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Erschienen in: Skeletal Radiology 12/2019

15.07.2019 | Review Article

The Dixon technique for MRI of the bone marrow

verfasst von: Niels van Vucht, Rodney Santiago, Bianca Lottmann, Ian Pressney, Dorothee Harder, Adnan Sheikh, Asif Saifuddin

Erschienen in: Skeletal Radiology | Ausgabe 12/2019

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Abstract

Dixon sequences are established as a reliable MRI technique that can be used for problem-solving in the assessment of bone marrow lesions. Unlike other fat suppression methods, Dixon techniques rely on the difference in resonance frequency between fat and water and in a single acquisition, fat only, water only, in-phase and out-of-phase images are acquired. This gives Dixon techniques the unique ability to quantify the amount of fat within a bone lesion, allowing discrimination between marrow-infiltrating and non-marrow-infiltrating lesions such as focal nodular marrow hyperplasia. Dixon can be used with gradient echo and spin echo techniques, both two-dimensional and three-dimensional imaging. Another advantage is its rapid acquisition time, especially when using traditional two-point Dixon gradient echo sequences. Overall, Dixon is a robust fat suppression method that can also be used with intravenous contrast agents. After reviewing the available literature, we would like to advocate the implementation of additional Dixon sequences as a problem-solving tool during the assessment of bone marrow pathology.
Literatur
1.
Zurück zum Zitat Dixon WT. Simple proton spectroscopic imaging. Radiology. 1984;153(1):189–94.PubMed Dixon WT. Simple proton spectroscopic imaging. Radiology. 1984;153(1):189–94.PubMed
2.
Zurück zum Zitat Adam SZ, Nikolaidis P, Horowitz JM, Gabriel H, Hammond NA, Patel T, et al. Chemical shift MR imaging of the adrenal gland: principles, pitfalls, and applications. RadioGraphics. 2016;36(2):414–32.PubMed Adam SZ, Nikolaidis P, Horowitz JM, Gabriel H, Hammond NA, Patel T, et al. Chemical shift MR imaging of the adrenal gland: principles, pitfalls, and applications. RadioGraphics. 2016;36(2):414–32.PubMed
3.
Zurück zum Zitat Wismer GL, Rosen BR, Buxton R, Stark DD, Brady TJ. Chemical shift imaging of bone marrow: preliminary experience. Am J Roentgenol. 1985;145:1031–7. Wismer GL, Rosen BR, Buxton R, Stark DD, Brady TJ. Chemical shift imaging of bone marrow: preliminary experience. Am J Roentgenol. 1985;145:1031–7.
4.
Zurück zum Zitat Lefebvre G. One sequence, many benefits in musculoskeletal MRI. Fieldstrength. 2015:18–21. Lefebvre G. One sequence, many benefits in musculoskeletal MRI. Fieldstrength. 2015:18–21.
5.
Zurück zum Zitat Maeder Y, Dunet V, Richard R, Becce F, Omoumi P. Bone marrow metastases: T2-weighted Dixon spin-echo fat images can replace T1-weighted spin-echo images. Radiology. 2018;286(3):948–59.PubMed Maeder Y, Dunet V, Richard R, Becce F, Omoumi P. Bone marrow metastases: T2-weighted Dixon spin-echo fat images can replace T1-weighted spin-echo images. Radiology. 2018;286(3):948–59.PubMed
6.
Zurück zum Zitat Naraghi A, White LM. Three-dimensional MRI of the musculoskeletal system. Am J Roentgenol. 2012;199:283–93. Naraghi A, White LM. Three-dimensional MRI of the musculoskeletal system. Am J Roentgenol. 2012;199:283–93.
7.
Zurück zum Zitat Ma J. A single-point Dixon technique for fat-suppressed fast 3D gradient-echo imaging with a flexible echo time. J Magn Reson Imaging. 2008;27(4):881–90.PubMed Ma J. A single-point Dixon technique for fat-suppressed fast 3D gradient-echo imaging with a flexible echo time. J Magn Reson Imaging. 2008;27(4):881–90.PubMed
8.
Zurück zum Zitat Guerini H, Omoumi P, Guichoux F, Vuillemin V, Morvan G, Zins M, et al. Fat suppression with Dixon techniques in musculoskeletal magnetic resonance imaging: a pictorial review. Semin Musculoskelet Radiol. 2015:335–47. Guerini H, Omoumi P, Guichoux F, Vuillemin V, Morvan G, Zins M, et al. Fat suppression with Dixon techniques in musculoskeletal magnetic resonance imaging: a pictorial review. Semin Musculoskelet Radiol. 2015:335–47.
9.
Zurück zum Zitat Del Grande F, Santini F, Herzka DA, Aro MR, Dean CW, Gold GE, et al. Fat-suppression techniques for 3-T MR imaging of the musculoskeletal system. Radiographics. 2014;34(1):217–33.PubMed Del Grande F, Santini F, Herzka DA, Aro MR, Dean CW, Gold GE, et al. Fat-suppression techniques for 3-T MR imaging of the musculoskeletal system. Radiographics. 2014;34(1):217–33.PubMed
10.
Zurück zum Zitat Maas M, Dijkstra PF, Akkerman EM. Uniform fat suppression in hands and feet through the use of two-point Dixon chemical shift MR imaging. Radiology. 1999;210(1):189–93.PubMed Maas M, Dijkstra PF, Akkerman EM. Uniform fat suppression in hands and feet through the use of two-point Dixon chemical shift MR imaging. Radiology. 1999;210(1):189–93.PubMed
11.
