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Erschienen in: Neuroradiology 2/2008

01.02.2008 | Diagnostic Neuroradiology

Clinical applications of susceptibility weighted MR imaging of the brain – a pictorial review

verfasst von: Bejoy Thomas, Sivaraman Somasundaram, Krishnamoorthy Thamburaj, Chandrasekharan Kesavadas, Arun Kumar Gupta, Narendra K. Bodhey, Tirur Raman Kapilamoorthy

Erschienen in: Neuroradiology | Ausgabe 2/2008

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Abstract

Introduction

Susceptibility-weighted imaging (SWI) is a novel magnetic resonance (MR) technique that exploits the magnetic susceptibility differences of various tissues, such as blood, iron and calcification. This pictorial review covers many clinical conditions illustrating its usefulness.

Methods

SWI consists of using both magnitude and phase images from a high-resolution, three-dimensional fully velocity-compensated gradient echo sequence. Phase mask is created from the MR phase images, and multiplying these with the magnitude images increase the conspicuity of the smaller veins and other sources of susceptibility effects, which is depicted using minimal intensity projection (minIP).

Results

The phase images are useful in differentiating between diamagnetic and paramagnetic susceptibility effects of calcium and blood, respectively. This unique MR sequence will help in detecting occult low flow vascular lesions, calcification and cerebral microbleed in various pathologic conditions and aids in characterizing tumors and degenerative diseases of the brain. This sequence also can be used to visualize normal brain structures with conspicuity.

