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Monatsschrift Kinderheilkunde
Erschienen in: Monatsschrift Kinderheilkunde 3/2011

01.03.2011 | Leitthema

Beatmungsassoziierte Pneumonie bei Kindern

verfasst von: PD. Dr. A. Simon, E. Tutdibi, L. von Müller, L. Gortner

Erschienen in: Monatsschrift Kinderheilkunde | Ausgabe 3/2011

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Zusammenfassung

Die beatmungsassoziierte Pneumonie (VAP: „ventilator-associated pneumonia“) im Kindesalter ist nach aktuellen Daten der KISS-Studie (KISS: Krankenhausinfektionssurveillancesystem) eine in Deutschland insgesamt seltene, aber potenziell lebensbedrohliche Komplikation der pädiatrischen Intensivtherapie, die besonders häufig bei Kindern mit schweren Grunderkrankungen oder angeborenen Fehlbildungen auftritt. Im vorliegenden Beitrag werden die aktuellen Konzepte der Diagnostik, Prävention und Therapie der VAP dargestellt. Dabei wird hervorgehoben, dass ein erheblicher Teil dieser Ereignisse durch eine strukturierte Intervention (evidenzbasiertes Maßnahmenbündel) verhindert werden kann.
Literatur
1.
Adams ES (2009) A critical appraisal of „transfusion strategies for patients in pediatric intensive care units“ by Lacroix J, Hebert PC, Hutchison, et al (N Engl J Med 2007; 356:1609–1619). Pediatr Crit Care Med 10:393–396PubMed
2.
Almuneef M, Memish ZA, Balkhy HH et al (2004) Ventilator-associated pneumonia in a pediatric intensive care unit in Saudi Arabia: a 30-month prospective surveillance. Infect Control Hosp Epidemiol 25:753–758PubMed
3.
Aly H, Badawy M, El-Kholy A et al (2008) Randomized, controlled trial on tracheal colonization of ventilated infants: can gravity prevent ventilator-associated pneumonia? Pediatrics 122:770–774PubMed
4.
Amantea SL, Piva JP, Sanches PR et al (2004) Oropharyngeal aspiration in pediatric patients with endotracheal intubation. Pediatr Crit Care Med 5:152–156PubMed
5.
Baltimore RS (2003) The difficulty of diagnosing ventilator-associated pneumonia. Pediatrics 112:1420–1421PubMed
6.
Barret JP, Jeschke MG, Herndon DN (2001) Selective decontamination of the digestive tract in severely burned pediatric patients. Burns 27:439–445PubMed
7.
Bernet V, Hug MI, Frey B (2005) Predictive factors for the success of noninvasive mask ventilation in infants and children with acute respiratory failure. Pediatr Crit Care Med 6:660–664PubMed
8.
Berry AM, Davidson PM, Masters J et al (2007) Systematic literature review of oral hygiene practices for intensive care patients receiving mechanical ventilation. Am J Crit Care 16:552–563PubMed
9.
Bigham MT, Amato R, Bondurrant P et al (2009) Ventilator-associated pneumonia in the pediatric intensive care unit: characterizing the problem and implementing a sustainable solution. J Pediatr 154:582–587.e2PubMed
10.
Bindl L, Nicolai T (2005) Management of septic shock and acquired respiratory distress syndrome in pediatric cancer patients. Klin Padiatr [Suppl 1] 217:130–142
11.
Bisgaard H, Hermansen MN, Bonnelykke K et al (2010) Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study. BMJ 341:c4978PubMed
12.
Black S, Lo E, Madriga M et al (2000) Nosocomial pneumonia in the PICU. Abstract. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Toronto, Ontario, Canada, September 17–20, Abstract K-452
13.
Bouza E, Burillo A (2009) Advances in the prevention and management of ventilator-associated pneumonia. Curr Opin Infect Dis 22:345–351PubMed
14.
Bradley EA (2010) Considerations unique to pediatrics for clinical trial design in hospital-acquired pneumonia and ventilator-associated pneumonia. Clin Infect Dis 51:S136–S143PubMed
15.