Zurück zum Zitat Park HJ, Lee SY, Choi SH, Hong HP, Choi YJ, Kim MS. Reduced metallic artefacts in 3T knee MRI using fast spin-echo multi-point Dixon compared to fast spin-echo T2-weighted sequences. Clin Radiol. 2017;72(11):996.e1–6. Park HJ, Lee SY, Choi SH, Hong HP, Choi YJ, Kim MS. Reduced metallic artefacts in 3T knee MRI using fast spin-echo multi-point Dixon compared to fast spin-echo T2-weighted sequences. Clin Radiol. 2017;72(11):996.e1–6.
12.
Zurück zum Zitat Lee S, Choi D, Shin H, Baek H, Choi H, Park S. FSE T2-weighted two-point Dixon technique for fat suppression in the lumbar spine: comparison with SPAIR technique. Diagnostic Interv Radiol. 2018;24:175–80. Lee S, Choi D, Shin H, Baek H, Choi H, Park S. FSE T2-weighted two-point Dixon technique for fat suppression in the lumbar spine: comparison with SPAIR technique. Diagnostic Interv Radiol. 2018;24:175–80.
13.
Zurück zum Zitat Brandão S, Seixas D, Ayres-Basto M, Castro S, Neto J, Martin C, et al. Comparing T1-weighted and T2-weighted three-point Dixon technique with conventional T1-weighted fat-saturation and short-tau inversion recovery (STIR) techniques for the study of the lumbar spine in a short-bore MRI machine. Clin Radiol. 2013;68(11):e617–23.PubMed Brandão S, Seixas D, Ayres-Basto M, Castro S, Neto J, Martin C, et al. Comparing T1-weighted and T2-weighted three-point Dixon technique with conventional T1-weighted fat-saturation and short-tau inversion recovery (STIR) techniques for the study of the lumbar spine in a short-bore MRI machine. Clin Radiol. 2013;68(11):e617–23.PubMed
14.
Zurück zum Zitat Reeder SB, Yu H, Johnson JW, Shimakawa A, Brittain JH, Pelc NJ, et al. T1- and T2-weighted fast spin-echo imaging of the brachial plexus and cervical spine with IDEAL water–fat separation. J Magn Reson Imaging. 2006;24(4):825–32.PubMed Reeder SB, Yu H, Johnson JW, Shimakawa A, Brittain JH, Pelc NJ, et al. T1- and T2-weighted fast spin-echo imaging of the brachial plexus and cervical spine with IDEAL water–fat separation. J Magn Reson Imaging. 2006;24(4):825–32.PubMed
15.
Zurück zum Zitat Rybicki FJ, Chung T, Reid J, Jaramillo D, Mulkern RV, Ma J. Fast three-point Dixon MR imaging using low-resolution images for phase correction: a comparison with for pediatric musculoskeletal imaging. Am J Roentgenol. 2001;177:1019–23. Rybicki FJ, Chung T, Reid J, Jaramillo D, Mulkern RV, Ma J. Fast three-point Dixon MR imaging using low-resolution images for phase correction: a comparison with for pediatric musculoskeletal imaging. Am J Roentgenol. 2001;177:1019–23.
16.
Zurück zum Zitat Kirchgesner T, Perlepe V, Michoux N, Larbi A, Vande BB. Fat suppression at three-dimensional T1-weighted MR imaging of the hands: Dixon method versus CHESS technique. Diagn Interv Imaging. 2018;99:23–8.PubMed Kirchgesner T, Perlepe V, Michoux N, Larbi A, Vande BB. Fat suppression at three-dimensional T1-weighted MR imaging of the hands: Dixon method versus CHESS technique. Diagn Interv Imaging. 2018;99:23–8.PubMed
17.
Zurück zum Zitat Wehrli F, Perkins T, Shimakawa A, Roberts F. Chemical shift-induced amplitude modulations in images obtained with gradient refocusing. Magn Reson Imaging. 1987;5(2):157–8.PubMed Wehrli F, Perkins T, Shimakawa A, Roberts F. Chemical shift-induced amplitude modulations in images obtained with gradient refocusing. Magn Reson Imaging. 1987;5(2):157–8.PubMed
18.
Zurück zum Zitat Bley TA, Wieben O, François CJ, Brittain JH, Reeder SB. Fat and water magnetic resonance imaging. J Magn Reson Imaging. 2010;31(1):4–18.PubMed Bley TA, Wieben O, François CJ, Brittain JH, Reeder SB. Fat and water magnetic resonance imaging. J Magn Reson Imaging. 2010;31(1):4–18.PubMed
19.
Zurück zum Zitat Eggers H, Börnert P. Chemical shift encoding-based water-fat separation methods. J Magn Reson Imaging. 2014;40(2):251–68.PubMed Eggers H, Börnert P. Chemical shift encoding-based water-fat separation methods. J Magn Reson Imaging. 2014;40(2):251–68.PubMed
20.
Zurück zum Zitat Prince C, Oesingmann N, McGorty K, Lee V. Optimization of in-phase and opposed phase imaging at 3T for abdominal MRI. Proc Intl Soc Mag Reson Med. 2007;184(6):3837. Prince C, Oesingmann N, McGorty K, Lee V. Optimization of in-phase and opposed phase imaging at 3T for abdominal MRI. Proc Intl Soc Mag Reson Med. 2007;184(6):3837.
21.
Zurück zum Zitat Grimm A, Meyer H, Nickel MD, Nittka M, Raithel E, Chaudry O, et al. Evaluation of 2-point, 3-point, and 6-point Dixon magnetic resonance imaging with flexible echo timing for muscle fat quantification. Eur J Radiol. 2018;103:57–64.PubMed Grimm A, Meyer H, Nickel MD, Nittka M, Raithel E, Chaudry O, et al. Evaluation of 2-point, 3-point, and 6-point Dixon magnetic resonance imaging with flexible echo timing for muscle fat quantification. Eur J Radiol. 2018;103:57–64.PubMed
22.
