Erschienen in:
01.08.2009 | Original Paper
Medical history and risk of lymphoma: results of a European case–control study (EPILYMPH)
verfasst von:
Nikolaus Becker, Joan Fortuny, Tomas Alvaro, Alexandra Nieters, Marc Maynadié, Lenka Foretova, Anthony Staines, Paul Brennan, Paolo Boffetta, Pier Luigi Cocco, Silvia de Sanjose
Erschienen in:
Journal of Cancer Research and Clinical Oncology
|
Ausgabe 8/2009
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Abstract
Introduction
Lymphomas are a heterogeneous group of immune-cell malignancies. Immunology-related conditions are among the few factors for which consistent evidence exists relating them to lymphoma risk.
Materials and methods
We used the data from the European case–control study Epilymph on 2,362 lymphoma cases and 2,458 controls to investigate associations between a medical history of infectious and non-infectious diseases with overall and subentity-specific lymphoma risk.
Results
As key results, we observed an increased odds ratio (OR) for self-reported infections with hepatitis B virus (HBV, OR = 1.91, 95% CL = 1.24–2.94) and a null result for rheumatoid arthritis. Additionally, we found an increased OR for infectious mononucleosis (OR = 1.68, 95% CL = 1.14–2.48), an inverse association to frequency of sickness in childhood (OR = 0.68, 95% CL = 0.55–0.84), and—as casual finding—an increased OR with acetaminophen intake (OR = 2.29, 95% CL = 1.49–3.51).
Conclusion
Our results are consistent with the current knowledge about the association with mononucleosis as indicator of Epstein–Barr-virus infection, suggest serological study of the association to HBV infection and do not support the view of a positive association between rheumatoid arthritis and lymphoma risk.