Skip to main content
Erschienen in: Archives of Gynecology and Obstetrics 3/2017

29.12.2016 | Gynecologic Oncology

Application of sentinel lymph node dissection in gynecological cancers: results of a survey among German hospitals

verfasst von: Rüdiger Klapdor, Hermann Hertel, Philipp Soergel, Matthias Jentschke, Peter Hillemanns

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Evaluating the application of the sentinel lymph node dissection (SLND) in gynecological cancers among German hospitals.

Methods

Between March and June 2016 an online questionnaire on SLND in gynecologic cancers was sent by email to all German gynecologic cancer centers, all university hospitals and general hospitals for which an email address was available. The survey contained 61 questions regarding the SLND in vulvar, cervical, endometrial and ovarian cancer.

Results

In total, 63 clinics, including 13 (20.6%) university hospitals, 28 (44.4%) hospitals offering maximum care and 22 (34.9%) general hospitals, responded to the questionnaire. Most clinics (46/63, 73%) performed SLND in vulvar cancer with a median amount of 7.8 (range 1–43) SLND per year. 56.5% of the clinics included patients according to the German national guidelines and performed ultrastaging of negative SLN. Furthermore, 18/63 (28.5%) of the responding clinics applied SLND in cervical cancer including 7 (77.8%) centers which conducted isolated SLND without radical pelvic lymph node dissection (LND). Preoperative imaging with planar lymphoscintigraphy (LSG) was applied in 12/18 (66.7%) of the clinics. SLND in endometrial cancer was reported by 4/63 (6.4%) hospitals. Three of them (75%) regularly performed a subsequent radical pelvic LND. One clinic (1.5%) reported SLND in ovarian cancer in combination with radical LND.

