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Archives of Gynecology and Obstetrics

Erschienen in:

05.09.2021 | Review

Risk factors associated with HPV persistence after conization in high-grade squamous intraepithelial lesion

verfasst von: Lejing Zang, Yan Hu

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 6/2021

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Abstract

Objective

Persistence of HPV infection in patients with high-grade squamous intraepithelial lesion (HSIL) undergoing cervical excision is considered strongly associated with the recurrence and progression of cervical dysplasia. This study aims to review potential risk factors for persistence of HPV infection in patients with HSIL, thus optimizing the postoperative monitoring program and clinical treatment.

Methods

Through literature review, published data about estimated prognostic risk factors for persistence of HPV infection in patients with HSIL after conization within two decades were searched and analyzed, and their references were manually reviewed as well.

Results

Women with persistence of HPV infection after cervical excision were at an extremely high risk of disease recurrence and progression to cervical cancer. Some clinicopathological and even physiological elements involving viral, organic human body and treatment factors, such as human papillomavirus (HPV) 16, high viral load, age older than 50 years and positive surgical margin were of prognostic significance in persistent HPV infection in patients with HSIL, yet some of which still remained controversial.

Conclusions

Monitoring prognostic factors in women with persistence of HPV infection who have underwent cervical excision for HSIL are of great significance, especially the follow-up within 2 years postoperatively, which significantly improves the clinical outcome.

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Titel: Risk factors associated with HPV persistence after conization in high-grade squamous intraepithelial lesion
verfasst von: Lejing Zang
Yan Hu
Publikationsdatum: 05.09.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 6/2021
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-021-06217-1

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Risk factors associated with HPV persistence after conization in high-grade squamous intraepithelial lesion

Abstract

Objective

Methods

Results

Conclusions

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Abstract

Objective

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Conclusions

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