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Erschienen in: Metabolic Brain Disease 1/2010

01.03.2010 | Original Paper

100 cc 3% sodium chloride bolus: a novel treatment for hyponatremic encephalopathy

verfasst von: Michael L. Moritz, Juan Carlos Ayus

Erschienen in: Metabolic Brain Disease | Ausgabe 1/2010

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Abstract

Hyponatremic encephalopathy is a potentially lethal condition with numerous reports of death or permanent neurological injury. The optimal treatment for hyponatremic encephalopathy remains controversial. We have introduced a unified approach to the treatment of hyponatremic encephalopathy which uses 3% NaCl (513 mEq/L) bolus therapy. Any patient with suspected hyponatremic encephalopathy should receive a 2 cc/kg bolus of 3% NaCl with a maximum of 100 cc, which could be repeated 1–2 times if symptoms persist. The approach results in a controlled and immediate rise in serum sodium with little risk of inadvertent overcorrection.
Literatur
Zurück zum Zitat Arieff AI, Ayus JC et al (1992) Hyponatraemia and death or permanent brain damage in healthy children. BMJ 304(6836):1218–1222CrossRefPubMed Arieff AI, Ayus JC et al (1992) Hyponatraemia and death or permanent brain damage in healthy children. BMJ 304(6836):1218–1222CrossRefPubMed
Zurück zum Zitat Arieff AI, Kozniewska E et al (1995) Age, gender, and vasopressin affect survival and brain adaptation in rats with metabolic encephalopathy. Am J Physiol 268(5 Pt 2):R1143–R1152PubMed Arieff AI, Kozniewska E et al (1995) Age, gender, and vasopressin affect survival and brain adaptation in rats with metabolic encephalopathy. Am J Physiol 268(5 Pt 2):R1143–R1152PubMed
Zurück zum Zitat Ayus JC, Achinger SG et al (2008) Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia. Am J Physiol Renal Physiol 295(3):F619–F624CrossRefPubMed Ayus JC, Achinger SG et al (2008) Brain cell volume regulation in hyponatremia: role of sex, age, vasopressin, and hypoxia. Am J Physiol Renal Physiol 295(3):F619–F624CrossRefPubMed
Zurück zum Zitat Ayus JC, Arieff A et al (2005) Hyponatremia in marathon runners. N Engl J Med 353(4):427–428CrossRefPubMed Ayus JC, Arieff A et al (2005) Hyponatremia in marathon runners. N Engl J Med 353(4):427–428CrossRefPubMed
Zurück zum Zitat Ayus JC, Arieff AI (1993) Pathogenesis and prevention of hyponatremic encephalopathy. Endocrinol Metab Clin North Am 22(2):425–446PubMed Ayus JC, Arieff AI (1993) Pathogenesis and prevention of hyponatremic encephalopathy. Endocrinol Metab Clin North Am 22(2):425–446PubMed
Zurück zum Zitat Ayus JC, Arieff AI (1995) Pulmonary complications of hyponatremic encephalopathy. Noncardiogenic pulmonary edema and hypercapnic respiratory failure. Chest 107(2):517–521CrossRefPubMed Ayus JC, Arieff AI (1995) Pulmonary complications of hyponatremic encephalopathy. Noncardiogenic pulmonary edema and hypercapnic respiratory failure. Chest 107(2):517–521CrossRefPubMed
Zurück zum Zitat Ayus JC, Arieff AI (1996) Brain damage and postoperative hyponatremia: the role of gender. Neurology 46(2):323–328PubMed Ayus JC, Arieff AI (1996) Brain damage and postoperative hyponatremia: the role of gender. Neurology 46(2):323–328PubMed
Zurück zum Zitat Ayus JC, Arieff AI (1999) Chronic hyponatremic encephalopathy in postmenopausal women: association of therapies with morbidity and mortality. JAMA 281(24):2299–2304CrossRefPubMed Ayus JC, Arieff AI (1999) Chronic hyponatremic encephalopathy in postmenopausal women: association of therapies with morbidity and mortality. JAMA 281(24):2299–2304CrossRefPubMed
Zurück zum Zitat Ayus JC, Arieff AI (2002a) Therapy of dDAVP-associated hyponatremia can lead to permanent brain damage. J Am Soc Nephrol 13:671A Ayus JC, Arieff AI (2002a) Therapy of dDAVP-associated hyponatremia can lead to permanent brain damage. J Am Soc Nephrol 13:671A
Zurück zum Zitat Ayus, J. C. and A. I. Arieff (2002b) Therapy of dDAVP-associated hyponatremia can lead to permanent brain damage. J Am Soc Nephrol 13: PUB002. Ayus, J. C. and A. I. Arieff (2002b) Therapy of dDAVP-associated hyponatremia can lead to permanent brain damage. J Am Soc Nephrol 13: PUB002.
