nach oben

Intensive Care Medicine

Erschienen in:

01.10.2004 | Clinical Commentary

Acute renal failure is not a “cute” renal failure!

verfasst von: Wilfred Druml

Erschienen in: Intensive Care Medicine | Ausgabe 10/2004

Einloggen, um Zugang zu erhalten

Excerpt

There is a widely held and an insistent believe within the intensive care community that, because renal function can easily and practically indefinitely be replaced by modern renal replacement modalities, acute renal failure (ARF) presents a rather harmless complication, and that survival is determined by the severity of the underlying disease process/accompanying complications but not by renal dysfunction per se. This opinion is in sharp contrast to evidence from several recent experimental and clinical investigations indicating that ARF presents a condition which exerts a fundamental impact on the course of disease, the evolution of associated complications and on prognosis, independently from the type and severity of the underlying disease. …

Levy EM, Viscoli CM, Horwitz RI (1996) The effect of acute renal failure on mortality. A cohort analysis. JAMA 275:1489–1494PubMed

Chertow GM, Levy EM, Hammermeister KE, Grover F, Daley J (1998) Independent association between acute renal failure and mortality following cardiac surgery. Am J Med 104:343–348PubMed

Metnitz PG, Krenn CG, Steltzer H, Lang T, Ploder J, Lenz K, Le Gall JR, Druml W (2002) Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 30:2051–2058

Kellum JA, Angus DC (2002) Patients are dying of acute renal failure. Crit Care Med 30:2156–2157CrossRefPubMed

Rabb H, Daniels F, O’Donnell M, Haq M, Saba SR, Keane W, Tang WW (2000) Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in mice. Am J Physiol Renal Physiol 279:F525–531PubMed

Kramer AA, Postler G, Salhab KF, Mendez C, Carey LC, Rabb H (1999) Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kidney Int 55:2362–2367CrossRefPubMed

Yokota N, Daniels F, Crosson J, Rabb H (2002) Protective effect of T cell depletion in murine renal ischemia-reperfusion injury. Transplantation 74:759–763CrossRefPubMed

Harper SJ, Tomson CR, Bates DO (2002) Human uremic plasma increases microvascular permeability to water and proteins in vivo. Kidney Int 61:1416–1422CrossRefPubMed

Kelly KJ (2003) Distant effects of experimental renal ischemia/reperfusion injury. J Am Soc Nephrol 14:1549–1558PubMed

10.

Meldrum KK, Meldrum DR, Meng X, Ao L, Harken AH (2002) TNF-alpha-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion. Am J Physiol Heart Circ Physiol 282:H540–546PubMed

11.

Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, Marshall JC, Ranieri VM, Slutsky AS (2003) Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA 289:2104–2112CrossRefPubMed

12.

Suter PM (2002) MV causes lung inflammation and systemic immune depression. A balance of fire and ice. Intensive Care Med 28:383–385PubMed

13.

Gormley SM, McBride WT, Armstrong MA, McClean E, MacGowan SW, Campalani G, McMurray TJ (2002) Plasma and urinary cytokine homeostasis and renal function during cardiac surgery without cardiopulmonary bypass. Cytokine 17:61–65CrossRefPubMed

14.

Haag-Weber M, Horl WH (1996) Dysfunction of polymorphonuclear leukocytes in uremia. Semin Nephrol 16:192–201PubMed

15.

Cohen G, Haag-Weber M, Horl WH (1997) Immune dysfunction in uremia. Kidney Int Suppl 62:S79–82PubMed

16.

Druml W (2001) Nutritional management of acute renal failure. Am J Kidney Dis 37:S89–94PubMed

17.

Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P (2003) Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 31:359–366PubMed

18.

Woodrow G, Turney JH (1992) Cause of death in acute renal failure. Nephrol Dial Transplant 7:230–234PubMed

19.

Cook D, Heyland D, Griffith L, Cook R, Marshall J, Pagliarello J (1999) Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med 27:2812–2817

20.