Brilli RJ, Goldstein B (2005) Pediatric sepsis definitions: past, present, and future. Pediatr Crit Care Med 6:S6–S8PubMed
16.
Brilli RJ, Sparling KW, Lake MR et al (2008) The business case for preventing ventilator-associated pneumonia in pediatric intensive care unit patients. Jt Comm J Qual Patient Saf 34:629–638PubMed
17.
Brook I (1996) Treatment of aspiration or tracheostomy-associated pneumonia in neurologically impaired children: effect of antimicrobials effective against anaerobic bacteria. Int J Pediatr Otorhinolaryngol 35:171–177PubMed
18.
Burmester M, Mok Q (2001) How safe is non-bronchoscopic bronchoalveolar lavage in critically ill mechanically ventilated children? Intensive Care Med 27:716–721PubMed
19.
Carratala J, Garcia-Vidal C (2008) What is healthcare-associated pneumonia and how is it managed? Curr Opin Infect Dis 21:168–173PubMed
20.
Cason Cl, Tyner T, Saunders S et al (2007) Nurses‘ implementation of guidelines for ventilator-associated pneumonia from the Centers for Disease Control and Prevention. Am J Crit Care 16:28–38PubMed
21.
Chan EY, Ruest A, Meade MO et al (2007) Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ 334:889PubMed
22.
Chastre J, Wolff M, Fagon JY et al (2003) Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA 290:2588–2598PubMed
23.
Chastre J, Trouillet JL, Combes A et al (2010) Diagnostic techniques and procedures for establishing the microbial etiology of ventilator-associated pneumonia for clinical trials: the pros for quantitative cultures. Clin Infect Dis [Suppl 1] 51:S88–S92
24.
Chlebicki MP, Safdar N (2007) Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis. Crit Care Med 35:595–602PubMed
25.
Cook DJ, Meade MO, Hand LE et al (2002) Toward understanding evidence uptake: semirecumbency for pneumonia prevention. Crit Care Med 30:1472–1477PubMed
26.
Corbett HJ, Mann KS, Mitra I et al (2007) Tracheostomy – a 10-year experience from a UK pediatric surgical center. J Pediatr Surg 42:1251–1254PubMed
27.
Cordero L, Sananes M, Ayers LW (2000) Comparison of a closed (Trach Care MAC) with an open endotracheal suction system in small premature infants. J Perinatol 20:151–156PubMed
28.
Cordero L, Ayers LW, Miller RR et al (2002) Surveillance of ventilator-associated pneumonia in very-low-birth-weight infants. Am J Infect Control 30:32–39PubMed
29.
Crnich CJ, Safdar N, Maki DG (2005) The role of the intensive care unit environment in the pathogenesis and prevention of ventilator-associated pneumonia. Respir Care 50:813–836PubMed
30.
Delaney A, Gray H, Laupland KB et al (2006) Kinetic bed therapy to prevent nosocomial pneumonia in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care 10:R70PubMed
31.
Deutsch ES (2010) Tracheostomy: pediatric considerations. Respir Care 55:1082–1090PubMed
32.
Dullenkopf A, Gerber AC, Weiss M (2005) Fit and seal characteristics of a new paediatric tracheal tube with high volume-low pressure polyurethane cuff. Acta Anaesthesiol Scand 49:232–237PubMed
33.
Eckmanns T, Oppert M, Martin M et al (2008) An outbreak of hospital-acquired Pseudomonas aeruginosa infection caused by contaminated bottled water in intensive care units. Clin Microbiol Infect 14:454–458PubMed
34.
Elward AM (2003) Pediatric ventilator-associated pneumonia. Pediatr Infect Dis J 22:445–446PubMed
35.
Elward AM, Fraser VJ (2006) Risk factors for nosocomial primary bloodstream infection in pediatric intensive care unit patients: a 2-year prospective cohort study. Infect Control Hosp Epidemiol 27:553–560PubMed
36.
Elward AM, Warren DK, Fraser VJ (2002) Ventilator-associated pneumonia in pediatric intensive care unit patients: risk factors and outcomes. Pediatrics 109:758–764PubMed
37.