Zurück zum Zitat Ma J, Son JB, Bankson JA, Stafford RJ, Choi H, Ragan D. A fast spin echo two-point Dixon technique and its combination with sensitivity encoding for efficient T2-weighted imaging. Magn Reson Imaging. 2005;23(10):977–82.PubMed Ma J, Son JB, Bankson JA, Stafford RJ, Choi H, Ragan D. A fast spin echo two-point Dixon technique and its combination with sensitivity encoding for efficient T2-weighted imaging. Magn Reson Imaging. 2005;23(10):977–82.PubMed
23.
Zurück zum Zitat Weishaupt D, Köchli VD, Marincek B. How does MRI work: an introduction to the physics and function of magnetic resonance imaging. 2nd edition. Berlin Heidelberg: Springer, 2008. Weishaupt D, Köchli VD, Marincek B. How does MRI work: an introduction to the physics and function of magnetic resonance imaging. 2nd edition. Berlin Heidelberg: Springer, 2008.
24.
Zurück zum Zitat Park H, Lee SY, Rho MH, Chung EC, Ahn JH, Park JH, et al. Usefulness of the fast spin-echo three-point Dixon (mDixon) image of the knee joint on 3.0T MRI: comparison with conventional fast spin-echo T2-weighted image. Br J Radiol. 2016;89(1062):20151074.PubMedPubMedCentral Park H, Lee SY, Rho MH, Chung EC, Ahn JH, Park JH, et al. Usefulness of the fast spin-echo three-point Dixon (mDixon) image of the knee joint on 3.0T MRI: comparison with conventional fast spin-echo T2-weighted image. Br J Radiol. 2016;89(1062):20151074.PubMedPubMedCentral
25.
Zurück zum Zitat Kohl CA, Chivers FS, Lorans R, Roberts CC, Kransdorf MJ. Accuracy of chemical shift MR imaging in diagnosing indeterminate bone marrow lesions in the pelvis: review of a single institution’s experience. Skeletal Radiol. 2014;43(8):1079–84.PubMed Kohl CA, Chivers FS, Lorans R, Roberts CC, Kransdorf MJ. Accuracy of chemical shift MR imaging in diagnosing indeterminate bone marrow lesions in the pelvis: review of a single institution’s experience. Skeletal Radiol. 2014;43(8):1079–84.PubMed
26.
Zurück zum Zitat Zajick DC, Morrison WB, Schweitzer ME, Parellada JA, Carrino JA. Benign and malignant processes: normal values and differentiation with chemical shift MR imaging in vertebral marrow. Radiology. 2007;237(2):590–6. Zajick DC, Morrison WB, Schweitzer ME, Parellada JA, Carrino JA. Benign and malignant processes: normal values and differentiation with chemical shift MR imaging in vertebral marrow. Radiology. 2007;237(2):590–6.
27.
Zurück zum Zitat Douis H, Davies AM, Jeys L, Sian P. Chemical shift MRI can aid in the diagnosis of indeterminate skeletal lesions of the spine. Eur Radiol. 2016;26(4):932–40.PubMed Douis H, Davies AM, Jeys L, Sian P. Chemical shift MRI can aid in the diagnosis of indeterminate skeletal lesions of the spine. Eur Radiol. 2016;26(4):932–40.PubMed
28.
Zurück zum Zitat Geith T, Schmidt G, Biffar A, Dietrich O, Dürr H, Reiser M, et al. Comparison of qualitative and quantitative evaluation of diffusion-weighted MRI and chemical-shift imaging in the differentiation of benign and malignant vertebral body fractures. Am J Roentgenol. 2012;199(5):1083–92. Geith T, Schmidt G, Biffar A, Dietrich O, Dürr H, Reiser M, et al. Comparison of qualitative and quantitative evaluation of diffusion-weighted MRI and chemical-shift imaging in the differentiation of benign and malignant vertebral body fractures. Am J Roentgenol. 2012;199(5):1083–92.
29.
Zurück zum Zitat Zampa V, Cosottini M, Michelassi MC, Ortori S, Bruschini L, Bartolozzi C. Value of opposed-phase gradient-echo technique in distinguishing between benign and malignant vertebral lesions. Eur Radiol. 2002;12(7):1811–8.PubMed Zampa V, Cosottini M, Michelassi MC, Ortori S, Bruschini L, Bartolozzi C. Value of opposed-phase gradient-echo technique in distinguishing between benign and malignant vertebral lesions. Eur Radiol. 2002;12(7):1811–8.PubMed
30.
Zurück zum Zitat Costa F, Canella C, Viera F, Vianna E, Meohas W, Marchiori E. The usefulness of chemical-shift magnetic resonance imaging for the evaluation of osteoid osteoma. Radiol Bras. 2018;51(3):156–61.PubMedPubMedCentral Costa F, Canella C, Viera F, Vianna E, Meohas W, Marchiori E. The usefulness of chemical-shift magnetic resonance imaging for the evaluation of osteoid osteoma. Radiol Bras. 2018;51(3):156–61.PubMedPubMedCentral
31.
Zurück zum Zitat Schmeel FC, Luetkens JA, Wagenhäuser PJ, Meier-Schroers M, Kuetting DL, Feißt A, et al. Proton density fat fraction (PDFF) MRI for differentiation of benign and malignant vertebral lesions. Eur Radiol. 2018;28(6):2397–405.PubMed Schmeel FC, Luetkens JA, Wagenhäuser PJ, Meier-Schroers M, Kuetting DL, Feißt A, et al. Proton density fat fraction (PDFF) MRI for differentiation of benign and malignant vertebral lesions. Eur Radiol. 2018;28(6):2397–405.PubMed
32.
Zurück zum Zitat Schmeel FC, Luetkens JA, Enkirch SJ, Feißt A, Endler CH, Schmeel LC, et al. Proton density fat fraction (PDFF) MR imaging for differentiation of acute benign and neoplastic compression fractures of the spine. Eur Radiol. 2018;28(12):5001–9.PubMed Schmeel FC, Luetkens JA, Enkirch SJ, Feißt A, Endler CH, Schmeel LC, et al. Proton density fat fraction (PDFF) MR imaging for differentiation of acute benign and neoplastic compression fractures of the spine. Eur Radiol. 2018;28(12):5001–9.PubMed
33.
