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Neuropsychology Review

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01.09.2011 | Review

Drug Therapy of Post-Stroke Aphasia: A Review of Current Evidence

verfasst von: Marcelo L. Berthier, Friedemann Pulvermüller, Guadalupe Dávila, Natalia García Casares, Antonio Gutiérrez

Erschienen in: Neuropsychology Review | Ausgabe 3/2011

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Abstract

This review considers the role of drug therapy in the treatment of post-stroke aphasia, the evidence for efficacy of different agents, and the theory-based explanations of drug-related benefits for aphasia rehabilitation. Pharmacological interventions modulating stroke-induced disruption of diverse neurotransmitters may improve language and communication deficits in aphasic patients through facilitation of brain plasticity and long-term potentiation. However, benefits are not evident for all compounds and refinement in clinical trial designs is required. Some pharmacological trials have failed because drug treatment was not combined with speech-language therapy, while other trials combining drugs with intensive model-driven therapies also failed probably because of short-trial duration, inadequate sample selection, or lack of drug action. Preliminary data reveals that combining neuroscience-based intensive aphasia techniques (constraint-induced aphasia therapy) and drugs acting on cholinergic and glutamatergic neurotransmitter systems are associated with better outcomes than other strategies and long-term maintenance of benefits. Although further studies are needed, current state of the evidence suggests that drug therapy may play a key role in the treatment of post-stroke aphasia.

Aarsland, D., Larsen, J. P., Reinvang, I., & Aasland, A. M. (1994). Effects of cholinergic blockade on language in healthy young women. Implications for the cholinergic hypothesis in dementia of the Alzheimer type. Brain, 117, 1377–1384.PubMedCrossRef

Albert, M. L., Bachman, D., Morgan, A., & Helm-Estabrooks, N. (1988). Pharmacotherapy of aphasia. Neurology, 38, 877–879.PubMed

Alexander, M. P. (2006). Impairments of procedures for implementing complex language are due to disruption of frontal attention processes. Journal of International Neuropsychological Society, 12, 236–247.

Altieri, M., Di Piero, V., & Lenzi, G. L. (2002). Drugs and recovery: A challenge for a few? Stroke, 33, 1170. letter.PubMedCrossRef

Arciniegas, D. B., Frey, K. L., Anderson, C. A., Brousseau, K. M., & Harris, S. N. (2004). Amantadine for neurobehavioural deficits following delayed post-hypoxic encephalopathy. Brain Injury, 18, 1309–1318.PubMedCrossRef

Ashtary, F., Janghorbani, M., Chitsaz, A., Reisi, M., & Bahrami, A. (2006). A randomized, double blind trial of bromocriptine efficacy in nonfluent aphasia after stroke. Neurology, 66, 914–916.PubMedCrossRef

Auchus, A. P., Brashear, H. R., Salloway, S., Korczyn, A. D., De Deyn, P. P., Gassmann-Mayer, C., et al. (2007). Galantamine treatment of vascular dementia: A randomized trial. Neurology, 69, 448–458.PubMedCrossRef

Baker, J. M., Rorden, C., & Fridriksson, J. (2010). Using transcranial direct-current stimulation to treat stroke patients with aphasia. Stroke, 41, 1129–1236.

Barker-Collo, S., & Feigin, V. (2006). The impact of neuropsychological deficits on functional stroke outcomes. Neuropsychology Review, 16, 53–64.PubMedCrossRef

Barrett, A. M., & Eslinger, P. J. (2007). Amantadine for adynamic speech: Possible benefit for aphasia? American Journal of Physical Medicine and Rehabilitation, 86, 605–612.PubMedCrossRef

Barrett, A. M., Levy, C. E., & Gonzalez Rothi, L. J. (2007). Pharmaceuticals for poststroke and brain injury rehabilitation. Americal Journal of Physical Medicine and Rehabilitation, 86, 603–604.CrossRef

Basso, A. (2003). Aphasia and its therapy. Oxford: Oxford University Press.

Basso, A., & Caporali, A. (2001). Aphasia therapy or the importance of being earnest. Aphasiology, 15, 307–332.CrossRef

Basso, A., & Macis, M. (2011). Therapy efficacy in chronic aphasia. Behavioural Neurology (in press).

Basso, A., Bracchi, M., Capitani, E., Laiacona, M., & Zanobio, M. E. (1987). Age and evolution of language area functions. A study on adult stroke patients. Cortex, 23, 475–483.PubMed

Bersano, A., Burgio, F., Gattinoni, M., Candelisem, L., & PROSIT Study Group. (2009). Aphasia burden to hospitalised acute stroke patients: Need for an early rehabilitation programme. International Journal of Stroke, 4, 443–447.PubMedCrossRef

Berthier, M. L. (1999). Transcortical Aphasias. Hove: Psychology.

Berthier, M. L. (2005). Poststroke aphasia: Epidemiology, pathophysiology and treatment. Drugs & Aging, 22, 163–182.CrossRef

Berthier, M. L., & Pulvermüller, F. (2011). Neuroscience insights improve neurorehabilitation of poststroke aphasia. Nature Reviews. Neurology, 7, 86–97.PubMedCrossRef

Berthier, M. L., Hinojosa, J., Martín, M. C., & Fernandez, I. (2003). Open-label study of donepezil in chronic poststroke aphasia. Neurology, 60, 1218–1219.PubMed

Berthier, M. L., Moreno-Torres, I., & Hinojosa, J. (2004). Beneficial effects of donepezil and modalityspecific language therapy on chronic conduction aphasia. Neurology, 62(Suppl. 5), A462. abstract.