Zurück zum Zitat Ayus JC, Armstrong D et al (2006) Hyponatremia with hypoxia: effects on brain adaptation, perfusion, and histology in rodents. Kidney Int 69(8):1319–1325PubMed Ayus JC, Armstrong D et al (2006) Hyponatremia with hypoxia: effects on brain adaptation, perfusion, and histology in rodents. Kidney Int 69(8):1319–1325PubMed
Zurück zum Zitat Ayus JC, Krothapalli RK et al (1987) Treatment of symptomatic hyponatremia and its relation to brain damage. A prospective study. N Engl J Med 317(19):1190–1195PubMed Ayus JC, Krothapalli RK et al (1987) Treatment of symptomatic hyponatremia and its relation to brain damage. A prospective study. N Engl J Med 317(19):1190–1195PubMed
Zurück zum Zitat Ayus JC, Krothapalli RK et al (1985) Rapid correction of severe hyponatremia in the rat: histopathological changes in the brain. Am J Physiol 248(5 Pt 2):F711–F719PubMed Ayus JC, Krothapalli RK et al (1985) Rapid correction of severe hyponatremia in the rat: histopathological changes in the brain. Am J Physiol 248(5 Pt 2):F711–F719PubMed
Zurück zum Zitat Ayus JC, Krothapalli RK et al (1989) Symptomatic hyponatremia in rats: effect of treatment on mortality and brain lesions. Am J Physiol 257(1 Pt 2):F18–F22PubMed Ayus JC, Krothapalli RK et al (1989) Symptomatic hyponatremia in rats: effect of treatment on mortality and brain lesions. Am J Physiol 257(1 Pt 2):F18–F22PubMed
Zurück zum Zitat Ayus JC, Varon J et al (2000) Hyponatremia, cerebral edema, and noncardiogenic pulmonary edema in marathon runners. Ann Intern Med 132(9):711–714PubMed Ayus JC, Varon J et al (2000) Hyponatremia, cerebral edema, and noncardiogenic pulmonary edema in marathon runners. Ann Intern Med 132(9):711–714PubMed
Zurück zum Zitat Ayus JC, Wheeler JM et al (1992) Postoperative hyponatremic encephalopathy in menstruant women. Ann Intern Med 117(11):891–897PubMed Ayus JC, Wheeler JM et al (1992) Postoperative hyponatremic encephalopathy in menstruant women. Ann Intern Med 117(11):891–897PubMed
Zurück zum Zitat Campbell GA, Rosner MH (2008) The agony of ecstasy: MDMA (3,4-methylenedioxymethamphetamine) and the kidney. Clin J Am Soc Nephrol 3(6):1852–1860CrossRefPubMed Campbell GA, Rosner MH (2008) The agony of ecstasy: MDMA (3,4-methylenedioxymethamphetamine) and the kidney. Clin J Am Soc Nephrol 3(6):1852–1860CrossRefPubMed
Zurück zum Zitat Decaux G, Soupart A (2003) Treatment of symptomatic hyponatremia. Am J Med Sci 326(1):25–30CrossRefPubMed Decaux G, Soupart A (2003) Treatment of symptomatic hyponatremia. Am J Med Sci 326(1):25–30CrossRefPubMed
Zurück zum Zitat Decaux G, Soupart A et al (2008) Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet 371(9624):1624–1632CrossRefPubMed Decaux G, Soupart A et al (2008) Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet 371(9624):1624–1632CrossRefPubMed
Zurück zum Zitat Dellabarca C, Servilla KS et al (2005) Osmotic myelinolysis following chronic hyponatremia corrected at an overall rate consistent with current recommendations. Int Urol Nephrol 37(1):171–173CrossRefPubMed Dellabarca C, Servilla KS et al (2005) Osmotic myelinolysis following chronic hyponatremia corrected at an overall rate consistent with current recommendations. Int Urol Nephrol 37(1):171–173CrossRefPubMed