Essouri S, Chevret L, Durand P et al (2006) Noninvasive positive pressure ventilation: five years of experience in a pediatric intensive care unit. Pediatr Crit Care Med 7:329–334PubMed
38.
Exner M, Kramer A, Lajoie L et al (2005) Prevention and control of health care-associated waterborne infections in health care facilities. Am J Infect Control 33:S26–S40PubMed
39.
Fayon MJ, Tucci M, Lacroix J et al (1997) Nosocomial pneumonia and tracheitis in a pediatric intensive care unit: a prospective study. Am J Respir Crit Care Med 155:162–169PubMed
40.
Fields LB (2008) Oral care intervention to reduce incidence of ventilator-associated pneumonia in the neurologic intensive care unit. J Neurosci Nurs 40:291–298PubMed
41.
Fischer JE, Allen P, Fanconi S (2000) Delay of extubation in neonates and children after cardiac surgery: impact of ventilator-associated pneumonia. Intensive Care Med 26:942–949PubMed
42.
Fischer JE, Ramser M, Fanconi S (2000) Use of antibiotics in pediatric intensive care and potential savings. Intensive Care Med 26:959–966PubMed
43.
Flynn PE, Black AE, Mitchell V (2008) The use of cuffed tracheal tubes for paediatric tracheal intubation, a survey of specialist practice in the United Kingdom. Eur J Anaesthesiol 25:685–688PubMed
44.
Foglia E, Hollenbeak CS, Fraser A et al (2006) Cost associated with nosocomial bloodstream infection and ventilator-associated pneumonia in pediatric intensive care unit patients. Abstract. 16th Annual Meeting Society of Healthcare Epidemiology of America (SHEA), Chicago, Illinois, March 18–21, Abstract 109
45.
Foglia E, Meier MD, Elward A (2007) Ventilator-associated pneumonia in neonatal and pediatric intensive care unit patients. Clin Microbiol Rev 20:409–425PubMed
46.
Fujitani S, Yu VL (2006) Quantitative cultures for diagnosing ventilator-associated pneumonia: a critique. Clin Infect Dis [Suppl 2] 43:S106–S113
47.
Garland JS, Alex CP, Uhing MR et al (2009) Pilot trial to compare tolerance of chlorhexidine gluconate to povidone-iodine antisepsis for central venous catheter placement in neonates. J Perinatol 29:808–813PubMed
48.
Gastmeier P, Sohr D, Schwab F et al (2008) Ten years of KISS: the most important requirements for success. J Hosp Infect [Suppl 1] 70:11–16
49.
Gastmeier P, Sohr D, Geffers C et al (2009) Early- and late-onset pneumonia: is this still a useful classification? Antimicrob Agents Chemother 53:2714–2718PubMed
50.
Gauvin F, Lacroix J, Guertin MC et al (2002) Reproducibility of blind protected bronchoalveolar lavage in mechanically ventilated children. Am J Respir Crit Care Med 165:1618–1623PubMed
51.
Gauvin F, Dassa C, Chaibou M et al (2003) Ventilator-associated pneumonia in intubated children: comparison of different diagnostic methods. Pediatr Crit Care Med 4:437–443PubMed
52.
Geffers C, Schwab F, Gastmeier P (2009) Nosokomiale Infektionen bei pädiatrischen Intensivpflegepatienten – Daten aus ITS-KISS. Hyg Med 34:336–342
53.
Goldstein B, Giroir B, Randolph A (2005) International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 6:2–8PubMed
54.
Goldstein I, Chastre J, Rouby JJ (2006) Novel and innovative strategies to treat ventilator-associated pneumonia: optimizing the duration of therapy and nebulizing antimicrobial agents. Semin Respir Crit Care Med 27:82–91PubMed
55.
Grohskopf LA, Sinkowitz-Cochran RL, Garrett DO et al (2002) A national point-prevalence survey of pediatric intensive care unit-acquired infections in the United States. J Pediatr 140:432–438PubMed
56.