Berthier, M. L., Green, C., Higueras, C., Fernandez, I., Hinojosa, J., & Martín, M. C. (2006). A randomized, placebo-controlled study of donepezil in poststroke aphasia. Neurology, 67, 1687–1689.PubMedCrossRef

Berthier, M. L., Green, C., Lara, J. P., Higueras, C., Barbancho, M. A., Dávila, G., et al. (2009). Memantine and constraint-induced aphasia therapy in chronic poststroke aphasia. Annals of Neurology, 65, 577–585.PubMedCrossRef

Beversdorf, D. Q., Sharma, U. K., Phillips, N. N., Notestine, M. A., Slivka, A. P., Friedman, N. M., et al. (2007). Effect of propranolol on naming in chronic Broca’s aphasia with anomia. Neurocase, 13, 256–259.PubMedCrossRef

Bhogal, S. K., Teasell, R., & Speechley, M. (2003). Intensity of aphasia therapy, impact on recovery. Stroke, 34, 987–993.PubMedCrossRef

Bragoni, M., Altieri, M., Di Piero, V., Padovani, A., Mostardini, C., & Lenzi, G. L. (2000). Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke. Neurological Science, 21, 19–22.CrossRef

Breier, J. I., Maher, L. M., Schmadeke, S., Hasan, K. M., & Papanicolaou, A. C. (2007). Changes in language-specific brain activation after therapy for aphasia using magnetoencephalography: A case study. Neurocase, 13, 169–177.PubMedCrossRef

Breier, J. I., Juranek, J., Maher, L. M., Schmadeke, S., Men, D., & Papanicolaou, A. C. (2009). Behavioral and neurophysiologic response to therapy for chronic aphasia. Archives of Physical Medicine and Rehabilitation, 90, 2026–2033.PubMedCrossRef

Cabeza, R. (2002). Hemispheric asymmetry reduction in older adults: The HAROLD model. Psychology and Aging, 17, 85–100.PubMedCrossRef

Cappa, S. F., Benke, T., Clarke, S., Rossi, B., Stemmer, B., & van Heuten, C. M. (2003). EFNS guidelines on cognitive rehabilitation: Report of an EFNS Task Force. European Journal of Neurology, 10, 11–23.PubMedCrossRef

Carter, A. R., Connor, L. T., & Dromerick, A. W. (2010). Rehabilitation after stroke: Current state of science. Current Neurology and Neuroscience Reports, 10, 158–166.PubMedCrossRef

Chen, Y., Li, Y. S., Wang, Z. Y., Xu, Q., & Shi, G. W. (2010). The efficacy of donepezil for post-stroke aphasia: A pilot case control study. Zhonghua Nei Ke Za Zhi, 49, 115–118.PubMed

Cherney, L. R., & Small, S. L. (2006). Task-dependent changes in brain activation following therapy for nonfluent aphasia: Discussion of two individual cases. Journal of International Neuropsychological Society, 6, 828–842.

Cherney, L. R., Patterson, J. P., Raymer, A., Frymark, T., & Schooling, T. (2008). Evidence-based systematic review: Effects of intensity of treatment and constraint-induced language therapy for individuals with stroke-induced aphasia. Journal of Speech, Language, and Hearing Research, 51, 1282–1299.PubMedCrossRef

Cherney, L. R., Erickson, R. K., & Small, S. L. (2010). Epidural cortical stimulation as adjunctive treatment for non-fluent aphasia: Preliminary findings. Journal of Neurology, Neurosurgery, and Psychiatry, 81, 1014–1021.PubMedCrossRef

Chuah, Y. M. L., & Chee, M. W. L. (2008). Cholinergic augmentation modulates visual task performance in sleep-deprived young adults. Journal of Neuroscience, 28, 11369–11377.PubMedCrossRef

Cicerone, K. D., Langenbahn, D. M., Braden, C., Malec, J. F., Kalmar, K., Fraas, M., et al. (2011). Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Archives of Physical Medicine and Rehabilitation, 92, 519–530.PubMedCrossRef

Code, C. (2001). Multifactorial processes in recovery from aphasia: Developing the foundations for a multileveled framework. Brain and Language, 77, 25–44.PubMedCrossRef

Code, C., Torney, A., Gildea-Howardine, E., & Willmes, K. (2010). Outcome of a 1-month therapy intensive for chronic aphasia: Variable individual responses. Seminars in Speech and Language, 31, 21–33.PubMedCrossRef

Coelho, F., & Birks, J. (2001). Physostigmine for Alzheimer’s disease. Cochrane Database of Systematic Reviews, 2, CD001499.