Conclusion

Especially in vulvar and cervical cancer, isolated SLND appears to be partially implemented in the routine surgical treatment. However, this survey illustrates a wide heterogeneity regarding inclusion criteria and application of the SLND approach.
Literatur
2.
Zurück zum Zitat Gangi A, Essner R, Giuliano AE (2014) Long-term clinical impact of sentinel lymph node biopsy in breast cancer and cutaneous melanoma. Q J Nucl Med Mol Imaging 58(2):95–104PubMed Gangi A, Essner R, Giuliano AE (2014) Long-term clinical impact of sentinel lymph node biopsy in breast cancer and cutaneous melanoma. Q J Nucl Med Mol Imaging 58(2):95–104PubMed
3.
Zurück zum Zitat Bats AS, Mathevet P, Buenerd A et al (2013) The sentinel node technique detects unexpected drainage pathways and allows nodal ultrastaging in early cervical cancer: insights from the multicenter prospective SENTICOL study. Ann Surg Oncol 20(2):413–422. doi:10.1245/s10434-012-2597-7 CrossRefPubMed Bats AS, Mathevet P, Buenerd A et al (2013) The sentinel node technique detects unexpected drainage pathways and allows nodal ultrastaging in early cervical cancer: insights from the multicenter prospective SENTICOL study. Ann Surg Oncol 20(2):413–422. doi:10.​1245/​s10434-012-2597-7 CrossRefPubMed
6.
Zurück zum Zitat Ballester M, Dubernard G, Lécuru F et al (2011) Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO). Lancet Oncol 12(5):469–476. doi:10.1016/S1470-2045(11)70070-5 CrossRefPubMed Ballester M, Dubernard G, Lécuru F et al (2011) Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO). Lancet Oncol 12(5):469–476. doi:10.​1016/​S1470-2045(11)70070-5 CrossRefPubMed
11.
Zurück zum Zitat Schnurch HG, Ackermann S, Alt CD et al. (2016) Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015. Geburtshilfe Frauenheilkd 76(10):1035–1049. doi: 10.1055/s-0042-103728 Schnurch HG, Ackermann S, Alt CD et al. (2016) Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015. Geburtshilfe Frauenheilkd 76(10):1035–1049. doi: 10.​1055/​s-0042-103728
12.
Zurück zum Zitat Levenback C, Burke TW, Gershenson DM et al (1994) Intraoperative lymphatic mapping for vulvar cancer. Obstet Gynecol 84(2):163–167PubMed Levenback C, Burke TW, Gershenson DM et al (1994) Intraoperative lymphatic mapping for vulvar cancer. Obstet Gynecol 84(2):163–167PubMed
13.
Zurück zum Zitat te Grootenhuis NC, van der Zee A, van Doorn HC et al (2016) Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V) I. Gynecol Oncol 140(1):8–14. doi:10.1016/j.ygyno.2015.09.077 CrossRef te Grootenhuis NC, van der Zee A, van Doorn HC et al (2016) Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V) I. Gynecol Oncol 140(1):8–14. doi:10.​1016/​j.​ygyno.​2015.​09.​077 CrossRef
14.
Zurück zum Zitat Oonk MH, van Hemel BM, Hollema H et al (2010) Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol 11(7):646–652. doi:10.1016/S1470-2045(10)70104-2 CrossRefPubMed Oonk MH, van Hemel BM, Hollema H et al (2010) Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol 11(7):646–652. doi:10.​1016/​S1470-2045(10)70104-2 CrossRefPubMed
15.
16.
Zurück zum Zitat Lecuru F, Mathevet P, Querleu D et al (2011) Bilateral negative sentinel nodes accurately predict absence of lymph node metastasis in early cervical cancer: results of the SENTICOL study. J Clin Oncol 29(13):1686–1691. doi:10.1200/JCO.2010.32.0432 CrossRefPubMed Lecuru F, Mathevet P, Querleu D et al (2011) Bilateral negative sentinel nodes accurately predict absence of lymph node metastasis in early cervical cancer: results of the SENTICOL study. J Clin Oncol 29(13):1686–1691. doi:10.​1200/​JCO.​2010.​32.​0432 CrossRefPubMed
17.
Zurück zum Zitat Horn L-C, Hentschel B, Fischer U et al (2008) Detection of micrometastases in pelvic lymph nodes in patients with carcinoma of the cervix uteri using step sectioning: frequency, topographic distribution and prognostic impact. Gynecol Oncol 111(2):276–281. doi:10.1016/j.ygyno.2008.07.017 CrossRefPubMed Horn L-C, Hentschel B, Fischer U et al (2008) Detection of micrometastases in pelvic lymph nodes in patients with carcinoma of the cervix uteri using step sectioning: frequency, topographic distribution and prognostic impact. Gynecol Oncol 111(2):276–281. doi:10.​1016/​j.​ygyno.​2008.​07.​017 CrossRefPubMed
18.
Zurück zum Zitat Erkanli S, Bolat F, Seydaoglu G (2011) Detection and importance of micrometastases in histologically negative lymph nodes in endometrial carcinoma. Eur J Gynaecol Oncol 32(6):619–625PubMed Erkanli S, Bolat F, Seydaoglu G (2011) Detection and importance of micrometastases in histologically negative lymph nodes in endometrial carcinoma. Eur J Gynaecol Oncol 32(6):619–625PubMed
21.
Zurück zum Zitat Ruscito I, Gasparri ML, Braicu EI et al (2016) Sentinel node mapping in cervical and endometrial cancer: indocyanine green versus other conventional dyes-A meta-analysis. Ann Surg Oncol. doi:10.1245/s10434-016-5236-x Ruscito I, Gasparri ML, Braicu EI et al (2016) Sentinel node mapping in cervical and endometrial cancer: indocyanine green versus other conventional dyes-A meta-analysis. Ann Surg Oncol. doi:10.​1245/​s10434-016-5236-x
23.
26.