Conclusion

Susceptibility-weighted imaging is useful in differentiating and characterizing diverse brain pathologies.
Literatur
1.
Zurück zum Zitat Reichenbach JR, Venkatesan R, Schillinger DJ et al (1997) Small vessels in the human brain. MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology 204:272–277PubMed Reichenbach JR, Venkatesan R, Schillinger DJ et al (1997) Small vessels in the human brain. MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology 204:272–277PubMed
2.
Zurück zum Zitat Reichenbach JR, Haacke EM (2001) High-resolution BOLD venographic imaging: a window into brain function. NMR Biomed 14:453–467PubMedCrossRef Reichenbach JR, Haacke EM (2001) High-resolution BOLD venographic imaging: a window into brain function. NMR Biomed 14:453–467PubMedCrossRef
3.
Zurück zum Zitat Seghal V, Delproposto Z, Haacke EM et al (2005) Clinical application s of neuroimaging with susceptibility-weighted imaging. J Magn Reson Imaging 22:439–450CrossRef Seghal V, Delproposto Z, Haacke EM et al (2005) Clinical application s of neuroimaging with susceptibility-weighted imaging. J Magn Reson Imaging 22:439–450CrossRef
4.
Zurück zum Zitat Liang L, Korogi Y, Sugahara T, Shigematsu Y, Okuda T, Ikushima I, Takahashi M (1999) Detection of intracranial hemorrhage with susceptibility-weighted MR sequences. AJNR Am J Neuroradiol 20:1527–1534PubMed Liang L, Korogi Y, Sugahara T, Shigematsu Y, Okuda T, Ikushima I, Takahashi M (1999) Detection of intracranial hemorrhage with susceptibility-weighted MR sequences. AJNR Am J Neuroradiol 20:1527–1534PubMed
5.
Zurück zum Zitat Wang Y, Yu Y, Li D et al (2000) Artery and vein separation using susceptibility-dependent phase in contrast enhanced MRA. J Magn Reson Imaging 12:661–670PubMedCrossRef Wang Y, Yu Y, Li D et al (2000) Artery and vein separation using susceptibility-dependent phase in contrast enhanced MRA. J Magn Reson Imaging 12:661–670PubMedCrossRef
6.
Zurück zum Zitat Rauscher A, Sedlacik J, Barth M, Haacke EM, Reichenbach JR et al (2005) Magnetic susceptibility-weighted MR phase imaging of the human brain. AJNR Am J Neroradiol 26:736–742 Rauscher A, Sedlacik J, Barth M, Haacke EM, Reichenbach JR et al (2005) Magnetic susceptibility-weighted MR phase imaging of the human brain. AJNR Am J Neroradiol 26:736–742
7.
Zurück zum Zitat Yamada N, Imakita S, Sakuma T et al (1996) Intracranial calcification on gradient -echo phase image:Depiction of Diamagnetic susceptibility. Radiology 198:171–178 Yamada N, Imakita S, Sakuma T et al (1996) Intracranial calcification on gradient -echo phase image:Depiction of Diamagnetic susceptibility. Radiology 198:171–178
8.
Zurück zum Zitat Gupta RK, Rao SB, Rajan J et al (2001) Differentiation of calcification from chronic hemorrhage with corrected gradient echo phase imaging. J Comput Assist Tomogr 25:698–704PubMedCrossRef Gupta RK, Rao SB, Rajan J et al (2001) Differentiation of calcification from chronic hemorrhage with corrected gradient echo phase imaging. J Comput Assist Tomogr 25:698–704PubMedCrossRef
9.
Zurück zum Zitat Yamada N, Imakita S, Sakuma T et al (1990) Evaluation of the susceptibility effect on the phase images of a simple gradient echo. Radiology 175:561–565PubMed Yamada N, Imakita S, Sakuma T et al (1990) Evaluation of the susceptibility effect on the phase images of a simple gradient echo. Radiology 175:561–565PubMed
10.
Zurück zum Zitat Deistung A, Mentzel HJ, Rauscher A, Witoszynskyj S, Kaiser WA, Reichenbach JR (2006) Demonstration of paramagnetic and diamagnetic cerebral lesions by using susceptibility weighted phase imaging (SWI). Z Med Phys 16:261–267PubMed Deistung A, Mentzel HJ, Rauscher A, Witoszynskyj S, Kaiser WA, Reichenbach JR (2006) Demonstration of paramagnetic and diamagnetic cerebral lesions by using susceptibility weighted phase imaging (SWI). Z Med Phys 16:261–267PubMed
11.
Zurück zum Zitat Dumoulin CL, Hart HJ (1986) Magnetic resonance angiography. Radiology 161:717–720PubMed Dumoulin CL, Hart HJ (1986) Magnetic resonance angiography. Radiology 161:717–720PubMed
12.
Zurück zum Zitat Thulborn KR, Waterton JC, Matthews PM et al (1982) Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 714:265–270PubMed Thulborn KR, Waterton JC, Matthews PM et al (1982) Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta 714:265–270PubMed
13.
Zurück zum Zitat Li D, Waight DJ, Wang Y (1998) In vivo correlation between blood T2* and oxygen saturation. J Magn Reson Imaging 8:1236–1239PubMedCrossRef Li D, Waight DJ, Wang Y (1998) In vivo correlation between blood T2* and oxygen saturation. J Magn Reson Imaging 8:1236–1239PubMedCrossRef