Zurück zum Zitat Doczi T, Laszlo FA et al (1984) Involvement of vasopressin in brain edema formation: further evidence obtained from the Brattleboro diabetes insipidus rat with experimental subarachnoid hemorrhage. Neurosurgery 14(4):436–441PubMedCrossRef Doczi T, Laszlo FA et al (1984) Involvement of vasopressin in brain edema formation: further evidence obtained from the Brattleboro diabetes insipidus rat with experimental subarachnoid hemorrhage. Neurosurgery 14(4):436–441PubMedCrossRef
Zurück zum Zitat Gankam Kengne F, Soupart A et al (2009) Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int 76(6):614–621CrossRefPubMed Gankam Kengne F, Soupart A et al (2009) Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int 76(6):614–621CrossRefPubMed
Zurück zum Zitat Georgy V, Mullhi D et al (2007) Central pontine myelinolysis following ‘optimal’ rate of correction of hyponatraemia with a good clinical outcome. Ann Clin Biochem 44(Pt 5):488–490CrossRefPubMed Georgy V, Mullhi D et al (2007) Central pontine myelinolysis following ‘optimal’ rate of correction of hyponatraemia with a good clinical outcome. Ann Clin Biochem 44(Pt 5):488–490CrossRefPubMed
Zurück zum Zitat Germiniani FM, Roriz M et al (2002) [Central pontine and extra-pontine myelinolysis in an alcoholic patient without hydro-electrolyte disturbances: case report]. Arq Neuropsiquiatr 60(4):1030–1033PubMed Germiniani FM, Roriz M et al (2002) [Central pontine and extra-pontine myelinolysis in an alcoholic patient without hydro-electrolyte disturbances: case report]. Arq Neuropsiquiatr 60(4):1030–1033PubMed
Zurück zum Zitat Goldszmidt MA, Iliescu EA (2000) DDAVP to prevent rapid correction in hyponatremia. Clin Nephrol 53(3):226–229PubMed Goldszmidt MA, Iliescu EA (2000) DDAVP to prevent rapid correction in hyponatremia. Clin Nephrol 53(3):226–229PubMed
Zurück zum Zitat Hagiwara K, Okada Y et al (2008) Extensive central and extrapontine myelinolysis in a case of chronic alcoholism without hyponatremia: a case report with analysis of serial MR findings. Intern Med 47(5):431–435CrossRefPubMed Hagiwara K, Okada Y et al (2008) Extensive central and extrapontine myelinolysis in a case of chronic alcoholism without hyponatremia: a case report with analysis of serial MR findings. Intern Med 47(5):431–435CrossRefPubMed
Zurück zum Zitat Hew-Butler T, Ayus JC et al (2008) Statement of the Second International Exercise-Associated Hyponatremia Consensus Development Conference, New Zealand, 2007. Clin J Sport Med 18(2):111–121CrossRefPubMed Hew-Butler T, Ayus JC et al (2008) Statement of the Second International Exercise-Associated Hyponatremia Consensus Development Conference, New Zealand, 2007. Clin J Sport Med 18(2):111–121CrossRefPubMed
Zurück zum Zitat Hoorn EJ, Lindemans J et al (2006) Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management. Nephrol Dial Transplant 21(1):70–76CrossRefPubMed Hoorn EJ, Lindemans J et al (2006) Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management. Nephrol Dial Transplant 21(1):70–76CrossRefPubMed
Zurück zum Zitat Huda MS, Boyd A et al (2006) Investigation and management of severe hyponatraemia in a hospital setting. Postgrad Med J 82(965):216–219CrossRefPubMed Huda MS, Boyd A et al (2006) Investigation and management of severe hyponatraemia in a hospital setting. Postgrad Med J 82(965):216–219CrossRefPubMed