Cohen, L., Chaaban, B., & Habert, M.-O. (2004). Transient improvement of aphasia with zolpidem. The New England Journal of Medicine, 350, 949–950.PubMedCrossRef

Corbett, F., Jefferies, E., & Lambon Ralph, M. A. (2008). The use of cueing to alleviate recurrent verbal perseverations: Evidence from transcortical sensory aphasia. Aphasiology, 22, 363–382.CrossRef

Cramer, S. C. (2008). Repairing the human brain after stroke. II. Restorative therapies. Annals of Neurology, 63, 549–560.PubMedCrossRef

Cramer, S. C., & Riley, J. D. (2008). Neuroplasticity and brain repair after stroke. Current Opinion in Neurology, 21, 76–82.PubMedCrossRef

Crinion, J. T., & Leff, A. P. (2007). Recovery and treatment of aphasia after stroke: Functional imaging studies. Current Opinion in Neurology, 20, 667–673.PubMedCrossRef

Crosson, B., Moore, A. B., Gopinath, K., White, K. D., Wierenga, C. E., Gaiefsky, M. E., et al. (2005). Role of the right and left hemispheres in recovery of function during treatment of intention in aphasia. Journal of Cognitive Neuroscience, 17, 392–406.PubMedCrossRef

Dale, A. M., Fischl, B., & Sereno, M. I. (1999). Cortical surface-based analysis. I. Segmentation and surface reconstruction. NeuroImage, 9, 179–194.PubMedCrossRef

de Boissezon, X., Peran, P., de Boysson, C., & Démonet, J. F. (2007). Pharmacotherapy of aphasia: Myth or reality? Brain and Language, 102, 114–125.PubMedCrossRef

de Riesthal, M., & Wertz, R. T. (2004). Prognosis for aphasia: Relaitonship between selected biographical and behavioural variables and outcome improvement. Aphasiology, 18, 899–915.CrossRef

Dickey, L., Kagan, A., Lindsay, M. P., Fang, J., Rowland, A., & Black, S. (2010). Incidence and profile of inpatient stroke-induced aphasia in Ontario, Canada. Archives of Physical Medicine and Rehabilitation, 91, 196–202.PubMedCrossRef

Dobkin, B. H. (2004). Strategies for stroke rehabilitation. Lancet Neurology, 3, 528–536.PubMedCrossRef

Elman, R. J., Ogar, J., & Elman, S. H. (2000). Aphasia: Awareness, advocacy, and activism. Aphasiology, 14, 455–459.CrossRef

Endres, M., Engelhardt, B., Koistinaho, J., Lindvall, O., Meairs, S., Mohr, J. P., et al. (2008). Improving outcome after stroke: Overcoming the translational roadblock. Cerebrovascular Diseases, 25, 268–278.PubMedCrossRef

Engelter, S. T., Gostynski, M., Papa, S., Frei, M., Born, C., Ajdacic-Gross, V., et al. (2006). Epidemiology of aphasia attributable to first ischemic stroke: Incidence, severity, fluency, etiology, and thrombolysis. Stroke, 37, 1379–1384.PubMedCrossRef

Eslinger, P. J., & Damasio, A. R. (1981). Age and type of aphasia in patients with stroke. Journal of Neurology, Neurosurgery, and Psychiatry, 44, 377–381.PubMedCrossRef

Ferris, S., Ihl, R., Robert, P., Winblad, B., Gatz, G., Tennigkeit, F., et al. (2009). Treatment effects of memantine on language in moderate to severe Alzheimer’s disease patients. Alzheimer’s & Dementia, 5, 369–374.CrossRef

Fischl, B., Sereno, M. I., & Dale, A. M. (1999). Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. NeuroImage, 9, 195–207.PubMedCrossRef

Fischl, B., Liu, A., & Dale, A. M. (2001). Automated manifold surgery: Constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Transactions on Medical Imaging, 20, 70–80.PubMedCrossRef

FitzGerald, D. B., Crucian, G. P., Mielke, J. B., Shenal, B. V., Burks, D., Womack, K. B., et al. (2008). Effects of donepezil on verbal memory after semantic processing in healthy older adults. Cognitive and Behavioral Neurology, 21, 57–64.PubMedCrossRef

Floel, A., & Cohen, L. G. (2010). Recovery of function in humans: Cortical stimulation and pharmacological treatments after stroke. Neurobiology of Disease, 37, 243–251.PubMedCrossRef

Fridriksson, J., Moser, D., Bonilha, L., Morrow-Odom, K. L., Shaw, H., Fridriksson, A., et al. (2007). Neural correlates of phonological and semantic-based anomia treatment in aphasia. Neuropsychologia, 45, 1812–1822.PubMedCrossRef

Fucetola, R., Connor, L. T., Perry, J., Leo, P., Tucker, F. M., & Corbetta, M. (2005a). Aphasia severity, semantics, and depression predict functional communication in acquired aphasia. Aphasiology, 20, 449–461.CrossRef

Fucetola, R., Tucker, F., Blank, K., & Corbetta, M. (2005b). A process for translating evidence-based aphasia treatment into clinical practice. Aphasiology, 19, 411–422.CrossRef

Galletta, E. E., Rao, P. R., & Barrett, A. M. (2011). Transcranial magnetic stimulation (TMS): Potential progress for language improvement in aphasia. Topics in Stroke Rehabilitation, 18, 87–91.PubMedCrossRef

Goldstein, L. B. (2009). Amphetamine trials and tribulations. Stroke, 40(3 Suppl), S133–S135.PubMedCrossRef

Gonzalez Rothi, L. J., & Barrett, A. M. (2006). The changing view of neurorehabilitation: A new era of optimism. Journal of International Neuropsychological Society, 12, 812–815.

