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13.03.2018 | Original Article

Outcome of renal transplantation in small infants: a match-controlled analysis

verfasst von: Marcus Weitz, Guido F. Laube, Maria Schmidt, Kai Krupka, Luisa Murer, Dominik Müller, Bernd Hoppe, Anja Büscher, Jens König, Martin Pohl, Therese Jungraithmayr, Florian Thiel, Heiko Billing, Ryszard Grenda, Jacek Rubik, Michael M. Kaabak, Fatos Yalcinkaya, Rezan Topaloglu, Nicholas Webb, Luca Dello Strologo, Lars Pape, Silvio Nadalin, Burkhard Tönshoff

Erschienen in: Pediatric Nephrology | Ausgabe 6/2018

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Abstract

Background

Infants with a body weight of less than 10 kg are often not considered to be suitable candidates for renal transplantation (RTx). The objective of this study was to evaluate this arbitrary weight threshold for pediatric RTx.

Methods

We conducted a multicenter, retrospective, match-controlled cohort study on infants weighing less than 10 kg at time of engrafting (low-weight group [LWG], n = 38) compared to a matched control group (n = 76) with a body weight of 10–15 kg, using data from the first 2 years post-transplant derived from the CERTAIN Registry.

Results

Patient survival was 97 and 100% in the LWG and control groups, respectively (P = 0.33), and death-censored graft survival was 100 and 95% in the LWG and control groups, respectively (P = 0.30). Estimated glomerular filtration rate at 2 years post-transplant was excellent and comparable between the groups (LWG 77.6 ± 34.9 mL/min/1.73 m²; control 74.8 ± 29.1 mL/min/1.73 m²; P = 0.68). The overall incidences of surgery-related complications (LWG 11%, control 23%; P = 0.12) and medical outcome measures (LWG 23%, control 36%, P = 0.17) were not significantly different between the groups. The medical outcome measures included transplant-related viral diseases (LWG 10%, control 21%; P = 0.20), acute rejection episodes (LWG 14%, control 29%; P = 0.092), malignancies (LWG 3%, control 0%; P = 0.33) and arterial hypertension (LWG 73%, control 67%; P = 0.57).

Conclusions

These data suggest that RTx in low-weight children is a feasible option, at least in selected centers with appropriate surgical and medical expertise.

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Titel: Outcome of renal transplantation in small infants: a match-controlled analysis
verfasst von: Marcus Weitz
Guido F. Laube
Maria Schmidt
Kai Krupka
Luisa Murer
Dominik Müller
Bernd Hoppe
Anja Büscher
Jens König
Martin Pohl
Therese Jungraithmayr
Florian Thiel
Heiko Billing
Ryszard Grenda
Jacek Rubik
Michael M. Kaabak
Fatos Yalcinkaya
Rezan Topaloglu
Nicholas Webb
Luca Dello Strologo
Lars Pape
Silvio Nadalin
Burkhard Tönshoff
Publikationsdatum: 13.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 6/2018
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-018-3895-5

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Outcome of renal transplantation in small infants: a match-controlled analysis