Zurück zum Zitat Kalantar-Zadeh K, Nguyen MK et al (2006) Fatal hyponatremia in a young woman after ecstasy ingestion. Nat Clin Pract Nephrol 2(5):283–288, quiz 289CrossRefPubMed Kalantar-Zadeh K, Nguyen MK et al (2006) Fatal hyponatremia in a young woman after ecstasy ingestion. Nat Clin Pract Nephrol 2(5):283–288, quiz 289CrossRefPubMed
Zurück zum Zitat Kimelberg HK (2004) Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytes. Neurochem Int 45(4):511–519CrossRefPubMed Kimelberg HK (2004) Increased release of excitatory amino acids by the actions of ATP and peroxynitrite on volume-regulated anion channels (VRACs) in astrocytes. Neurochem Int 45(4):511–519CrossRefPubMed
Zurück zum Zitat Kozniewska E, Gadamski R et al (2008) Morphological changes in the brain during experimental hyponatraemia. Do vasopressin and gender matter? Folia Neuropathol 46(4):271–277PubMed Kozniewska E, Gadamski R et al (2008) Morphological changes in the brain during experimental hyponatraemia. Do vasopressin and gender matter? Folia Neuropathol 46(4):271–277PubMed
Zurück zum Zitat Lauriat SM, Berl T (1997) The hyponatremic patient: practical focus on therapy. J Am Soc Nephrol 8(10):1599–1607PubMed Lauriat SM, Berl T (1997) The hyponatremic patient: practical focus on therapy. J Am Soc Nephrol 8(10):1599–1607PubMed
Zurück zum Zitat McClellan MD, Dauber IM et al (1989) Elevated intracranial pressure increases pulmonary vascular permeability to protein. J Appl Physiol 67(3):1185–1191PubMed McClellan MD, Dauber IM et al (1989) Elevated intracranial pressure increases pulmonary vascular permeability to protein. J Appl Physiol 67(3):1185–1191PubMed
Zurück zum Zitat Montanana PA, iAlapont Modesto et al (2008) The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study. Pediatr Crit Care Med 9(6):589–597CrossRefPubMed Montanana PA, iAlapont Modesto et al (2008) The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study. Pediatr Crit Care Med 9(6):589–597CrossRefPubMed
Zurück zum Zitat Moritz ML, Ayus JC (2003) Prevention of hospital-acquired hyponatremia: a case for using isotonic saline. Pediatrics 111(2):227–230CrossRefPubMed Moritz ML, Ayus JC (2003) Prevention of hospital-acquired hyponatremia: a case for using isotonic saline. Pediatrics 111(2):227–230CrossRefPubMed
Zurück zum Zitat Moritz ML, Ayus JC (2005) Preventing neurological complications from dysnatremias in children. Pediatr Nephrol 20(12):1687–1700CrossRefPubMed Moritz ML, Ayus JC (2005) Preventing neurological complications from dysnatremias in children. Pediatr Nephrol 20(12):1687–1700CrossRefPubMed
Zurück zum Zitat Moritz ML, Ayus JC (2008) Exercise-associated hyponatremia: why are athletes still dying? Clin J Sport Med 18(5):379–381CrossRefPubMed Moritz ML, Ayus JC (2008) Exercise-associated hyponatremia: why are athletes still dying? Clin J Sport Med 18(5):379–381CrossRefPubMed
Zurück zum Zitat Moritz, M. L. and J. C. Ayus (2009) New aspects in the pathogenesis, prevention, and treatment of hyponatremic encephalopathy in children. Pediatr Nephrol [Epub ahead of print]. Moritz, M. L. and J. C. Ayus (2009) New aspects in the pathogenesis, prevention, and treatment of hyponatremic encephalopathy in children. Pediatr Nephrol [Epub ahead of print].