Gotts, S. J., della Rocchetta, A. I., & Cipolotti, L. (2002). Mechanisms underlying perseveration in aphasia: Evidence from a single case study. Neuropsychologia, 40, 1930–1947.PubMedCrossRef

Greenwood, P. M. (2007). Functional plasticity in cognitive aging: Review and hypothesis. Neuropsychology, 21, 657–673.PubMedCrossRef

Grenner, J., Enderby, P., & Whurr, R. (2001). Pharmacological treatment for aphasia following stroke. Cochrane Database of Systematic Reviews, Issue 4. Art. No.: CD000424. doi:10.1002/14651858.CD000424.

Grön, G., Kirstein, M., Thielscher, A., Riepe, M. W., & Spitzer, M. (2005). Cholinergic enhancement of episodic memory in healthy young adults. Psychopharmacology, 182, 170–179.PubMedCrossRef

Güngör, L., Terzi, M., & Onar, M. K. (2011). Does long term use of piracetam improve speech disturbances due to ischemic cerebrovascular diseases? Brain and Language Jan 10. [Epub ahead of print].

Gupta, S. R., & Mlcoch, A. G. (1992). Bromocriptine treatment of nonfluent aphasia. Archives of Physical Medicine and Rehabilitation, 73, 373–376.PubMedCrossRef

Gupta, S. R., Mlcoch, A. G., Scolaro, C., & Moritz, T. (1995). Bromocriptine treatment of nonfluent aphasia. Neurology, 45, 2170–2173.PubMed

Heiss, W. D., & Thiel, A. (2006). A proposed regional hierarchy in recovery of post-stroke aphasia. Brain and Language, 98, 118–123.PubMedCrossRef

Hillis, A. E. (2007). Pharmacological, surgical, and neurovascular interventions to augment acute aphasia recovery. American Journal of Physical Medicine & Rehabilitation, 86, 426–434.CrossRef

Holland, A. L., Greenhouse, J. B., Fromm, D., & Swindell, C. S. (1989). Predictors of language restitution following stroke: A multivariate analysis. Journal of Speech and Hearing Research, 32, 232–238.PubMed

Huber, W. (1999). The role of piracetam in the treatment of acute and chronic aphasia. Pharmacopsychiatry, 32(Suppl 1), 38–43.PubMedCrossRef

Hughes, J. D., Jacobs, D. H., & Heilman, K. M. (2000). Neuropharmacology and linguistic neuroplasticity. Brain and Language, 71, 96–101.PubMedCrossRef

Hutchison, C. W., Nathan, P. J., Mrazek, L., & Stough, C. (2001). Cholinergic modulation of speed of early information processing: The effect of donepezil on inspection time. Psychopharmacology, 155, 440–442.PubMedCrossRef

Jacobs, D. H., Shuren, J., Gold, M., Adair, J. C., Bowers, D., Williamson, D. J. G., et al. (1996). Physostigmine pharmacotherapy for anomia. Neurocase, 2, 83–91.CrossRef

Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002). Improved optimisation for the robust and accurate linear registration and motion correction of brain images. NeuroImage, 17, 825–841.PubMedCrossRef

Jianu, D. C., Muresanu, D. F., Bajenaru, O., Popescu, B. O., Deme, S. M., Moessler, H., et al. (2010). Cerebrolysin adjuvant treatment in Broca’s aphasics following first acute ischemic stroke of the left middle cerebral artery. Journal of Medicine and Life, 3, 297–307.PubMed

Kabasawa, H., Matsubara, M., Kamimoto, K., Hibino, H., Banno, T., & Nagai, H. (1994). Effects of bifemelane hydrochloride on cerebral circulation and metabolism in patients with aphasia. Clinical Therapeutics, 16, 471–482.PubMed

Kasa, P., Papp, H., Kasa, P., & Torok, I. (2000). Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain. Neuroscience, 101, 89–100.PubMedCrossRef

Kelly, H., Brady, M. C., & Enderby, P. (2010). Speech and language therapy for aphasia following stroke. Cochrane Database of Systematic Reviews, 12(5), CD000425.

Kertesz, A. (1979). Aphasia and associated disorders. Taxonomy, localization, and recovery. New York: Grune and Stratton.

Kertesz, A., Morlog, D., Light, M., Blair, M., Davidson, W., Jesso, S., et al. (2008). Galantamine in frontotemporal dementia and primary progressive aphasia. Dementia and Geriatric Cognitive Disorders, 25, 178–185.PubMedCrossRef

Kessler, J., Thiel, A., Karbe, H., & Heiss, W. D. (2000). Piracetam improves activated blood flow and facilitates rehabilitation of poststroke aphasic patients. Stroke, 31, 2112–2116.PubMedCrossRef

Kirmess, M., & Maher, L. M. (2010). Constraint induced language therapy in early aphasia rehabilitation. Aphasiology, 24, 725–736.CrossRef

Kirvell, S. L., Elliott, M. S., Kalaria, R. N., Hortobágyi, T., Ballard, C., & Francis, P. T. (2010). Vesicular glutamate transporter and cognition in stroke. A case-control autopsy study. Neurology, 75, 1803–1809.PubMedCrossRef

Klein, R. B., & Albert, M. L. (2004). Can drug therapies improve language functions of individuals with aphasia? A review of the evidence. Seminars in Speech and Language, 25(2), 193–204.PubMedCrossRef