Zurück zum Zitat Schmeel FC, Luetkens JA, Feißt A, Enkirch SJ, Endler CH, Wagenhäuser PJ, et al. Quantitative evaluation of T2* relaxation times for the differentiation of acute benign and malignant vertebral body fractures. Eur J Radiol. 2018;108:59–65.PubMed Schmeel FC, Luetkens JA, Feißt A, Enkirch SJ, Endler CH, Wagenhäuser PJ, et al. Quantitative evaluation of T2* relaxation times for the differentiation of acute benign and malignant vertebral body fractures. Eur J Radiol. 2018;108:59–65.PubMed
34.
Zurück zum Zitat Pezeshk P, Alian A, Chhabra A. Role of chemical shift and Dixon based techniques in musculoskeletal MR imaging. Eur J Radiol. 2017;94:93–100.PubMed Pezeshk P, Alian A, Chhabra A. Role of chemical shift and Dixon based techniques in musculoskeletal MR imaging. Eur J Radiol. 2017;94:93–100.PubMed
35.
Zurück zum Zitat Suh CH, Yun SJ, Jin W, Park SY, Ryu C-W, Lee SH. Diagnostic performance of in-phase and opposed-phase chemical-shift imaging for differentiating benign and malignant vertebral marrow lesions: a meta-analysis. Am J Roentgenol. 2018;211(4):188–97. Suh CH, Yun SJ, Jin W, Park SY, Ryu C-W, Lee SH. Diagnostic performance of in-phase and opposed-phase chemical-shift imaging for differentiating benign and malignant vertebral marrow lesions: a meta-analysis. Am J Roentgenol. 2018;211(4):188–97.
36.
Zurück zum Zitat Carroll KW, Feller JF, Tirman PFJ. Useful internal standards for distinguishing infiltrative marrow pathology from hematopoietic marrow at MRI. J Magn Reson Imaging. 1997;7(2):394–8.PubMed Carroll KW, Feller JF, Tirman PFJ. Useful internal standards for distinguishing infiltrative marrow pathology from hematopoietic marrow at MRI. J Magn Reson Imaging. 1997;7(2):394–8.PubMed
37.
Zurück zum Zitat El-Samie HAEKA, El-Ghany HSA. The value of added opposed/in phase MRI sequences in characterization of the focal vertebral bone marrow lesions in oncology patients. Egypt J Radiol Nucl Med. 2015;46(3):727–32. El-Samie HAEKA, El-Ghany HSA. The value of added opposed/in phase MRI sequences in characterization of the focal vertebral bone marrow lesions in oncology patients. Egypt J Radiol Nucl Med. 2015;46(3):727–32.
38.
Zurück zum Zitat Hwang S, Panicek DM. Magnetic resonance imaging of bone marrow in oncology. I. Skeletal Radiol. 2007;36(10):913–20.PubMed Hwang S, Panicek DM. Magnetic resonance imaging of bone marrow in oncology. I. Skeletal Radiol. 2007;36(10):913–20.PubMed
39.
Zurück zum Zitat Małkiewicz A, Dziedzic M. Bone marrow reconversion—imaging of physiological changes in bone marrow. Polish J Radiol. 2012;77(4):45–50. Małkiewicz A, Dziedzic M. Bone marrow reconversion—imaging of physiological changes in bone marrow. Polish J Radiol. 2012;77(4):45–50.
40.
Zurück zum Zitat Shiga NT, Del Grande F, Lardo O, Fayad LM. Imaging of primary bone tumors: determination of tumor extent by non-contrast sequences. Pediatr Radiol. 2013;43(8):1017–23.PubMed Shiga NT, Del Grande F, Lardo O, Fayad LM. Imaging of primary bone tumors: determination of tumor extent by non-contrast sequences. Pediatr Radiol. 2013;43(8):1017–23.PubMed
41.
Zurück zum Zitat Kenneally BE, Gutowski CJ, Reynolds AW, Morrison WB, Abraham JA. Utility of opposed-phase magnetic resonance imaging in differentiating sarcoma from benign bone lesions. J Bone Oncol. 2015;4(4):110–4.PubMedPubMedCentral Kenneally BE, Gutowski CJ, Reynolds AW, Morrison WB, Abraham JA. Utility of opposed-phase magnetic resonance imaging in differentiating sarcoma from benign bone lesions. J Bone Oncol. 2015;4(4):110–4.PubMedPubMedCentral
42.
Zurück zum Zitat Del Grande F, Farahani SJ, Carrino JA, Chhabra A. Bone marrow lesions: a systematic diagnostic approach. Indian J Radiol Imaging. 2014;24(3):279–88.PubMedPubMedCentral Del Grande F, Farahani SJ, Carrino JA, Chhabra A. Bone marrow lesions: a systematic diagnostic approach. Indian J Radiol Imaging. 2014;24(3):279–88.PubMedPubMedCentral
43.
Zurück zum Zitat Kim YP, Kannengiesser S, Paek MY, Kim S, Chung TS, Yoo YH, et al. Differentiation between focal malignant marrow-replacing lesions and benign red marrow deposition of the spine with T2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence. Korean J Radiol. 2014;15(6):781–91.PubMedPubMedCentral Kim YP, Kannengiesser S, Paek MY, Kim S, Chung TS, Yoo YH, et al. Differentiation between focal malignant marrow-replacing lesions and benign red marrow deposition of the spine with T2*-corrected fat-signal fraction map using a three-echo volume interpolated breath-hold gradient echo Dixon sequence. Korean J Radiol. 2014;15(6):781–91.PubMedPubMedCentral
44.