Gujadhur R, Helme BW, Sanni A et al (2005) Continuous subglottic suction is effective for prevention of ventilator associated pneumonia. Interact Cardiovasc Thorac Surg 4:110–115PubMed
57.
Haas LE, Schultz MJ (2010) Selective decontamination of the digestive tract reduces pneumonia and mortality. Crit Care Res Pract 2010:501031PubMed
58.
Harris JA (2006) Infection control in pediatric extended care facilities. Infect Control Hosp Epidemiol 27:598–603PubMed
59.
Hauer T, Jonas D, Dettenkofer M et al (1999) Tea as a source of Acinetobacter baumannii ventilator-associated pneumonia? Infect Control Hosp Epidemiol 20:594PubMed
60.
Hsieh TC, Hsia SH, Wu CT et al (2010) Frequency of ventilator-associated pneumonia with 3-day versus 7-day ventilator circuit changes. Pediatr Neonatol 51:37–43PubMed
61.
Hubner NO, Siebert J, Kramer A (2010) Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds. Skin Pharmacol Physiol 23:244–258PubMed
62.
Jantausch BA, Deville J, Adler S et al (2003) Linezolid for the treatment of children with bacteremia or nosocomial pneumonia caused by resistant gram-positive bacterial pathogens. Pediatr Infect Dis J 22:S164–S171PubMed
63.
Javouhey E, Barats A, Richard N et al (2008) Non-invasive ventilation as primary ventilatory support for infants with severe bronchiolitis. Intensive Care Med 34:1608–1614PubMed
64.
Joffe A, Anton N, Lequier L et al (2009) Nutritional support for critically ill children. Cochrane Database Syst Rev 2:CD005144PubMed
65.
Koksal N, Hacimustafaoglul M, Celebi S et al (2006) Nonbronchoscopic bronchoalveolar lavage for diagnosing ventilator-associated pneumonia in newborns. Turk J Pediatr 48:213–220PubMed
66.
Kola A, Gastmeier P (2007) Efficacy of oral chlorhexidine in preventing lower respiratory tract infections. Meta-analysis of randomized controlled trials. J Hosp Infect 66:207–216PubMed
67.
Kola A, Eckmanns T, Gastmeier P (2005) Efficacy of heat and moisture exchangers in preventing ventilator-associated pneumonia: meta-analysis of randomized controlled trials. Intensive Care Med 31:5–11PubMed
68.
Kollef MH, Afessa B, Anzueto A et al (2008) Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trial. JAMA 300:805–813PubMed
69.
Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch Institut (2000) Händehygiene – Mitteilung der Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 43:230–233
70.
Kommission für Krankenhaushygiene und Infektionsprävention am Robert Koch-Institut (2001) Anforderungen an die Hygiene bei der Aufbereitung von Medizinprodukten – Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (RKI) und des Bundesinstitutes für Arzneimittel und Medizinprodukte (BfArM) zu den „Anforderungen an die Hygiene bei der Aufbereitung von Medizinprodukten“. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 44:1115–1126
71.
Kommission für Krankenhaushygiene und Infektionsprävention (2004) Anforderung an die Hygiene bei der Reinigung und Desinfektion von Flächen. Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention am Robert Koch-Institut. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:51–61
72.
Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (2007) Empfehlung zur Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1500 g. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:1265–1303
73.
Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (2007) Anforderungen der Krankenhaushygiene und des Arbeitsschutzes an die Hygienebekleidung und persönliche Schutzausrüstung. Epidemiol Bull 2007:3–4
74.
Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (2010) Anforderungen an die Hygiene bei der medizinischen Versorgung von immunsupprimierten Patienten – Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut (RKI). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 53:357–388
75.
Labenne M, Poyart C, Rambaud C et al (1999) Blind protected specimen brush and bronchoalveolar lavage in ventilated children. Crit Care Med 27:2537–2543PubMed
76.
Lacroix J, Hebert PC, Hutchison JS et al (2007) Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 356:1609–1619PubMed
77.
