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Erschienen in:
01.06.2010 | Original
Pharmacokinetics of moxifloxacin in patients with severe sepsis or septic shock
Erschienen in: Intensive Care Medicine | Ausgabe 6/2010
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Purpose
To investigate the steady-state pharmacokinetics of moxifloxacin in critically ill patients after intravenous administration of the 400 mg fixed dose.
Methods
Fifteen adult patients with severe sepsis (n = 3) or septic shock (n = 12) were enrolled in this dual-centre, prospective, open-label study. Moxifloxacin was administered with the recommended dose of 400 mg once daily i.v. for at least 5 days. Blood samples were obtained before and 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 18 and 24 h after the third administration. Moxifloxacin concentrations in plasma were measured by HPLC with fluorescence detection.
Results
Data for 400 mg moxifloxacin i.v. were as follows (geometric mean): C
max: 3.5 mg/l, t
½: 7.8 h and AUC (48–72 h): 25 mg h/l. In five individual patients AUC (48–72 h) was <20 mg h/l.
Conclusion
The main pharmacokinetics/pharmacodynamics parameter predicting clinical efficacy of moxifloxacin is AUC/MIC. The mean AUC of patients with severe sepsis or septic shock was lower compared to healthy volunteers (39 mg h/l). In 5 of 12 patients the AUC was halved compared to healthy volunteers.