Zurück zum Zitat Disler D, Mccauley TR, Ratner LM, Kesack C, Cooper JA. In-phase and out-of-phase MR imaging of bone marrow: prediction of neoplasia based on the detection of coexistent fat and water. Am J Roentgenol. 1997;169:1439–47. Disler D, Mccauley TR, Ratner LM, Kesack C, Cooper JA. In-phase and out-of-phase MR imaging of bone marrow: prediction of neoplasia based on the detection of coexistent fat and water. Am J Roentgenol. 1997;169:1439–47.
45.
Zurück zum Zitat Kumar NM, Ahlawat S, Fayad LM. Chemical shift imaging with in-phase and opposed-phase sequences at 3T: what is the optimal threshold, measurement method, and diagnostic accuracy for characterizing marrow signal abnormalities? Skeletal Radiol. 2018;47(12):1661–71.PubMed Kumar NM, Ahlawat S, Fayad LM. Chemical shift imaging with in-phase and opposed-phase sequences at 3T: what is the optimal threshold, measurement method, and diagnostic accuracy for characterizing marrow signal abnormalities? Skeletal Radiol. 2018;47(12):1661–71.PubMed
46.
Zurück zum Zitat Shah L, Hanrahan C. MRI of spinal bone marrow. I Techniques and normal age-related appearances. Am J Roentgenol. 2011;197:1298–308. Shah L, Hanrahan C. MRI of spinal bone marrow. I Techniques and normal age-related appearances. Am J Roentgenol. 2011;197:1298–308.
47.
Zurück zum Zitat Fayad L, Jacobs M, Wang X, Carrino J, Bluemke D. Musculoskeletal tumors: how to use anatomic, functional, and metabolic MR techniques. Radiology. 2012;265(2):340–56.PubMedPubMedCentral Fayad L, Jacobs M, Wang X, Carrino J, Bluemke D. Musculoskeletal tumors: how to use anatomic, functional, and metabolic MR techniques. Radiology. 2012;265(2):340–56.PubMedPubMedCentral
48.
Zurück zum Zitat Shigematsu Y, Hirai T, Kawanaka K, Shiraishi S, Yoshida M, Kitajima M, et al. Distinguishing imaging features between spinal hyperplastic hematopoietic bone marrow and bone metastasis. Am J Neuroradiol. 2014;35(10):2013–20.PubMedPubMedCentral Shigematsu Y, Hirai T, Kawanaka K, Shiraishi S, Yoshida M, Kitajima M, et al. Distinguishing imaging features between spinal hyperplastic hematopoietic bone marrow and bone metastasis. Am J Neuroradiol. 2014;35(10):2013–20.PubMedPubMedCentral
49.
Zurück zum Zitat Chow LTC, Ng AWH, Wong SKC. Focal nodular and diffuse haematopoietic marrow hyperplasia in patients with underlying malignancies: a radiological mimic of malignancy in need of recognition. Clin Radiol. 2017;72(3):265.e7–265.e23. Chow LTC, Ng AWH, Wong SKC. Focal nodular and diffuse haematopoietic marrow hyperplasia in patients with underlying malignancies: a radiological mimic of malignancy in need of recognition. Clin Radiol. 2017;72(3):265.e7–265.e23.
50.
Zurück zum Zitat Yoo HJ, Hong SH, Kim DH, Choi JY, Chae HD, Jeong BM, et al. Measurement of fat content in vertebral marrow using a modified Dixon sequence to differentiate benign from malignant processes. J Magn Reson Imaging. 2017;45(5):1534–44.PubMed Yoo HJ, Hong SH, Kim DH, Choi JY, Chae HD, Jeong BM, et al. Measurement of fat content in vertebral marrow using a modified Dixon sequence to differentiate benign from malignant processes. J Magn Reson Imaging. 2017;45(5):1534–44.PubMed
51.
Zurück zum Zitat Gaudino S, Martucci M, Colantonio R, Lozupone E, Visconti E, Leone A, et al. A systematic approach to vertebral hemangioma. Skeletal Radiol. 2015;44(1):25–36.PubMed Gaudino S, Martucci M, Colantonio R, Lozupone E, Visconti E, Leone A, et al. A systematic approach to vertebral hemangioma. Skeletal Radiol. 2015;44(1):25–36.PubMed
52.
Zurück zum Zitat Usmani S, Marafi F, Rasheed R, Al Kandari F, Ahmed N. Atypical hemangioma mimicking metastasis on 18F-sodium fluoride positron emission tomography-computed tomography and magnetic resonance imaging: gallium-68-prostate-specific membrane antigen positron emission tomography improves the specificity of bone lesions. Indian J Nucl Med. 2018;33(2):171–3.PubMedPubMedCentral Usmani S, Marafi F, Rasheed R, Al Kandari F, Ahmed N. Atypical hemangioma mimicking metastasis on 18F-sodium fluoride positron emission tomography-computed tomography and magnetic resonance imaging: gallium-68-prostate-specific membrane antigen positron emission tomography improves the specificity of bone lesions. Indian J Nucl Med. 2018;33(2):171–3.PubMedPubMedCentral
53.
Zurück zum Zitat Morales K, Arevalo-Perez J, Peck K, Holodny A, Lis E, Karimi S. Differentiating atypical hemangiomas and metastatic vertebral lesions: the role of T1-weighted dynamic contrast-enhanced MRI. Am J Neuroradiol. 2018;39(5):968–73.PubMedPubMedCentral Morales K, Arevalo-Perez J, Peck K, Holodny A, Lis E, Karimi S. Differentiating atypical hemangiomas and metastatic vertebral lesions: the role of T1-weighted dynamic contrast-enhanced MRI. Am J Neuroradiol. 2018;39(5):968–73.PubMedPubMedCentral
54.