Leclerc F, Wallet F (2003) Ventilator-associated pneumonia in intubated and mechanically ventilated children: challenges in diagnosis. Pediatr Crit Care Med 4:492–494PubMed
78.
Liberati A, D’Amico R, Pifferi S et al (2009) Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev 4:CD000022PubMed
79.
Lopriore E, Markhorst DG, Gemke RJ (2002) Ventilator-associated pneumonia and upper airway colonisation with gram negative bacilli: the role of stress ulcer prophylaxis in children. Intensive Care Med 28:763–767PubMed
80.
Lorente L, Blot S, Rello J (2010) New issues and controversies in the prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med 182:870–876PubMed
81.
Lyons KA, Brilli RJ, Wieman RA et al (2002) Continuation of transpyloric feeding during weaning of mechanical ventilation and tracheal extubation in children: a randomized controlled trial. JPEN J Parenter Enteral Nutr 26:209–213PubMed
82.
Mclean-Tooke A, Spickett GP, Gennery AR (2007) Immunodeficiency and autoimmunity in 22q11.2 deletion syndrome. Scand J Immunol 66:1–7PubMed
83.
Meert KL, Daphtary KM, Metheny NA (2004) Gastric vs small-bowel feeding in critically ill children receiving mechanical ventilation: a randomized controlled trial. Chest 126:872–878PubMed
84.
Milstone AM, Bryant KA, Huskins WC et al (2010) The past, present, and future of healthcare-associated infection prevention in pediatrics: multidrug-resistant organisms. Infect Control Hosp Epidemiol [Suppl 1] 31:S18–S21
85.
Morar P, Makura Z, Jones A et al (2000) Topical antibiotics on tracheostoma prevents exogenous colonization and infection of lower airways in children. Chest 117:513–518PubMed
86.
Morar P, Singh V, Makura Z et al (2002) Oropharyngeal carriage and lower airway colonisation/infection in 45 tracheotomised children. Thorax 57:1015–1020PubMed
87.
Nationales Referenzzentrum (NRZ) für Surveillance von nosokomialen Infektionen am Institut für Hygiene und Umweltmedizin (2008) CDC Definition nosokomialer Infektionen (CDC Definitionen), 6. Auflage. Robert Koch-Institut, Berlin
88.
Newth CJ, Venkataraman S, Willson DF et al (2009) Weaning and extubation readiness in pediatric patients. Pediatr Crit Care Med 10:1–11PubMed
89.
Niederman MS (2010) The argument against using quantitative cultures in clinical trials and for the management of ventilator-associated pneumonia. Clin Infect Dis [Suppl 1] 51:S93–S99
90.
Norris SC, Barnes AK, Roberts TD (2009) When ventilator-associated pneumonias haunt your NICU – one unit’s story. Neonatal Netw 28:59–66PubMed
91.
Oostdijk EA, De Smet AM, Blok HE et al (2010) Ecological effects of selective decontamination on resistant gram-negative bacterial colonization. Am J Respir Crit Care Med 181:452–457PubMed
92.
Palmer LB (2009) Aerosolized antibiotics in critically ill ventilated patients. Curr Opin Crit Care 15:413–418PubMed
93.
Pancera CF, Hayashi M, Fregnani JH et al (2008) Noninvasive ventilation in immunocompromised pediatric patients: eight years of experience in a pediatric oncology intensive care unit. J Pediatr Hematol Oncol 30:533–538PubMed
94.
Patel SJ, Larson EL, Kubin CJ et al (2007) A review of antimicrobial control strategies in hospitalized and ambulatory pediatric populations. Pediatr Infect Dis J 26:531–537PubMed
95.
Pearson LS, Hutton JL (2002) A controlled trial to compare the ability of foam swabs and toothbrushes to remove dental plaque. J Adv Nurs 39:480–489PubMed
96.
Pineda LA, Saliba RG, El Solh AA (2006) Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia: a meta-analysis. Crit Care 10:R35PubMed
97.
Potocki M, Goette J, Szucs TD et al (2003) Prospective survey of antibiotic utilization in pediatric hospitalized patients to identify targets for improvement of prescription. Infection 31:398–403PubMed
98.