Zurück zum Zitat Moritz ML, Carlos Ayus J (2007) Hospital-acquired hyponatremia-why are hypotonic parenteral fluids still being used? Nat Clin Pract Nephrol 3(7):374–382CrossRefPubMed Moritz ML, Carlos Ayus J (2007) Hospital-acquired hyponatremia-why are hypotonic parenteral fluids still being used? Nat Clin Pract Nephrol 3(7):374–382CrossRefPubMed
Zurück zum Zitat Nagaishi A, Yukitake M et al (2007) [A case of alcoholic with vitamin B12 deficiency presenting central pontine and extrapontine myelinolysis on MRI]. Rinsho Shinkeigaku 47(4):173–176PubMed Nagaishi A, Yukitake M et al (2007) [A case of alcoholic with vitamin B12 deficiency presenting central pontine and extrapontine myelinolysis on MRI]. Rinsho Shinkeigaku 47(4):173–176PubMed
Zurück zum Zitat Neville, K. A., D. J. Sandeman, et al. (2009) Prevention of Hyponatremia during Maintenance Intravenous Fluid Administration: A Prospective Randomized Study of Fluid Type versus Fluid Rate. J Pediatr 156(2):313–319. [Epub 2009 Oct 9]. Neville, K. A., D. J. Sandeman, et al. (2009) Prevention of Hyponatremia during Maintenance Intravenous Fluid Administration: A Prospective Randomized Study of Fluid Type versus Fluid Rate. J Pediatr 156(2):313–319. [Epub 2009 Oct 9].
Zurück zum Zitat Nzerue C, Baffoe-Bonnie H et al (2002) Predicters of mortality with severe hyponatremia. J Am Soc Nephrol 13:A0728 Nzerue C, Baffoe-Bonnie H et al (2002) Predicters of mortality with severe hyponatremia. J Am Soc Nephrol 13:A0728
Zurück zum Zitat Orakzai RH, Orakzai SH et al (2008) Treating hyponatremia: how slow is safe? Central pontine myelinolysis despite appropriate correction of hyponatremia. Eur J Intern Med 19(6):e29–e31CrossRefPubMed Orakzai RH, Orakzai SH et al (2008) Treating hyponatremia: how slow is safe? Central pontine myelinolysis despite appropriate correction of hyponatremia. Eur J Intern Med 19(6):e29–e31CrossRefPubMed
Zurück zum Zitat Palmer BF, Sterns RH (2009) Fluid, Electrolytes and Acid-Base Disturbances. Nephrol Self Assess Program 8(2):136–142 Palmer BF, Sterns RH (2009) Fluid, Electrolytes and Acid-Base Disturbances. Nephrol Self Assess Program 8(2):136–142
Zurück zum Zitat Perianayagam A, Sterns RH et al (2008) DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia. Clin J Am Soc Nephrol 3(2):331–336CrossRefPubMed Perianayagam A, Sterns RH et al (2008) DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia. Clin J Am Soc Nephrol 3(2):331–336CrossRefPubMed
Zurück zum Zitat Pradhan S, Jha R et al (1995) Central pontine myelinolysis following ‘slow’ correction of hyponatremia. Clin Neurol Neurosurg 97(4):340–343CrossRefPubMed Pradhan S, Jha R et al (1995) Central pontine myelinolysis following ‘slow’ correction of hyponatremia. Clin Neurol Neurosurg 97(4):340–343CrossRefPubMed
Zurück zum Zitat Savasta S, Sepe V et al (2006) Severe hyponatremia followed by extrapontine myelinolysis. Kidney Int 69(3):423CrossRefPubMed Savasta S, Sepe V et al (2006) Severe hyponatremia followed by extrapontine myelinolysis. Kidney Int 69(3):423CrossRefPubMed
Zurück zum Zitat Schoonman GG, Sandor PS et al (2008) Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging study. J Cereb Blood Flow Metab 28(1):198–206CrossRefPubMed Schoonman GG, Sandor PS et al (2008) Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema: a 3 T magnetic resonance imaging study. J Cereb Blood Flow Metab 28(1):198–206CrossRefPubMed
Zurück zum Zitat Schuster M, Diekmann S et al (2009) Central pontine myelinolysis despite slow sodium rise in a case of severe community-acquired hyponatraemia. Anaesth Intensive Care 37(1):117–120PubMed Schuster M, Diekmann S et al (2009) Central pontine myelinolysis despite slow sodium rise in a case of severe community-acquired hyponatraemia. Anaesth Intensive Care 37(1):117–120PubMed