14.
Zurück zum Zitat Gomori JM, Grossman RI, Yu-Ip C et al (1987) NMR relaxation times of blood: dependence on field strength, oxidation state, and cell integrity. J Comput Assist Tomogr 11:684–690PubMedCrossRef Gomori JM, Grossman RI, Yu-Ip C et al (1987) NMR relaxation times of blood: dependence on field strength, oxidation state, and cell integrity. J Comput Assist Tomogr 11:684–690PubMedCrossRef
15.
Zurück zum Zitat Haacke EM, Satin W (1993) Fast imaging and vessel contrast. In: Potchen EJ, Haacke EM, Siebert JE, Gottaschalk A (eds) Magneticresonanceangiography. Mosby, St. Louis, pp 46–51 Haacke EM, Satin W (1993) Fast imaging and vessel contrast. In: Potchen EJ, Haacke EM, Siebert JE, Gottaschalk A (eds) Magneticresonanceangiography. Mosby, St. Louis, pp 46–51
16.
Zurück zum Zitat Reichenbach JR, Venkatesan R, Yablonsky DA et al (1997) Theory and application of static field inhomogenity effects inn gradient echo imaging. J Magn Reson Imaging 7:266–279PubMedCrossRef Reichenbach JR, Venkatesan R, Yablonsky DA et al (1997) Theory and application of static field inhomogenity effects inn gradient echo imaging. J Magn Reson Imaging 7:266–279PubMedCrossRef
17.
Zurück zum Zitat Lee BCP, Vo KD, Kido DK et al (1999) MR high resolution blood oxygenation level dependent venography of occult (low-flow) vascular lesions. AJNR Am J Neuroradiol 20:1239–1242PubMed Lee BCP, Vo KD, Kido DK et al (1999) MR high resolution blood oxygenation level dependent venography of occult (low-flow) vascular lesions. AJNR Am J Neuroradiol 20:1239–1242PubMed
18.
Zurück zum Zitat Reichenbach JR, Jonetz-Mentzel L, Fitzek C et al (2001) High resolution blood oxygen-level dependent MR venography. Neuroradiology 43:364–369PubMedCrossRef Reichenbach JR, Jonetz-Mentzel L, Fitzek C et al (2001) High resolution blood oxygen-level dependent MR venography. Neuroradiology 43:364–369PubMedCrossRef
19.
Zurück zum Zitat Essig M, Reichenbach JR, Schad JR et al (1999) High resolution MR venography of cerebral arteriovenous malformations. Magn Reson Imaging 17:1417–1425PubMedCrossRef Essig M, Reichenbach JR, Schad JR et al (1999) High resolution MR venography of cerebral arteriovenous malformations. Magn Reson Imaging 17:1417–1425PubMedCrossRef
20.
Zurück zum Zitat Lin W, Mukherjee P, An H et al (1999) Improving high resolution MR bold venographic imaging using a T1 reducing contrast agent. J Magn Reson Imaging 10:118–123PubMedCrossRef Lin W, Mukherjee P, An H et al (1999) Improving high resolution MR bold venographic imaging using a T1 reducing contrast agent. J Magn Reson Imaging 10:118–123PubMedCrossRef
21.
Zurück zum Zitat Dean Bl, Drayer BP, Bird CR, Flora RA, Hodak JA, Coons SW, Carey RG (1990) Gliomas:classification with MR imaging. Radiology 174:411–415 Dean Bl, Drayer BP, Bird CR, Flora RA, Hodak JA, Coons SW, Carey RG (1990) Gliomas:classification with MR imaging. Radiology 174:411–415
22.
Zurück zum Zitat Ding B, Ling HW, Chen KM, Jiang H, Zhu YB (2006) Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging. Neuroradiology 48:773–781PubMedCrossRef Ding B, Ling HW, Chen KM, Jiang H, Zhu YB (2006) Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging. Neuroradiology 48:773–781PubMedCrossRef
23.
Zurück zum Zitat Recht L, Torres CO, Smith TW et al (1990) Transferrin receptor in normal and neoplastic brain tissue :implications for brain tumor immunotherapy. J Neurosurg 72:941–945PubMed Recht L, Torres CO, Smith TW et al (1990) Transferrin receptor in normal and neoplastic brain tissue :implications for brain tumor immunotherapy. J Neurosurg 72:941–945PubMed
24.
Zurück zum Zitat Bagley L, Grossman RI, Judy KD et al (1997) Gliomas: correlation of magnetic susceptibility artifact with histologic grade. Radiology 202:511–516PubMed Bagley L, Grossman RI, Judy KD et al (1997) Gliomas: correlation of magnetic susceptibility artifact with histologic grade. Radiology 202:511–516PubMed
25.
Zurück zum Zitat Seghal V, Delproposto Z, Haddar D et al (2006) Susceptibility-weighted imaging to visualise blood products and improve tumor contrast in the study of brain masses. J Magn Reson Imaging 24:41–51CrossRef Seghal V, Delproposto Z, Haddar D et al (2006) Susceptibility-weighted imaging to visualise blood products and improve tumor contrast in the study of brain masses. J Magn Reson Imaging 24:41–51CrossRef
26.
Zurück zum Zitat Christoforidis GA, Kangarlu A, Abduljalil AM et al (2004) Susceptibility-based imaging of glioblastoma Microvascularity at 8T.: correlation of MR imaging and postmortem pathology. AJNR Am J Neuroradiol 25:756–760PubMed Christoforidis GA, Kangarlu A, Abduljalil AM et al (2004) Susceptibility-based imaging of glioblastoma Microvascularity at 8T.: correlation of MR imaging and postmortem pathology. AJNR Am J Neuroradiol 25:756–760PubMed