Fiaccadori E, Maggiore U, Clima B, Melfa L, Rotelli C, Borghetti A (2001) Incidence, risk factors and prognosis of gastrointestinal hemorrhage complicating acute renal failure. Kidney Int 59:1510–1519CrossRefPubMed

21.

Druml W (1999) Metabolic aspects of continuous renal replacement therapies. Kidney Int Suppl 72:S56–61PubMed

22.

Metnitz GH, Fischer M, Bartens C, Steltzer H, Lang T, Druml W (2000) Impact of acute renal failure on antioxidant status in multiple organ failure. Acta Anaesthesiol Scand 44:236–240CrossRefPubMed

23.

Vogt B, Ferrari P, Schonholzer C, Marti HP, Mohaupt M, Wiederkehr M, Cereghetti C, Serra A, Huynh-Do U, Uehlinger D, Frey FJ (2001) Prophylactic hemodialysis after radiocontrast media in patients with renal insufficiency is potentially harmful. Am J Med 111:692–698PubMed

24.

Fissell WH, Lou L, Abrishami S, Buffington DA, Humes HD (2003) Bioartificial kidney ameliorates gram-negative bacteria-induced septic shock in uremic animals. J Am Soc Nephrol 14:454–461PubMed

25.

Gettings LG, Reynolds HN, Scalea T (1999) Outcome in post-traumatic acute renal failure when continuous renal replacement therapy is applied early vs. late. Intensive Care Med 25:805–813PubMed

26.

Ronco C, Bellomo R, Homel P, Brendolan A, Dan M, Piccinni P, La Greca G (2000) Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure: a prospective randomised trial. Lancet 356:26–30PubMed

27.

Bouman CS, Oudemans-Van Straaten HM, Tijssen JG, Zandstra DF, Kesecioglu J (2002) Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial. Crit Care Med 30:2205–2211CrossRefPubMed

28.

Evanson JA, Ikizler TA, Wingard R, Knights S, Shyr Y, Schulman G, Himmelfarb J, Hakim RM (1999) Measurement of the delivery of dialysis in acute renal failure. Kidney Int 55:1501–1508CrossRefPubMed

29.

Schiffl H, Lang SM, Fischer R (2002) Daily hemodialysis and the outcome of acute renal failure. N Engl J Med 346:305–310

Titel: Acute renal failure is not a “cute” renal failure!
verfasst von: Wilfred Druml
Publikationsdatum: 01.10.2004
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 10/2004
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2344-z

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren

Springer Medizin

Acute renal failure is not a “cute” renal failure!

Excerpt

Neu im Fachgebiet AINS

Sechs Maßnahmen gegen Regelschmerzen – von Krafttraining bis Yoga

Hereditäres Angioödem: Tablette könnte Akuttherapie erleichtern

Intoxikation ohne Alkoholaufnahme: An das Eigenbrauer-Syndrom denken!

Mit dem Seitenschneider gegen das Reißverschluss-Malheur

Update AINS

Springer Medizin

Excerpt

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2004

Induced hypothermia in traumatic brain injury: considering the conflicting results of meta-analyses and moving forward

Beneficial effect of low-molecular-weight heparin against lipopolysaccharide-induced disseminated intravascular coagulation in rats is abolished by coadministration of tranexamic acid

Two cases of acute respiratory failure due to carcinomatous lymphangitis in HIV patients

Benefits of minocycline and rifampin-impregnated central venous catheters

Recovery from lung injury in survivors of acute respiratory distress syndrome: difference between pulmonary and extrapulmonary subtypes

Faucets as a reservoir of endemic Pseudomonas aeruginosa colonization/infections in intensive care units

Neu im Fachgebiet AINS

Sechs Maßnahmen gegen Regelschmerzen – von Krafttraining bis Yoga

Hereditäres Angioödem: Tablette könnte Akuttherapie erleichtern

Intoxikation ohne Alkoholaufnahme: An das Eigenbrauer-Syndrom denken!

Mit dem Seitenschneider gegen das Reißverschluss-Malheur

Update AINS