Zurück zum Zitat Smith WS, Matthay MA (1997) Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Chest 111(5):1326–1333CrossRefPubMed Smith WS, Matthay MA (1997) Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Chest 111(5):1326–1333CrossRefPubMed
Zurück zum Zitat Soupart A, Penninckx R et al (1992) Treatment of chronic hyponatremia in rats by intravenous saline: comparison of rate versus magnitude of correction. Kidney Int 41(6):1662–1667CrossRefPubMed Soupart A, Penninckx R et al (1992) Treatment of chronic hyponatremia in rats by intravenous saline: comparison of rate versus magnitude of correction. Kidney Int 41(6):1662–1667CrossRefPubMed
Zurück zum Zitat Sterns RH, Nigwekar SU et al (2009) The treatment of hyponatremia. Semin Nephrol 29(3):282–299CrossRefPubMed Sterns RH, Nigwekar SU et al (2009) The treatment of hyponatremia. Semin Nephrol 29(3):282–299CrossRefPubMed
Zurück zum Zitat Sundgren PC, Reinstrup P et al (2002) Value of conventional, and diffusion-and perfusion weighted MRI in the management of patients with unclear cerebral pathology, admitted to the intensive care unit. Neuroradiology 44(8):674–680CrossRefPubMed Sundgren PC, Reinstrup P et al (2002) Value of conventional, and diffusion-and perfusion weighted MRI in the management of patients with unclear cerebral pathology, admitted to the intensive care unit. Neuroradiology 44(8):674–680CrossRefPubMed
Zurück zum Zitat Tan H, Onbas O (2004) Central pontine myelinolysis central pontine myelinolysis manifesting with massive myoclonus. Pediatr Neurol 31(1):64–66CrossRefPubMed Tan H, Onbas O (2004) Central pontine myelinolysis central pontine myelinolysis manifesting with massive myoclonus. Pediatr Neurol 31(1):64–66CrossRefPubMed
Zurück zum Zitat Vajda Z, Pedersen M et al (2001) Effects of centrally administered arginine vasopressin and atrial natriuretic peptide on the development of brain edema in hyponatremic rats. Neurosurgery 49(3):697–704, discussion 704–5CrossRefPubMed Vajda Z, Pedersen M et al (2001) Effects of centrally administered arginine vasopressin and atrial natriuretic peptide on the development of brain edema in hyponatremic rats. Neurosurgery 49(3):697–704, discussion 704–5CrossRefPubMed
Zurück zum Zitat Verbalis JG, Martinez AJ (1991) Neurological and neuropathological sequelae of correction of chronic hyponatremia. Kidney Int 39(6):1274–1282CrossRefPubMed Verbalis JG, Martinez AJ (1991) Neurological and neuropathological sequelae of correction of chronic hyponatremia. Kidney Int 39(6):1274–1282CrossRefPubMed
Zurück zum Zitat Vexler ZS, Ayus JC et al (1994) Hypoxic and ischemic hypoxia exacerbate brain injury associated with metabolic encephalopathy in laboratory animals. J Clin Invest 93(1):256–264CrossRefPubMed Vexler ZS, Ayus JC et al (1994) Hypoxic and ischemic hypoxia exacerbate brain injury associated with metabolic encephalopathy in laboratory animals. J Clin Invest 93(1):256–264CrossRefPubMed
Zurück zum Zitat Yoon B, Shim YS et al (2008) Central pontine and extrapontine myelinolysis after alcohol withdrawal. Alcohol Alcohol 43(6):647–649PubMed Yoon B, Shim YS et al (2008) Central pontine and extrapontine myelinolysis after alcohol withdrawal. Alcohol Alcohol 43(6):647–649PubMed
Zurück zum Zitat Yung M, Keeley S (2009) Randomised controlled trial of intravenous maintenance fluids. J Paediatr Child Health 45(1–2):9–14CrossRefPubMed Yung M, Keeley S (2009) Randomised controlled trial of intravenous maintenance fluids. J Paediatr Child Health 45(1–2):9–14CrossRefPubMed
Metadaten
Titel
100 cc 3% sodium chloride bolus: a novel treatment for hyponatremic encephalopathy
verfasst von
Michael L. Moritz
Juan Carlos Ayus
Publikationsdatum
01.03.2010
Verlag
Springer US
Erschienen in
Metabolic Brain Disease / Ausgabe 1/2010
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-010-9173-2

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