27.
Zurück zum Zitat Krishnamoorthy T, Radhakrishnan VV, Thomas B et al (2006) Microhemorrhages in vestibular schwannomas: prospective study with T2* weighted gradient-echo sequence. In: Proc Am Soc Neurorad (ASNR). San Diego, USA Krishnamoorthy T, Radhakrishnan VV, Thomas B et al (2006) Microhemorrhages in vestibular schwannomas: prospective study with T2* weighted gradient-echo sequence. In: Proc Am Soc Neurorad (ASNR). San Diego, USA
28.
Zurück zum Zitat Wardlaw JM, Statham PF (2000) How often is haemosiderin not visible on routine MRI following traumatic intracerebral haemorrhage? Neuroradiology 42:81–84PubMedCrossRef Wardlaw JM, Statham PF (2000) How often is haemosiderin not visible on routine MRI following traumatic intracerebral haemorrhage? Neuroradiology 42:81–84PubMedCrossRef
29.
Zurück zum Zitat Gentry LR, Godersky JC, Thompsonn B (1988) MR imaging of head trauma:review of the distribution and radiopathologic features of traumatic lesions. AJR Am J Roentgenol 150:663–672PubMed Gentry LR, Godersky JC, Thompsonn B (1988) MR imaging of head trauma:review of the distribution and radiopathologic features of traumatic lesions. AJR Am J Roentgenol 150:663–672PubMed
30.
Zurück zum Zitat Medana IM, Esiri MM (2003) Axonal damage: a key predictor of outcome in human CNS diseases. Brain 126:515–530PubMedCrossRef Medana IM, Esiri MM (2003) Axonal damage: a key predictor of outcome in human CNS diseases. Brain 126:515–530PubMedCrossRef
31.
Zurück zum Zitat Orrison WW, Gentry LR, Stimac GK et al (1994) Blinded comparison of cranial CT and MR in closed head injury evaluation. AJNR Am J Neuroradiology 15:351–356 Orrison WW, Gentry LR, Stimac GK et al (1994) Blinded comparison of cranial CT and MR in closed head injury evaluation. AJNR Am J Neuroradiology 15:351–356
32.
Zurück zum Zitat Paterakis K, Karantanas AH, Komnos A et al (2000) Outcome of patients with diffuse axonal injury: the significance and prognostic value of MRI in the acute phase. J Trauma 49:1071–1075PubMedCrossRef Paterakis K, Karantanas AH, Komnos A et al (2000) Outcome of patients with diffuse axonal injury: the significance and prognostic value of MRI in the acute phase. J Trauma 49:1071–1075PubMedCrossRef
33.
Zurück zum Zitat Atlas SW, Mark AS, Grossman RI et al (1988) Intracranial Hemorrhage: gradient echo MR imaging at 1.5 T.-comparison with spin echo imaging and clinical applications. Radiology 168:803–807PubMed Atlas SW, Mark AS, Grossman RI et al (1988) Intracranial Hemorrhage: gradient echo MR imaging at 1.5 T.-comparison with spin echo imaging and clinical applications. Radiology 168:803–807PubMed
34.
Zurück zum Zitat Tong KA, Ashwal S, Holshouer B et al (2003) Hemorrhagic shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results. Radiology 227:332–339PubMedCrossRef Tong KA, Ashwal S, Holshouer B et al (2003) Hemorrhagic shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results. Radiology 227:332–339PubMedCrossRef
35.
Zurück zum Zitat Wycliffe ND, Chose J, Holshouser B et al (2004) Reliability in detection of hemorrhage in acute stroke by a new three-dimensional gradient recalled echo susceptibility-weighted imaging technique compared to computed tomography: a retrospective study. J Magn Reson Imaging 20:372–377PubMedCrossRef Wycliffe ND, Chose J, Holshouser B et al (2004) Reliability in detection of hemorrhage in acute stroke by a new three-dimensional gradient recalled echo susceptibility-weighted imaging technique compared to computed tomography: a retrospective study. J Magn Reson Imaging 20:372–377PubMedCrossRef
37.
Zurück zum Zitat Kidwell CS, Saver JL, Villablanca JP et al (2002) Magnetic resonance imaging detection of microbleeds before thrombolysis:an emerging application. Stroke 33:95–98PubMedCrossRef Kidwell CS, Saver JL, Villablanca JP et al (2002) Magnetic resonance imaging detection of microbleeds before thrombolysis:an emerging application. Stroke 33:95–98PubMedCrossRef
38.
Zurück zum Zitat Greenberg SM, O’Donnel HC, Schaefer PW et al (1999) MRI detection of new hemorrhages:potential marker of progression in cerebral amyloid angiopathy. Neurology 53:1135–1138PubMed Greenberg SM, O’Donnel HC, Schaefer PW et al (1999) MRI detection of new hemorrhages:potential marker of progression in cerebral amyloid angiopathy. Neurology 53:1135–1138PubMed
39.
