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Archives of Dermatological Research
Erschienen in: Archives of Dermatological Research 2/2010

01.03.2010 | Mini Review

Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms

verfasst von: Joi A. Nichols, Santosh K. Katiyar

Erschienen in: Archives of Dermatological Research | Ausgabe 2/2010

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Abstract

Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. The laboratory studies conducted in animal models suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.
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Metadaten
Titel
Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms
verfasst von
Joi A. Nichols
Santosh K. Katiyar
Publikationsdatum
01.03.2010
Verlag
Springer-Verlag
Erschienen in
Archives of Dermatological Research / Ausgabe 2/2010
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-009-1001-3

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