Zurück zum Zitat Shi Y, Li X, Zhang X, Liu Y, Tang L, Sun Y-S. Differential diagnosis of hemangiomas from spinal osteolytic metastases using 3.0 T MRI: comparison of T1-weighted imaging, chemical-shift imaging, diffusion-weighted and contrast-enhanced imaging. Oncotarget. 2017;8(41):71095–104.PubMedPubMedCentral Shi Y, Li X, Zhang X, Liu Y, Tang L, Sun Y-S. Differential diagnosis of hemangiomas from spinal osteolytic metastases using 3.0 T MRI: comparison of T1-weighted imaging, chemical-shift imaging, diffusion-weighted and contrast-enhanced imaging. Oncotarget. 2017;8(41):71095–104.PubMedPubMedCentral
55.
Zurück zum Zitat Kim DH, Yoo HJ, Hong SH, Choi JY, Chae HD, Chung BM. Differentiation of acute osteoporotic and malignant vertebral fractures by quantification of fat fraction with a Dixon MRI sequence. Am J Roentgenol. 2017;209(6):1331–9. Kim DH, Yoo HJ, Hong SH, Choi JY, Chae HD, Chung BM. Differentiation of acute osteoporotic and malignant vertebral fractures by quantification of fat fraction with a Dixon MRI sequence. Am J Roentgenol. 2017;209(6):1331–9.
56.
Zurück zum Zitat Cicala D, Briganti F, Casale L, Rossi C, Cagini L, Cesarano E, et al. Atraumatic vertebral compression fractures: differential diagnosis between benign osteoporotic and malignant fractures by MRI. Musculoskelet Surg. 2013;97(2):S169–79.PubMed Cicala D, Briganti F, Casale L, Rossi C, Cagini L, Cesarano E, et al. Atraumatic vertebral compression fractures: differential diagnosis between benign osteoporotic and malignant fractures by MRI. Musculoskelet Surg. 2013;97(2):S169–79.PubMed
57.
Zurück zum Zitat Mauch J, Carr C, Cloft H, Diehn F. Review of the imaging features of benign osteoporotic and malignant vertebral compression fractures. Am J Neuroradiol. 2018;39(9):1584–92.PubMedPubMedCentral Mauch J, Carr C, Cloft H, Diehn F. Review of the imaging features of benign osteoporotic and malignant vertebral compression fractures. Am J Neuroradiol. 2018;39(9):1584–92.PubMedPubMedCentral
58.
Zurück zum Zitat Eito K, Waka S, Naoko N, Makoto A, Atsuko H. Vertebral neoplastic compression fractures: assessment by dual-phase chemical shift imaging. J Magn Reson Imaging. 2004;20(6):1020–4.PubMed Eito K, Waka S, Naoko N, Makoto A, Atsuko H. Vertebral neoplastic compression fractures: assessment by dual-phase chemical shift imaging. J Magn Reson Imaging. 2004;20(6):1020–4.PubMed
59.
Zurück zum Zitat Erly WK, Oh ES, Outwater EK. The utility of in-phase/opposed-phase imaging in differentiating malignancy from acute benign compression fractures of the spine. Am J Neuroradiol. 2006;27(6):1183–8.PubMedPubMedCentral Erly WK, Oh ES, Outwater EK. The utility of in-phase/opposed-phase imaging in differentiating malignancy from acute benign compression fractures of the spine. Am J Neuroradiol. 2006;27(6):1183–8.PubMedPubMedCentral
60.
Zurück zum Zitat Ragab Y, Emad Y, Gheita T, Mansour M, Abou-Zeid A, Ferrari S, et al. Differentiation of osteoporotic and neoplastic vertebral fractures by chemical shift {in-phase and out-of phase} MR imaging. Eur J Radiol. 2009;72(1):125–33.PubMed Ragab Y, Emad Y, Gheita T, Mansour M, Abou-Zeid A, Ferrari S, et al. Differentiation of osteoporotic and neoplastic vertebral fractures by chemical shift {in-phase and out-of phase} MR imaging. Eur J Radiol. 2009;72(1):125–33.PubMed
61.
Zurück zum Zitat Del Grande F, Tatizawa-Shiga N, Farahani SJ, Chalian M, Fayad LM. Chemical shift imaging: preliminary experience as an alternative sequence for defining the extent of a bone tumor. Quant Imaging Med Surg. 2014;4(3):173–80.PubMedPubMedCentral Del Grande F, Tatizawa-Shiga N, Farahani SJ, Chalian M, Fayad LM. Chemical shift imaging: preliminary experience as an alternative sequence for defining the extent of a bone tumor. Quant Imaging Med Surg. 2014;4(3):173–80.PubMedPubMedCentral
62.
Zurück zum Zitat Saifuddin A, Sharif B, Gerrand C, Whelan J. The current status of MRI in the pre-operative assessment of intramedullary conventional appendicular osteosarcoma. Skeletal Radiol. 2018;48(4):503–16.PubMed Saifuddin A, Sharif B, Gerrand C, Whelan J. The current status of MRI in the pre-operative assessment of intramedullary conventional appendicular osteosarcoma. Skeletal Radiol. 2018;48(4):503–16.PubMed
63.
Zurück zum Zitat Bray TJP, Singh S, Latifoltojar A, Rajesparan K, Rahman F, Narayanan P, et al. Diagnostic utility of whole body Dixon MRI in multiple myeloma: a multi-reader study. PLoS One. 2017;12(7):e0180562.PubMedPubMedCentral Bray TJP, Singh S, Latifoltojar A, Rajesparan K, Rahman F, Narayanan P, et al. Diagnostic utility of whole body Dixon MRI in multiple myeloma: a multi-reader study. PLoS One. 2017;12(7):e0180562.PubMedPubMedCentral
64.