Knecht, S., Breitenstein, C., Bushuven, S., Wailke, S., Kamping, S., Flöel, A., et al. (2004). Levodopa: Faster and better word learning in normal humans. Annals of Neurology, 56, 20–26.PubMedCrossRef

Kulisevsky, J., García-Sánchez, C., Berthier, M. L., Barbanoj, M., Pascual-Sedano, B., Gironell, A., et al. (2000). Chronic effects of dopaminergic replacement on cognitive function in Parkinson’s disease: A 2-year follow-up study of previously untreated patients. Movement Disorders, 15, 613–626.PubMedCrossRef

Lambon Ralph, M. A., Snell, C., Fillingham, J. K., Conroy, P., & Sage, K. (2010). Predicting the outcome of anomia therapy for people with aphasia post CVA: Both language and cognitive status are key predictors. Neuropsychological Rehabilitation, 20, 289–305.CrossRef

Laska, A. C., Hellblom, A., Murray, V., Kahan, T., & Von Arbin, M. (2001). Aphasia in acute stroke and relation to outcome. Journal of Internal Medicine, 249, 413–422.PubMedCrossRef

Law, J., Rush, R., Pringle, A.-M., Irving, A.-M., Huby, G., Smith, M., et al. (2009). The incidence of cases of aphasia following first stroke referred to speech and language therapy services in Scotland. Aphasiology, 23, 1266–1275.CrossRef

Lazar, R. M., & Antoniello, D. (2008). Variability in recovery from aphasia. Current Neurology and Neuroscience Reports, 8, 497–502.PubMedCrossRef

Lazar, R. M., Speizer, A. E., Festa, J. R., Krakauer, J. W., & Marshall, R. S. (2008). Variability in language recovery after first-time stroke. Journal of Neurology, Neurosurgery, and Psychiatry, 79, 530–534.PubMedCrossRef

Lazar, R. M., Minzer, B., Antoniello, D., Festa, J. R., Krakauer, J. W., & Marshall, R. S. (2010). Improvement in aphasia scores after stroke is well predicted by initial severity. Stroke, 41, 1485–1488.PubMedCrossRef

Lee, A. W., & Hillis, A. E. (2008). The pharmacological treatment of aphasia. In B. Stemmer & H. A. Whitaker (Eds.), Handbook of the neuroscience of language (pp. 407–415). London: Academic.

Leemann, B., Laganaro, M., Chetelat-Mabillard, D., & Schnider, A. (2010). Crossover trial of subacute computerized aphasia therapy for anomia with the addition of either levodopa or placebo. Neurorehabilitation and Neural Repair. doi:10.1177/1545968310376938.

Li, S. C., Lindenberger, U., & Sikström, S. (2001). Aging cognition: From neuromodulation to representation. Trends in Cognitive Sciences, 5, 479–486.PubMedCrossRef

Liepert, J. (2008). Pharmacotherapy in restorative neurology. Current Opinion in Neurology, 21, 639–643.PubMedCrossRef

Linebarger, M., McCall, D., Virata, T., & Berndt, R. S. (2007). Widening the temporal window: Processing support in the treatment of aphasic language production. Brain and Language, 100, 53–68.PubMedCrossRef

Lipton, S. A. (2007). Pathologically-activated therapeutics for neuroprotection: Mechanism of NMDA receptor block by memantine and S-nitrosylation. Current Drug Targets, 8, 621–632.PubMedCrossRef

Luria, A., Naydyn, V. L., Tsvetkova, L. S., & Vinarskaya, E. N. (1969). Restoration of higher cortical function following local brain damage. In P. J. Vinken & G. W. Bruyn (Eds.), Handbook of clinical neurology (pp. 368–433). Amsterdam: North-Holland Publishing Company.

Mackowiak-Cordoliani, M. A., Bombois, S., Memin, A., Hénon, H., & Pasquier, F. (2005). Poststroke dementia in the elderly. Drugs & Aging, 22, 483–493.CrossRef

Malykh, A. G., & Sadaie, M. R. (2010). Piracetam and piracetam-like drugs. From basic science to novel clinical applications to CNS disorders. Drugs, 70, 287–312.PubMedCrossRef

Martin, H. G., & Wang, Y. T. (2010). Blocking the deadly effects of the NMDA receptor in stroke. Cell, 140, 174–176.PubMedCrossRef

Martinsson, L., & Eksborg, S. (2004). Drugs for stroke recovery: The example of amphetamines. Drugs & Aging, 21, 67–79.CrossRef

McClung, J. S., Rothi, L. J., & Nadeau, S. E. (2010). Ambient experience in restitutive treatment of aphasia. Frontiers in Human Neuroscience, 4, 183.PubMedCrossRef

McKeage, K. (2009). Memantine: A review of its use in moderate to severe Alzheimer’s disease. CNS Drugs, 23, 881–897.PubMedCrossRef

McNamara, P., & Albert, M. L. (2004). Neuropharmacology of verbal perseveration. Seminars in Speech and Language, 25, 309–321.PubMedCrossRef

McNeil, M. R., Doyle, P. J., Spencer, K. A., Goda, A. J., Flores, D., & Small, S. L. (1997). A double-blind, placebo-controlled study of pharmacological and behavioural treatment of lexical-semantic deficits in aphasia. Aphasiology, 11, 385–400.CrossRef