Zurück zum Zitat Buda A, Crivellaro C, Elisei F et al (2016) Impact of indocyanine green for sentinel lymph node mapping in early stage endometrial and cervical cancer: comparison with conventional radiotracer (99 m)Tc and/or Blue Dye. Ann Surg Oncol 23(7):2183–2191. doi:10.1245/s10434-015-5022-1 CrossRefPubMed Buda A, Crivellaro C, Elisei F et al (2016) Impact of indocyanine green for sentinel lymph node mapping in early stage endometrial and cervical cancer: comparison with conventional radiotracer (99 m)Tc and/or Blue Dye. Ann Surg Oncol 23(7):2183–2191. doi:10.​1245/​s10434-015-5022-1 CrossRefPubMed
27.
Zurück zum Zitat Jewell EL, Huang JJ, Abu-Rustum NR et al (2014) Detection of sentinel lymph nodes in minimally invasive surgery using indocyanine green and near-infrared fluorescence imaging for uterine and cervical malignancies. Gynecol Oncol 133(2):274–277. doi:10.1016/j.ygyno.2014.02.028 CrossRefPubMed Jewell EL, Huang JJ, Abu-Rustum NR et al (2014) Detection of sentinel lymph nodes in minimally invasive surgery using indocyanine green and near-infrared fluorescence imaging for uterine and cervical malignancies. Gynecol Oncol 133(2):274–277. doi:10.​1016/​j.​ygyno.​2014.​02.​028 CrossRefPubMed
30.
Zurück zum Zitat Burke TW, Levenback C, Tornos C et al (1996) Intraabdominal lymphatic mapping to direct selective pelvic and paraaortic lymphadenectomy in women with high-risk endometrial cancer: results of a pilot study. Gynecol Oncol 62(2):169–173. doi:10.1006/gyno.1996.0211 CrossRefPubMed Burke TW, Levenback C, Tornos C et al (1996) Intraabdominal lymphatic mapping to direct selective pelvic and paraaortic lymphadenectomy in women with high-risk endometrial cancer: results of a pilot study. Gynecol Oncol 62(2):169–173. doi:10.​1006/​gyno.​1996.​0211 CrossRefPubMed
31.
Zurück zum Zitat ASTEC study group, Kitchener H, Swart AM et al (2009) Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): A randomised study. Lancet 373(9658):125–136. doi:10.1016/S0140-6736(08)61766-3 CrossRef ASTEC study group, Kitchener H, Swart AM et al (2009) Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): A randomised study. Lancet 373(9658):125–136. doi:10.​1016/​S0140-6736(08)61766-3 CrossRef
32.
Zurück zum Zitat Benedetti Panici P, Basile S, Maneschi F et al (2008) Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst 100(23):1707–1716. doi:10.1093/jnci/djn397 CrossRefPubMed Benedetti Panici P, Basile S, Maneschi F et al (2008) Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst 100(23):1707–1716. doi:10.​1093/​jnci/​djn397 CrossRefPubMed
34.
Zurück zum Zitat Panici PB, Maggioni A, Hacker N et al (2005) Systematic aortic and pelvic lymphadenectomy versus resection of bulky nodes only in optimally debulked advanced ovarian cancer: a randomized clinical trial. J Natl Cancer Inst 97(8):560–566. doi:10.1093/jnci/dji102 CrossRefPubMed Panici PB, Maggioni A, Hacker N et al (2005) Systematic aortic and pelvic lymphadenectomy versus resection of bulky nodes only in optimally debulked advanced ovarian cancer: a randomized clinical trial. J Natl Cancer Inst 97(8):560–566. doi:10.​1093/​jnci/​dji102 CrossRefPubMed
37.
Zurück zum Zitat Mammary Fold Academic and Research Collaborative (2016) Variation in the management of ductal carcinoma in situ in the UK: results of the mammary fold national practice survey. Eur J Surg Oncol 42(8):1153–1161. doi:10.1016/j.ejso.2016.05.024 CrossRef Mammary Fold Academic and Research Collaborative (2016) Variation in the management of ductal carcinoma in situ in the UK: results of the mammary fold national practice survey. Eur J Surg Oncol 42(8):1153–1161. doi:10.​1016/​j.​ejso.​2016.​05.​024 CrossRef
38.
Zurück zum Zitat Vugts G, Maaskant-Braat AJG, de Roos WK et al (2016) Management of the axilla after neoadjuvant chemotherapy for clinically node positive breast cancer: a nationwide survey study in The Netherlands. Eur J Surg Oncol 42(7):956–964. doi:10.1016/j.ejso.2016.03.023 CrossRefPubMed Vugts G, Maaskant-Braat AJG, de Roos WK et al (2016) Management of the axilla after neoadjuvant chemotherapy for clinically node positive breast cancer: a nationwide survey study in The Netherlands. Eur J Surg Oncol 42(7):956–964. doi:10.​1016/​j.​ejso.​2016.​03.​023 CrossRefPubMed
Metadaten
Titel
Application of sentinel lymph node dissection in gynecological cancers: results of a survey among German hospitals
verfasst von
Rüdiger Klapdor
Hermann Hertel
Philipp Soergel
Matthias Jentschke
Peter Hillemanns
Publikationsdatum
29.12.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 3/2017
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-016-4279-3

Weitere Artikel der Ausgabe 3/2017

Archives of Gynecology and Obstetrics 3/2017 Zur Ausgabe

Alter der Mutter beeinflusst Risiko für kongenitale Anomalie

28.05.2024 Kinder- und Jugendgynäkologie Nachrichten

Welchen Einfluss das Alter ihrer Mutter auf das Risiko hat, dass Kinder mit nicht chromosomal bedingter Malformation zur Welt kommen, hat eine ungarische Studie untersucht. Sie zeigt: Nicht nur fortgeschrittenes Alter ist riskant.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mammakarzinom: Brustdichte beeinflusst rezidivfreies Überleben

26.05.2024 Mammakarzinom Nachrichten

Frauen, die zum Zeitpunkt der Brustkrebsdiagnose eine hohe mammografische Brustdichte aufweisen, haben ein erhöhtes Risiko für ein baldiges Rezidiv, legen neue Daten nahe.

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.