Zurück zum Zitat Dutoit JC, Verstraete KL. MRI in multiple myeloma: a pictorial review of diagnostic and post-treatment findings. Insights Imaging. 2016;7:553–69.PubMedPubMedCentral Dutoit JC, Verstraete KL. MRI in multiple myeloma: a pictorial review of diagnostic and post-treatment findings. Insights Imaging. 2016;7:553–69.PubMedPubMedCentral
65.
Zurück zum Zitat Vanel D, Casadei R, Alberghini M, Razgallah M, Busacca M, Albisinni U. MR imaging of bone metastases and choice of sequence: spin echo, in-phase gradient echo, diffusion, and contrast medium. Semin Musculoskelet Radiol. 2009;1(212):97–103. Vanel D, Casadei R, Alberghini M, Razgallah M, Busacca M, Albisinni U. MR imaging of bone metastases and choice of sequence: spin echo, in-phase gradient echo, diffusion, and contrast medium. Semin Musculoskelet Radiol. 2009;1(212):97–103.
66.
67.
Zurück zum Zitat Hahn S, Lee Y, Suh J. Detection of vertebral metastases: a comparison between the modified Dixon turbo spin echo T2 weighted MRI and conventional T1 weighted MRI: a preliminary study in a tertiary centre. Br J Radiol. 2018;91(1085):20170782.PubMedPubMedCentral Hahn S, Lee Y, Suh J. Detection of vertebral metastases: a comparison between the modified Dixon turbo spin echo T2 weighted MRI and conventional T1 weighted MRI: a preliminary study in a tertiary centre. Br J Radiol. 2018;91(1085):20170782.PubMedPubMedCentral
68.
Zurück zum Zitat Ohno S, Togami I, Sei T, Ida K, Tsunoda M, Yamaoka K, et al. MR imaging of vertebral metastases at 0.2 Tesla: clinical evaluation of T1-weighted opposed-phase gradient-echo imaging. Physiol Chem Phys Med NMR. 2003;35(2):145–56.PubMed Ohno S, Togami I, Sei T, Ida K, Tsunoda M, Yamaoka K, et al. MR imaging of vertebral metastases at 0.2 Tesla: clinical evaluation of T1-weighted opposed-phase gradient-echo imaging. Physiol Chem Phys Med NMR. 2003;35(2):145–56.PubMed
69.
Zurück zum Zitat Woolf DK, Padhani AR, Makris A. Assessing response to treatment of bone metastases from breast cancer: what should be the standard of care? Ann Oncol. 2015;26(6):1048–57.PubMed Woolf DK, Padhani AR, Makris A. Assessing response to treatment of bone metastases from breast cancer: what should be the standard of care? Ann Oncol. 2015;26(6):1048–57.PubMed
70.
Zurück zum Zitat Wu Q, Yang R, Zhou F, Hu Y. Comparison of whole-body MRI and skeletal scintigraphy for detection of bone metastatic tumors: a meta-analysis. Surg Oncol. 2013;22(4):261–6.PubMed Wu Q, Yang R, Zhou F, Hu Y. Comparison of whole-body MRI and skeletal scintigraphy for detection of bone metastatic tumors: a meta-analysis. Surg Oncol. 2013;22(4):261–6.PubMed
71.
Zurück zum Zitat Morone M, Bali MA, Tunariu N, Messiou C, Blackledge M, Grazioli L, et al. Whole-body MRI: current applications in oncology. Am J Roentgenol. 2017;209:336–49. Morone M, Bali MA, Tunariu N, Messiou C, Blackledge M, Grazioli L, et al. Whole-body MRI: current applications in oncology. Am J Roentgenol. 2017;209:336–49.
72.
Zurück zum Zitat Petralia G, Padhani AR. Whole-body magnetic resonance imaging in oncology: uses and indications. Magn Reson Imaging Clin N Am. 2018;26(4):495–507.PubMed Petralia G, Padhani AR. Whole-body magnetic resonance imaging in oncology: uses and indications. Magn Reson Imaging Clin N Am. 2018;26(4):495–507.PubMed
74.
Zurück zum Zitat Guimarães MD, Noschang J, Teixeira SR, Santos MK, Lederman HM, Tostes V, et al. Whole-body MRI in pediatric patients with cancer. Cancer Imaging. 2017;17(6):1–12. Guimarães MD, Noschang J, Teixeira SR, Santos MK, Lederman HM, Tostes V, et al. Whole-body MRI in pediatric patients with cancer. Cancer Imaging. 2017;17(6):1–12.
75.
Zurück zum Zitat Ma J, Costelloe CM, Madewell JE, Hortobagyi GN, Green MC, Cao G, et al. Fast Dixon-based multisequence and multiplanar MRI for whole-body detection of cancer metastases. J Magn Reson Imaging. 2009;29(5):1154–62.PubMed Ma J, Costelloe CM, Madewell JE, Hortobagyi GN, Green MC, Cao G, et al. Fast Dixon-based multisequence and multiplanar MRI for whole-body detection of cancer metastases. J Magn Reson Imaging. 2009;29(5):1154–62.PubMed
76.
Zurück zum Zitat Costelloe CM, Kundra V, Ma J, Chasen BA, Rohren EM, Bassett RL, et al. Fast Dixon whole-body MRI for detecting distant cancer metastasis: a preliminary clinical study. J Magn Reson Imaging. 2012;35(2):399–408.PubMed Costelloe CM, Kundra V, Ma J, Chasen BA, Rohren EM, Bassett RL, et al. Fast Dixon whole-body MRI for detecting distant cancer metastasis: a preliminary clinical study. J Magn Reson Imaging. 2012;35(2):399–408.PubMed
77.
Zurück zum Zitat Costelloe CM, Madewell JE, Kundra V, Harrell RK, Bassett RL, Ma J. Conspicuity of bone metastases on fast Dixon-based multisequence whole-body MRI: clinical utility per sequence. Magn Reson Imaging. 2013;31(5):669–75.PubMedPubMedCentral Costelloe CM, Madewell JE, Kundra V, Harrell RK, Bassett RL, Ma J. Conspicuity of bone metastases on fast Dixon-based multisequence whole-body MRI: clinical utility per sequence. Magn Reson Imaging. 2013;31(5):669–75.PubMedPubMedCentral
78.
