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Role of extracellular matrix metalloproteinases in cardiac remodelling

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Abstract

The latent collagenolytic system is an intrinsic part of normal myocardium. Controlled activation of this system becomes necessary in ventricular chamber remodeling following inflammation and injury, such as dilated cardiomyopathy and myocardial infarction. Evidence exists to indicate activation of collagenolytic enzymes in patients with congestive heart failure and dilated, dysfunctional ventricles due to cardiomyopathy and ischemic heart disease.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Missouri-Health Sciences Center, Columbia, Missouri

    Suresh C. Tyagi, Venugopala S. Bheemanathini, Deepak Mandi, Hanumanth K. Reddy & Donald J. Voelker

  2. Department of Biochemistry, University of Missouri-Health Sciences Center, Columbia, Missouri

    Suresh C. Tyagi, Venugopala S. Bheemanathini, Deepak Mandi, Hanumanth K. Reddy & Donald J. Voelker

  3. Dalton Cardiovascular Research Center, University of Missouri-Health Sciences Center, Columbia, Missouri

    Suresh C. Tyagi, Venugopala S. Bheemanathini, Deepak Mandi, Hanumanth K. Reddy & Donald J. Voelker

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  1. Suresh C. Tyagi
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  2. Venugopala S. Bheemanathini
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  5. Donald J. Voelker
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Tyagi, S.C., Bheemanathini, V.S., Mandi, D. et al. Role of extracellular matrix metalloproteinases in cardiac remodelling. Heart Failure Rev 1, 73–80 (1996). https://doi.org/10.1007/BF00128558

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  • DOI: https://doi.org/10.1007/BF00128558

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