Meinzer, M., Djundja, D., Barthel, G., Elbert, T., & Rockstroh, B. (2005). Long-term stability of improved language functions in chronic aphasia after constraint-induced aphasia therapy. Stroke, 36, 1462–1466.PubMedCrossRef

Meinzer, M., Streiftau, S., & Rockstroh, B. (2007). Intensive language training in the rehabilitation of chronic aphasia: Efficient training by laypersons. Journal of International Neuropsychological Society, 13, 846–853.CrossRef

Meinzer, M., Flaisch, T., Breitenstein, C., Wienbruch, C., Elbert, T., & Rockstroh, B. (2008). Functional re-recruitment of dysfunctional brain areas predicts language recovery in chronic aphasia. NeuroImage, 39, 2038–2046.PubMedCrossRef

Meinzer, M., Harnish, S., Conway, T., & Crosson, B. (2011). Recent developments in functional and structural imaging of aphasia recovery after stroke. Aphasiology, 25, 271–290.PubMedCrossRef

Menke, R., Meinzer, M., Kugel, H., Deppe, M., Baumgärtner, A., Schiffbauer, H., et al. (2009). Imaging short- and long-term training success in chronic aphasia. BMC Neuroscience, 10, 118.PubMedCrossRef

Mesulam, M., Siddique, T., & Cohen, B. (2003). Cholinergic denervation in a pure multi-infarct state: Observations on CADASIL. Neurology, 60, 1183–1185.PubMed

Micu, I., Jiang, Q., Coderre, E., Ridsdale, A., Zhang, L., Woulfe, J., et al. (2006). NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature, 439, 988–992.PubMed

Naeser, M. A., Martin, P. I., Lundgren, K., Klein, R., Kaplan, J., Treglia, E., et al. (2010). Improved language in a chronic nonfluent aphasia patient after treatment with CPAP and TMS. Cognitive and Behavioral Neurology, 23, 29–38.PubMedCrossRef

Nakahata, K., Kinoshita, H., Hama-Tomioka, K., Ishida, Y., Matsuda, N., Hatakeyama, N., et al. (2008). Cholinesterase inhibitor donepezil dilates cerebral parenchymal arterioles via the activation of neuronal nitric oxide synthase. Anesthesiology, 109, 124–129.PubMedCrossRef

Nicholas, M., Connor, L. T., Obler, L. K., & Albert, M. L. (1998). Aging, language, and language disorders. In M. T. Sarno (Ed.), Acquired Aphasia (3rd ed., pp. 413–449). San Diego: Academic.CrossRef

Olesen, J., Baker, M. G., Freund, T., di Luca, M., Mendlewicz, J., Ragan, I., et al. (2006). Consensus documents on European brain research. Journal of Neurology, Neurosurgery, and Psychiatry, 77(Suppl I), i1–i49.PubMed

Orgogozo, J. M., Rigaud, A. S., Stöffler, A., Möbius, H. J., & Forette, F. (2002). Efficacy and safety of memantine in patients with mild to moderate vascular dementia: A randomized, placebo-controlled trial (MMM 300). Stroke, 33, 1834–1839.PubMedCrossRef

Ozeren, A., Sarica, Y., Mavi, H., & Demirkiran, M. (1995). Bromocriptine is ineffective in the treatment of chronic nonfluent aphasia. Acta Neurologica Belgica, 95, 235–238.PubMed

Parsons, C. G., Stöffler, A., & Danysz, W. (2007). Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system—too little activation is bad, too much is even worse. Neuropharmacology, 53, 699–723.PubMedCrossRef

Parton, A., Coulthard, E., & Husain, M. (2005). Neuropharmacological modulation of cognitive deficits after brain damage. Current Opinion in Neurology, 18, 675–680.PubMedCrossRef

Pashek, G. V., & Bachman, D. L. (2003). Cognitive, linguistic, and motor speech of donepezil hydrochloride in a patient with stroke-related aphasia and apraxia of speech. Brain and Language, 87, 179–180.CrossRef

Pedersen, P. M., Jørgensen, H. S., Nakayama, H., Raaschou, H. O., & Olsen, T. S. (1995). Aphasia in acute stroke: Incidence, determinants, and recovery. Annals of Neurology, 38, 659–666.PubMedCrossRef

Pedersen, P. M., Vinter, K., & Olsen, T. S. (2004). Aphasia after stroke: Type, severity and prognosis. The Copenhagen aphasia study. Cerebrovascular Diseases, 17, 35–43.PubMedCrossRef

Peisker, T., Bartoš, A., Skoda, O., Ibrahim, I., & Kalvach, P. (2010). Impact of aging on cerebral vasoregulation and parenchymal integrity. Journal of Neurological Sciences, 299, 112–115.CrossRef

Price, J. L., McKeel, D. W. Jr., Buckles, V. D., Roe, C. M., Xiong, C., Grundman, M., et al. (2009). Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiology of Aging, 30, 1026–1036.PubMedCrossRef

Price, C. J., Seghier, M. L., & Leff, A. P. (2010). Predicting language outcome and recovery after stroke: The PLORAS system. Nature Reviews. Neurology, 6, 202–210.PubMedCrossRef

Pulvermüller, F., & Berthier, M. L. (2008). Aphasia therapy on a neuroscience basis. Aphasiology, 22, 563–599.PubMedCrossRef

