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Erschienen in: European Child & Adolescent Psychiatry 2/2012

01.02.2012 | Original Contribution

Late potentials in the signal-averaged electrocardiogram in pre-pubertal children with ADHD, before and after methylphenidate treatment

verfasst von: Eitan Nahshoni, Pavel Golubchik, Jonathan Glazer, Jonathan Sever, Boris Strasberg, Shula Imbar, Gal Shoval, Abraham Weizman, Gil Zalsman

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 2/2012

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Abstract

Reports on sudden cardiac death (SCD) of children and adolescents treated with stimulant agents have raised concerns regarding the need for cardiovascular monitoring and risk stratification schedules. Cardiac ventricular late potentials (LPs) represent delayed ventricular activation that might predispose to fatal ventricular arrhythmias and SCD in cardiac patients. LPs have not previously been measured in children with attention deficit/hyperactivity disorder (ADHD). LPs were measured in 18 physically healthy ADHD children (5 girls and 13 boys, age 11.9 ± 2.5 years, treatment duration 2.6 ± 1.9 years) before and 2 h after oral methylphenidate administration. No significant changes were detected and LPs were found to be within normal ranges. In conclusion, this preliminary small-scale study suggests that methylphenidate in physically healthy children with ADHD was not associated with cardiac ventricular LPs, suggesting the safety of the agent in this age group.
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Metadaten
Titel
Late potentials in the signal-averaged electrocardiogram in pre-pubertal children with ADHD, before and after methylphenidate treatment
verfasst von
Eitan Nahshoni
Pavel Golubchik
Jonathan Glazer
Jonathan Sever
Boris Strasberg
Shula Imbar
Gal Shoval
Abraham Weizman
Gil Zalsman
Publikationsdatum
01.02.2012
Verlag
Springer-Verlag
Erschienen in
European Child & Adolescent Psychiatry / Ausgabe 2/2012
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-011-0233-x

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