Zurück zum Zitat Nichols RE, Dixon LB. Radiographic analysis of solitary bone lesions. Radiol Clin NA. 2011;49(6):1095–114. Nichols RE, Dixon LB. Radiographic analysis of solitary bone lesions. Radiol Clin NA. 2011;49(6):1095–114.
79.
Zurück zum Zitat Costelloe CM, Madewell J. Radiography in the initial diagnosis of primary bone tumors. Am J Neuroradiol. 2013;200:3–7. Costelloe CM, Madewell J. Radiography in the initial diagnosis of primary bone tumors. Am J Neuroradiol. 2013;200:3–7.
80.
Zurück zum Zitat Stacy GS, Mahal RS, Peabody TD. Staging of bone tumors: a review with illustrative examples. Am J Roentgenol. 2006;186(4):967–76. Stacy GS, Mahal RS, Peabody TD. Staging of bone tumors: a review with illustrative examples. Am J Roentgenol. 2006;186(4):967–76.
81.
Zurück zum Zitat Nascimento D, Suchard G, Hatem M, de Abreu A. The role of magnetic resonance imaging in the evaluation of bone tumours and tumour-like lesions. Insights Imaging. 2014;5(4):419–40.PubMedPubMedCentral Nascimento D, Suchard G, Hatem M, de Abreu A. The role of magnetic resonance imaging in the evaluation of bone tumours and tumour-like lesions. Insights Imaging. 2014;5(4):419–40.PubMedPubMedCentral
82.
Zurück zum Zitat Alyas F, James S, Davies A, Saifuddin A. The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions. Eur Radiol. 2007;17(10):2675–86.PubMed Alyas F, James S, Davies A, Saifuddin A. The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions. Eur Radiol. 2007;17(10):2675–86.PubMed
83.
Zurück zum Zitat Khoo MMY, Saifuddin A. The role of MRI in image-guided needle biopsy of focal bone and soft tissue neoplasms. Skeletal Radiol. 2013;42(7):905–15.PubMed Khoo MMY, Saifuddin A. The role of MRI in image-guided needle biopsy of focal bone and soft tissue neoplasms. Skeletal Radiol. 2013;42(7):905–15.PubMed
84.
Zurück zum Zitat Oei L, Koromani F, Rivadeneira F, Zillikens MC, Oei EHG. Quantitative imaging methods in osteoporosis. Quant Imaging Med Surg. 2016;6(6):680–98.PubMedPubMedCentral Oei L, Koromani F, Rivadeneira F, Zillikens MC, Oei EHG. Quantitative imaging methods in osteoporosis. Quant Imaging Med Surg. 2016;6(6):680–98.PubMedPubMedCentral
85.
Zurück zum Zitat He J, Fang H, Li X. Vertebral bone marrow fat content in normal adults with varying bone densities at 3T magnetic resonance imaging. Acta Radiol. 2019;60(4):509–15.PubMed He J, Fang H, Li X. Vertebral bone marrow fat content in normal adults with varying bone densities at 3T magnetic resonance imaging. Acta Radiol. 2019;60(4):509–15.PubMed
86.
Zurück zum Zitat Zhao Y, Huang M, Ding J, Zhang X, Spuhler K, Hu S, et al. Prediction of abnormal bone density and osteoporosis from lumbar spine MR using modified Dixon quant in 257 subjects with quantitative computed tomography as reference. J Magn Reson Imaging. 2019;49(2):390–9.PubMed Zhao Y, Huang M, Ding J, Zhang X, Spuhler K, Hu S, et al. Prediction of abnormal bone density and osteoporosis from lumbar spine MR using modified Dixon quant in 257 subjects with quantitative computed tomography as reference. J Magn Reson Imaging. 2019;49(2):390–9.PubMed
87.
Zurück zum Zitat Glover GH, Schneider E. Three-point Dixon technique for true water/fat decomposition with B0 inhomogeneity correction. Magn Reson Med. 1991;18(2):371–83.PubMed Glover GH, Schneider E. Three-point Dixon technique for true water/fat decomposition with B0 inhomogeneity correction. Magn Reson Med. 1991;18(2):371–83.PubMed
88.
Zurück zum Zitat Yoo YH, Kim H, Lee YH, Yoon C, Paek MY, Yoo H, et al. Comparison of multi-echo Dixon methods with volume interpolated breath-hold gradient echo magnetic resonance imaging in fat-signal fraction quantification of paravertebral muscle. Korean J Radiol. 2015;16(5):1086–95.PubMedPubMedCentral Yoo YH, Kim H, Lee YH, Yoon C, Paek MY, Yoo H, et al. Comparison of multi-echo Dixon methods with volume interpolated breath-hold gradient echo magnetic resonance imaging in fat-signal fraction quantification of paravertebral muscle. Korean J Radiol. 2015;16(5):1086–95.PubMedPubMedCentral
89.
Zurück zum Zitat Swartz PG, Roberts CC. Radiological reasoning: bone marrow changes on MRI. Am J Roentgenol. 2009;193:1–4. Swartz PG, Roberts CC. Radiological reasoning: bone marrow changes on MRI. Am J Roentgenol. 2009;193:1–4.
Metadaten
Titel
The Dixon technique for MRI of the bone marrow
verfasst von
Niels van Vucht
Rodney Santiago
Bianca Lottmann
Ian Pressney
Dorothee Harder
Adnan Sheikh
Asif Saifuddin
Publikationsdatum
15.07.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Skeletal Radiology / Ausgabe 12/2019
Print ISSN: 0364-2348
Elektronische ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-019-03271-4

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