Zurück zum Zitat Lesnik OAJ, Van Den Boom R, Van buchem A et al (2001) Cerebral microbleeds in CADASIL. Neurology 57:1066–1070 Lesnik OAJ, Van Den Boom R, Van buchem A et al (2001) Cerebral microbleeds in CADASIL. Neurology 57:1066–1070
40.
Zurück zum Zitat Martin D, Makus H, Jurgen H et al (2002) Cerebral microbleeds in CADASIL: a gradient echo MRI and autopsy study. Stroke 33:67–71CrossRef Martin D, Makus H, Jurgen H et al (2002) Cerebral microbleeds in CADASIL: a gradient echo MRI and autopsy study. Stroke 33:67–71CrossRef
41.
Zurück zum Zitat Campi A, Benndorf G, Filippi M, Reganati P, Martinelli V, Terreni MR (2001) Primary angiitis of the central nervous system: serial MRI of brain and spinal cord. Neuroradiology 43:599–607PubMedCrossRef Campi A, Benndorf G, Filippi M, Reganati P, Martinelli V, Terreni MR (2001) Primary angiitis of the central nervous system: serial MRI of brain and spinal cord. Neuroradiology 43:599–607PubMedCrossRef
42.
Zurück zum Zitat Gerrnberg SM, Finklestein SP, Schaefer et al (1996) Petechial hemorrhages accompanying lobar hemorrhage:detection by gradient echo MRI. Neurology 46:1751–1754 Gerrnberg SM, Finklestein SP, Schaefer et al (1996) Petechial hemorrhages accompanying lobar hemorrhage:detection by gradient echo MRI. Neurology 46:1751–1754
43.
Zurück zum Zitat Bartzokis G, Tishler TA (2000) MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimers and huntingtons disease. Cell Mol Biol 46:821–833 Bartzokis G, Tishler TA (2000) MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimers and huntingtons disease. Cell Mol Biol 46:821–833
44.
Zurück zum Zitat Bartzokis G, Cummins J, Markham Ch et al (1999) MRI evaluation of brain iron in earlier and later onset Parkinsons disease and normal subjects. Magn Reson Imaging 17:213–222PubMedCrossRef Bartzokis G, Cummins J, Markham Ch et al (1999) MRI evaluation of brain iron in earlier and later onset Parkinsons disease and normal subjects. Magn Reson Imaging 17:213–222PubMedCrossRef
45.
Zurück zum Zitat Hecht MJ, Fellner C, Schmid A, Neundorfer B, Fellner FA (2005) Cortical T2 signal shortening in amyotrophic lateral sclerosis is not due to iron deposits. Neuroradiology 47:805–808PubMedCrossRef Hecht MJ, Fellner C, Schmid A, Neundorfer B, Fellner FA (2005) Cortical T2 signal shortening in amyotrophic lateral sclerosis is not due to iron deposits. Neuroradiology 47:805–808PubMedCrossRef
46.
Zurück zum Zitat Vymazal J, Righini A, Brooks RA et al (1999) T1 and T2 in the brain of healthy subjects,patients with Parkinson disease and patients with multiple system atrophy: relation to iron content. Radiology 211:489–495PubMed Vymazal J, Righini A, Brooks RA et al (1999) T1 and T2 in the brain of healthy subjects,patients with Parkinson disease and patients with multiple system atrophy: relation to iron content. Radiology 211:489–495PubMed
47.
Zurück zum Zitat Ogg RJ, Langston JW, Haacke EM et al (1999) The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 17:1141–1148PubMedCrossRef Ogg RJ, Langston JW, Haacke EM et al (1999) The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 17:1141–1148PubMedCrossRef
48.
Zurück zum Zitat Haacke EM, Ayaz M, Khan A, Manova ES, Krishnamurthy B, Gollapalli L, Ciulla C, Kim I, Petersen F, Kirsch W (2007) Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging 26:256–264PubMedCrossRef Haacke EM, Ayaz M, Khan A, Manova ES, Krishnamurthy B, Gollapalli L, Ciulla C, Kim I, Petersen F, Kirsch W (2007) Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging 26:256–264PubMedCrossRef
49.
Zurück zum Zitat Tan IL, van Schijndel RA, Pouwels PJ, van Walderveen MA, Reichenbach JR, Manoliu RA, Barkhof F (2000) MR venography of multiple sclerosis. AJNR Am J Neuroradiol 21:1039–1042PubMed Tan IL, van Schijndel RA, Pouwels PJ, van Walderveen MA, Reichenbach JR, Manoliu RA, Barkhof F (2000) MR venography of multiple sclerosis. AJNR Am J Neuroradiol 21:1039–1042PubMed
50.
Zurück zum Zitat Reichenbach JR, Barth M, Haacke M et al (2000) High-resolution MR venography at 3.0 tesla. J Comput Assist Tomogr 24:949–957PubMedCrossRef Reichenbach JR, Barth M, Haacke M et al (2000) High-resolution MR venography at 3.0 tesla. J Comput Assist Tomogr 24:949–957PubMedCrossRef
Metadaten
Titel
Clinical applications of susceptibility weighted MR imaging of the brain – a pictorial review
verfasst von
Bejoy Thomas
Sivaraman Somasundaram
Krishnamoorthy Thamburaj
Chandrasekharan Kesavadas
Arun Kumar Gupta
Narendra K. Bodhey
Tirur Raman Kapilamoorthy
Publikationsdatum
01.02.2008
Verlag
Springer-Verlag
Erschienen in
Neuroradiology / Ausgabe 2/2008
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-007-0316-z

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