Pulvermüller, F., Neininger, B., Elbert, T., Mohr, B., Rockstroh, B., Koebbel, P., et al. (2001). Constraint-induced therapy of chronic aphasia following stroke. Stroke, 32, 1621–1626.PubMedCrossRef

Pulvermüller, F., Hauk, O., Zohsel, K., Neininger, B., & Mohr, B. (2005). Therapy-related reorganization of language in both hemispheres of patients with chronic aphasia. NeuroImage, 28, 481–489.PubMedCrossRef

Raymer, A. M. (2003). Treatment of adynamia in aphasia. Front Bioscience, 8, s845–s851.CrossRef

Raymer, A. M., Bandy, D., & Adair, J. C. (2001). Effects of bromocriptine in a patient with crossed nonfluent aphasia: A case report. Archives of Physical Medicine and Rehabilitation, 82, 139–144.PubMedCrossRef

Román, G. C., & Kalaria, R. N. (2006). Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia. Neurobiology of Aging, 27, 1769–1785.PubMedCrossRef

Román, G. C., Wilkinson, D. G., Doody, R. S., Black, S. E., Salloway, S. P., & Schindler, R. J. (2005). Donepezil in vascular dementia: Combined analysis of two large-scale clinical trials. Dementia and Geriatric Cognitive Disorders, 20, 338–344.PubMedCrossRef

Sabe, L., Leiguarda, R., & Starkstein, S. E. (1992). An open-label trial of bromocriptine in nonfluent aphasia. Neurology, 42, 1637–1638.PubMed

Sabe, L., Salvarezza, F., García Cuerva, A., Leiguarda, R., & Starkstein, S. (1995). A randomized, double-blind, placebo-controlled study of bromocriptine in nonfluent aphasia. Neurology, 45, 2272–2274.PubMed

Sarter, M., Hasselmo, M. E., Bruno, J. P., & Givens, B. (2005). Unraveling the attentional functions of cortical cholinergic inputs: Interactions between signal-driven and cognitive modulation of signal detection. Brain Research Reviews, 48, 98–111.PubMedCrossRef

Saur, D., Lange, R., Baumgaertner, A., Schraknepper, V., Willmes, K., Rijntjes, M., et al. (2006). Dynamics of language reorganization after stroke. Brain, 129, 1371–1384.PubMedCrossRef

Sawyer, E., Mauro, L. S., & Ohlinger, M. J. (2008). Amantadine enhancement of arousal and cognition after traumatic brain injury. The Annals of Pharmacotherapy, 42, 247–252.PubMedCrossRef

Schlaug, G., Marchina, S., & Norton, A. (2009). Evidence for plasticity in white-matter tracts of patients with chronic Broca’s aphasia undergoing intense intonation-based speech therapy. Annals of New York Academy of Sciences, 1169, 385–394.CrossRef

Selden, N. R., Gitelman, D. R., Salamon-Murayama, N., et al. (1998). Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain. Brain, 121, 2249–2257.PubMedCrossRef

Seniów, J., Litwin, M., Litwin, T., Leśniak, M., & Członkowska, A. (2009). New approach to the rehabilitation of post-stroke focal cognitive syndrome: Effect of levodopa combined with speech and language therapy on functional recovery from aphasia. Journal of Neurological Sciences, 28, 214–218.CrossRef

Sharp, S. I., Francis, P. T., Elliott, M. S., Kalaria, R. N., Bajic, N., Hortobagyi, T., et al. (2009). Choline acetyltransferase activity in vascular dementia and stroke. Dementia and Geriatric Cognitive Disorders, 28, 233–238.PubMedCrossRef

Shisler, R. J., Baylis, G. C., & Frank, E. M. (2000). Pharmacological approaches to the treatment and prevention of aphasia. Aphasiology, 14, 1163–1186.CrossRef

Šimić, G., Mrzljak, L., Fučić, A., et al. (1999). Nucleus subputaminalis (Ayala): The still disregarded magnocellular component of the basal forebrain may be human specific and connected with the cortical speech area. Neuroscience, 89, 73–89.PubMedCrossRef

Simmons-Mackie, N., Code, C., Armstrong, E., Stiegler, L., & Elman, R. J. (2002). What is aphasia? Results of an international survey. Aphasiology, 16, 837–848.CrossRef

Small, S. L., & Llano, D. A. (2009). Biological approaches to aphasia treatment. Current Neurology and Neuroscience Reports, 9, 443–450.PubMedCrossRef

Smith, S. M. (2002). Fast robust automated brain extraction. Human Brain Mapping, 17, 143–155.PubMedCrossRef

Staekenborg, S. S., van der Flier, W. M., van Straaten, E. C., Lane, R., Barkhof, F., & Scheltens, P. (2008). Neurological signs in relation to type of cerebrovascular disease in vascular dementia. Stroke, 39, 317–322.PubMedCrossRef

Starkstein, S. E., & Robinson, R. G. (1988). Depression and aphasia. Aphasiology, 2, 1–20.CrossRef

Stys, P. K., & Lipton, S. A. (2007). White matter NMDA receptors: An unexpected new therapeutic target? Trends in Pharmacological Sciences, 28, 561–566.PubMedCrossRef

Swartz, R. H., Sahlas, D. J., & Black, S. E. (2003). Strategic involvement of cholinergic pathways and executive dysfunction: Does location of white matter signal hyperintensities matter? Journal of Stroke and Cerebrovascular Diseases, 12, 29–36.PubMedCrossRef

Tanaka, Y., & Bachman, D. L. (2007). Pharmacotherapy of aphasia. In L. S. Connor & L. K. Obler (Eds.), Neurobehavior of language and cognition studies of normal aging and brain damage (pp. 159–162). Berlin: SpringerLink.