Principi N, Esposito S (2007) Ventilator-associated pneumonia (VAP) in pediatric intensive care units. Pediatr Infect Dis J 26:841–844PubMed
99.
Principi N, Esposito S (2010) Management of severe community-acquired pneumonia of children in developing and developed countries. Thorax Oct 21. [Epub ahead of print]
100.
Rello J, Lode H, Cornaglia G et al (2010) A European care bundle for prevention of ventilator-associated pneumonia. Intensive Care Med 36:773–780PubMed
101.
Renesse A von, Schildgen O, Klinkenberg D et al (2009) Respiratory syncytial virus infection in children admitted to hospital but ventilated mechanically for other reasons. J Med Virol 81:160–166
102.
Ruza F, Alvarado F, Herruzo R et al (1998) Prevention of nosocomial infection in a pediatric intensive care unit (PICU) through the use of selective digestive decontamination. Eur J Epidemiol 14:719–727PubMed
103.
Safdar N, Crnich CJ, Maki DG (2005) The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for prevention. Respir Care 50:725–741PubMed
104.
Safdar N, Dezfulian C, Collard HR et al (2005) Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 33:2184–2193PubMed
105.
Safdar A, Shelburne SA, Evans SE et al (2009) Inhaled therapeutics for prevention and treatment of pneumonia. Expert Opin Drug Saf 8:435–449PubMed
106.
Saiman L, Goldfarb J, Kaplan SA et al (2003) Safety and tolerability of linezolid in children. Pediatr Infect Dis J 22:S193–S200PubMed
107.
Samransamruajkit R, Jirapaiboonsuk S, Siritantiwat S et al (2010) Effect of frequency of ventilator circuit changes (3 vs 7 days) on the rate of ventilator-associated pneumonia in PICU. J Crit Care 25:56–61PubMed
108.
Schultz TR, Lin RJ, Watzman HM et al (2001) Weaning children from mechanical ventilation: a prospective randomized trial of protocol-directed versus physician-directed weaning. Respir Care 46:772–782PubMed
109.
Schulz-Stuebner S, Kniehl E, Sitzmann F (2010) Die Rolle der Mundpflege bei der Prävention beatmungsassoziierter Pneumonien. Krankenhaushygiene up2date 5:177–190
110.
Siempos II, Vardakas KZ, Falagas ME (2008) Closed tracheal suction systems for prevention of ventilator-associated pneumonia. Br J Anaesth 100:299–306PubMed
111.
Siempos II, Ntaidou TK, Falagas ME (2010) Impact of the administration of probiotics on the incidence of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. Crit Care Med 38:954–962PubMed
112.
Simon A, Krawtschenko O, Reiffert SM et al (2008) Outbreaks of Pseudomonas aeruginosa in pediatric patients – clinical aspects, risk factors and management. J Pediatr Infect Dis 3:249–269
113.
Simon A, Müller A, Franz A et al (2009) Erfassung nosokomialer und Gesundheitssystem-assoziierter Infektionen in der Pädiatrie – Gemeinsame Stellungnahme der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI) und der Deutschen Gesellschaft für Krankenhaushygiene (DGKH). Monatsschr Kinderheilkd 157:166–172
114.
Srinivasan A, Wolfenden LL, Song X et al (2003) An outbreak of Pseudomonas aeruginosa infections associated with flexible bronchoscopes. N Engl J Med 348:221–227PubMed
115.
Srinivasan R, Asselin J, Gildengorin G et al (2009) A prospective study of ventilator-associated pneumonia in children. Pediatrics 123:1108–1115PubMed
116.
Subirana M, Sola I, Benito S (2007) Closed tracheal suction systems versus open tracheal suction systems for mechanically ventilated adult patients. Cochrane Database Syst Rev 4:CD004581PubMed
117.
Taira BR, Fenton KE, Lee TK et al (2009) Ventilator-associated pneumonia in pediatric trauma patients. Pediatr Crit Care Med 10:491–494PubMed
118.
