No abnormal spontaneous activity. Voluntary recruitment moderately severely reduced in density with an excess of slightly unstable irregular motor unit potentials: durations up to 20 ms, amplitude up to 10 mV |
Right first dorsal interosseous | No spontaneous activity, Normal pattern of motor unit recruitment with motor units up to 2.5 mV |
Blood tests |
Hb 11 g/dl, WBC 5.34 × 109/L, platelets 119 × 109/L, MCV 101.5 fl, neutrophils 3.56 × 109/L |
Clotting screen normal |
Urea 10.1 µmol/L, creatinine 151 µmol/L, eGFR 41 ml/min |
Albumin 37 g/L |
Liver function tests normal |
IgA 2.2 g/L, IgG 9.8 g/L, IgM 1.2 g/L, no serum paraprotein detected |
Serum free light chains: Kappa 26.8 mg/L, Lambda 20.9 mg/L. K/L ratio 1.28 |
Lipid profile normal |
CRP <1 mg/L |
NT- pro BNP 129pMol/L |
Cardiac Troponin 0.015T ng/mL |
Urine |
Creatinine clearance 35.6 ml/min |
24 h urinary protein loss 0.31 g |
Bence Jones protein not detected |
Genetic testing |
PMP22 duplication/deletion negative |
Transthyretin, SPTLC1, Rab7 sequencing negative |
Amyloid deposition investigations |
SAP Scan: no visceral organ uptake |
DPD Scan: no cardiac uptake |
Fat aspirate: no Congo red staining |
Other tests |
MRI brain: age appropriate cerebral atrophy |
ECG: normal sinus rhythm |
Echocardiogram: IVSd 1.1 cm. Mild TR. No evidence of cardiac dysfunction. |