Tanaka, Y., Miyazaki, M., & Albert, M. L. (1997). Effect of increased cholinergic activity on naming in aphasia. Lancet, 350, 116–117.PubMedCrossRef

Triggle, D. J. (1996). Dictionary of pharmacological agents. Boca Raton: Chapman & Hall/CRC.

Tsikunov, S. G., & Belokoskova, S. G. (2007). Psychophysiological analysis of the influence of vasopressin on speech in patients with poststroke aphasias. Spanish Journal of Psychology, 10, 178–188.PubMed

Tsouli, S., Kyritsis, A. P., Tsagalis, G., Virvidaki, E., & Vemmos, K. N. (2009). Significance of aphasia after first-ever acute stroke: Impact on early and late outcomes. Neuroepidemiology, 33, 96–102.PubMedCrossRef

Tsz-Ming, C., & Kaufer, D. J. (2001). Effects of donepezil on aphasia, agnosia, and apraxia in patients with cerebrovascular lesions. The Journal of Neuropsychiatry and Clinical Neurosciences, 13, 140. abstract.

Uchida, S., Suzuki, A., Kagitani, F., & Hotta, H. (2000). Effects of age on cholinergic vasodilation of cortical cerebral blood vessels in rats. Neuroscience Letters, 294, 109–112.PubMedCrossRef

van Dyck, C., Schmitt, F. A., Olin, J. T., & for the Memantine MEM-MD-02 Study Group. (2006). A responder analysis of memantine treatment in patients with Alzheimer disease maintained on donepezil. The American Journal of Geriatric Psychiatry, 14, 428–437.PubMedCrossRef

van Wageningen, H., Jørgensen, H. A., Specht, K., Eichele, T., & Hugdahl, K. (2009). The effects of the glutamate antagonist memantine on brain activation to an auditory perception task. Human Brain Mapping, 30, 3616–3624.PubMedCrossRef

Walker-Batson, D., Unwin, H., Curtis, S., Allen, E., Wood, M., Smith, P., et al. (1992). Use of amphetamine in the treatment of aphasia. Restorative Neurology and Neuroscience, 4, 47–50.PubMed

Walker-Batson, D., Curtis, S., Natarajan, R., Ford, J., Dronkers, N., Salmeron, E., et al. (2001). Double-blind, placebo-controlled study of the use of amphetamine in the treatment of aphasia. Stroke, 32, 2093–2098.PubMedCrossRef

Whiting, E., Chenery, H. J., Chalk, J., & Copland, D. A. (2008). Dexamphetamine boosts naming treatment effects in chronic aphasia. Journal of International Neuropsychological Society, 13, 972–979.

Wierenga, C. E., Benjamin, M., Gopinath, K., Perlstein, W. M., Leonard, C. M., Rothi, L. J., et al. (2008). Age-related changes in word retrieval: Role of bilateral frontal and subcortical networks. Neurobiology of Aging, 29, 436–451.PubMedCrossRef

Wilcock, G., Möbius, H. J., Stöffler, A., & MMM 500 group. (2002). A double-blind, placebo-controlled multicentre study of memantine in mild to moderate vascular dementia (MMM500). International Clinical Psychopharmacology, 17, 297–305.PubMedCrossRef

Wilkinson, D., & Andersen, H. F. (2007). Analysis of the effect of memantine in reducing the worsening of clinical symptoms in patients with moderate to severe Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 24, 138–145.PubMedCrossRef

Wilkinson, D., Róman, G., Salloway, S., Hecker, J., Boundy, K., Kumar, D., et al. (2010). The long-term efficacy and tolerability of donepezil in patients with vascular dementia. International Journal of Geriatric Psychiatry, 25, 305–313.PubMedCrossRef

Winblad, B. (2005). Piracetam: A review of pharmacological properties and clinical uses. CNS Drug Reviews, 11, 169–182.PubMedCrossRef

Worsley, K. J. (2001). Statistical analysis of activation images. In P. Jezzard, P. M. Matthews, S. M. Smith (Eds.), Functional MRI: An introduction to methods. Ch14, OUP.

Yesavage, J. A., Mumenthaler, M. S., Taylor, J. L., Friedman, L., O’Hara, R., Sheikh, J., et al. (2002). Donepezil and flight simulator performance: Effects on retention of complex skills. Neurology, 59, 123–125.PubMed

Ziganshina, L. E., Abakumova, T., & Kuchaeva, A. (2010). Cerebrolysin for acute ischaemic stroke. Cochrane Database of Systematic Reviews, 14(4), CD007026.

Titel: Drug Therapy of Post-Stroke Aphasia: A Review of Current Evidence
verfasst von: Marcelo L. Berthier
Friedemann Pulvermüller
Guadalupe Dávila
Natalia García Casares
Antonio Gutiérrez
Publikationsdatum: 01.09.2011
Verlag: Springer US
Erschienen in: Neuropsychology Review / Ausgabe 3/2011
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-011-9177-7

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