Thill PJ, Mcguire JK, Baden HP et al (2004) Noninvasive positive-pressure ventilation in children with lower airway obstruction. Pediatr Crit Care Med 5:337–342PubMed
119.
Thorburn K (2009) Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection. Arch Dis Child 94:99–103PubMed
120.
Thorburn K, Kerr S, Taylor N et al (2004) RSV outbreak in a paediatric intensive care unit. J Hosp Infect 57:194–201PubMed
121.
Toltzis P (2004) Antibiotic-resistant gram-negative bacteria in hospitalized children. Clin Lab Med 24:363–380PubMed
122.
Toltzis P, Dul M, O’Riordan MA et al (2009) Meropenem use and colonization by antibiotic-resistant gram-negative bacilli in a pediatric intensive care unit. Pediatr Crit Care Med 10:49–54PubMed
123.
Torres A, Ewig S, Lode H et al (2009) Defining, treating and preventing hospital acquired pneumonia: European perspective. Intensive Care Med 35:9–29PubMed
124.
Trautmann M, Lepper PM, Haller M (2005) Ecology of Pseudomonas aeruginosa in the intensive care unit and the evolving role of water outlets as a reservoir of the organism. Am J Infect Control 33:S41–S49PubMed
125.
Trautmann M, Halder S, Hoegel J et al (2008) Point-of-use water filtration reduces endemic Pseudomonas aeruginosa infections on a surgical intensive care unit. Am J Infect Control 36:421–429PubMed
126.
Turton P (2008) Ventilator-associated pneumonia in paediatric intensive care: a literature review. Nurs Crit Care 13:241–248PubMed
127.
Van Der Wal J, Van Heerde M, Markhorst DG et al (2010) Transfusion of leukocyte-depleted red blood cells is not a risk factor for nosocomial infections in critically ill children. Pediatr Crit Care Med Nov 4. [Epub ahead of print]
128.
Voelz A, Muller A, Gillen J et al (2010) Outbreaks of Serratia marcescens in neonatal and pediatric intensive care units: clinical aspects, risk factors and management. Int J Hyg Environ Health 213(2):79–87PubMed
129.
Walsh TJ, Anaissie EJ, Denning DW et al (2008) Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 46:327–360PubMed
130.
Weber T, Salvi N, Orliaguet G et al (2009) Cuffed vs non-cuffed endotracheal tubes for pediatric anesthesia. Paediatr Anaesth [Suppl 1] 19:46–54
131.
Weiss M, Dullenkopf A (2007) Cuffed tracheal tubes in children: past, present and future. Expert Rev Med Devices 4:73–82PubMed
132.
White M, Barron J, Gornbein J et al (2010) Are red blood cell transfusions associated with nosocomial infections in pediatric intensive care units? Pediatr Crit Care Med 11:464–468PubMed
133.
Wright ML, Romano MJ (2006) Ventilator-associated pneumonia in children. Semin Pediatr Infect Dis 17:58–64PubMed
134.
Yanez LJ, Yunge M, Emilfork M et al (2008) A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure. Pediatr Crit Care Med 9:484–489PubMed
135.
Yildizdas D, Yapicioglu H, Yilmaz HL (2002) Occurrence of ventilator-associated pneumonia in mechanically ventilated pediatric intensive care patients during stress ulcer prophylaxis with sucralfate, ranitidine, and omeprazole. J Crit Care 17:240–245PubMed
136.
Zar HJ, Cotton MF (2002) Nosocomial pneumonia in pediatric patients: practical problems and rational solutions. Paediatr Drugs 4:73–83PubMed
Metadaten
Titel
Beatmungsassoziierte Pneumonie bei Kindern
verfasst von
PD. Dr. A. Simon
E. Tutdibi
L. von Müller
L. Gortner
Publikationsdatum
01.03.2011
Verlag
Springer-Verlag
Erschienen in
Monatsschrift Kinderheilkunde / Ausgabe 3/2011
Print ISSN: 0026-9298
Elektronische ISSN: 1433-0474
DOI
https://doi.org/10.1007/s00112-010-2303-4

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